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Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease.

Abstract

BACKGROUND

Vitamin A is essential for the preservation and integrity of the lung epithelium and exerts anti-inflammatory effects.

OBJECTIVE

Evaluating vitamin A in the serum and sputum and testing its correlation with inflammatory markers in individuals with or without COPD. Methods. We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7).

RESULTS

COPD exhibited lower serum vitamin A (1.8 (1.2-2.1) versus 2.1 (1.8-2.4) μmol/L, P < 0.001) and lower vitamin A intake (636.9 (339.6-1349.6) versus 918.0 (592.1-1654.6) RAE, P = 0.05) when compared with controls. Sputum concentration of vitamin A was not different between groups. Sputum vitamin A and neutrophils were negatively correlated (R (2) = -0.26; P = 0.03). Smoking (0.197, P = 0.042) exhibited positive association with serum vitamin A. COPD was associated with lower serum concentrations of vitamin A without relationship with the systemic inflammation.

CONCLUSIONS

Serum concentration of vitamin A is negatively associated with the presence of COPD and positively associated with smoking status. Sputum retinol is quantifiable and is negatively influenced by neutrophils. Although COPD patients exhibited increased inflammation it was not associated with serum retinol.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.

    ,

    Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.

    ,

    Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.

    ,

    Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.

    ,

    Department of Pathology, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.

    ,

    Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.

    Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.

    Source

    Mediators of inflammation 2015: 2015 pg 862086

    MeSH

    Adult
    Aged
    Biomarkers
    Cross-Sectional Studies
    Female
    Humans
    Inflammation
    Male
    Middle Aged
    Neutrophils
    Pulmonary Disease, Chronic Obstructive
    Sputum
    Vitamin A

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26339144

    Citation

    Caram, L M O., et al. "Serum Vitamin a and Inflammatory Markers in Individuals With and Without Chronic Obstructive Pulmonary Disease." Mediators of Inflammation, vol. 2015, 2015, p. 862086.
    Caram LM, Amaral RA, Ferrari R, et al. Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease. Mediators Inflamm. 2015;2015:862086.
    Caram, L. M., Amaral, R. A., Ferrari, R., Tanni, S. E., Correa, C. R., Paiva, S. A., & Godoy, I. (2015). Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease. Mediators of Inflammation, 2015, p. 862086. doi:10.1155/2015/862086.
    Caram LM, et al. Serum Vitamin a and Inflammatory Markers in Individuals With and Without Chronic Obstructive Pulmonary Disease. Mediators Inflamm. 2015;2015:862086. PubMed PMID: 26339144.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease. AU - Caram,L M O, AU - Amaral,R A F, AU - Ferrari,R, AU - Tanni,S E, AU - Correa,C R, AU - Paiva,S A R, AU - Godoy,I, Y1 - 2015/08/03/ PY - 2014/08/14/received PY - 2014/10/15/revised PY - 2014/10/16/accepted PY - 2015/9/5/entrez PY - 2015/9/5/pubmed PY - 2016/5/3/medline SP - 862086 EP - 862086 JF - Mediators of inflammation JO - Mediators Inflamm. VL - 2015 N2 - BACKGROUND: Vitamin A is essential for the preservation and integrity of the lung epithelium and exerts anti-inflammatory effects. OBJECTIVE: Evaluating vitamin A in the serum and sputum and testing its correlation with inflammatory markers in individuals with or without COPD. Methods. We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7). RESULTS: COPD exhibited lower serum vitamin A (1.8 (1.2-2.1) versus 2.1 (1.8-2.4) μmol/L, P < 0.001) and lower vitamin A intake (636.9 (339.6-1349.6) versus 918.0 (592.1-1654.6) RAE, P = 0.05) when compared with controls. Sputum concentration of vitamin A was not different between groups. Sputum vitamin A and neutrophils were negatively correlated (R (2) = -0.26; P = 0.03). Smoking (0.197, P = 0.042) exhibited positive association with serum vitamin A. COPD was associated with lower serum concentrations of vitamin A without relationship with the systemic inflammation. CONCLUSIONS: Serum concentration of vitamin A is negatively associated with the presence of COPD and positively associated with smoking status. Sputum retinol is quantifiable and is negatively influenced by neutrophils. Although COPD patients exhibited increased inflammation it was not associated with serum retinol. SN - 1466-1861 UR - https://www.unboundmedicine.com/medline/citation/26339144/full_citation L2 - https://dx.doi.org/10.1155/2015/862086 DB - PRIME DP - Unbound Medicine ER -