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Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease.
Mediators Inflamm 2015; 2015:862086MI

Abstract

BACKGROUND

Vitamin A is essential for the preservation and integrity of the lung epithelium and exerts anti-inflammatory effects.

OBJECTIVE

Evaluating vitamin A in the serum and sputum and testing its correlation with inflammatory markers in individuals with or without COPD. Methods. We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7).

RESULTS

COPD exhibited lower serum vitamin A (1.8 (1.2-2.1) versus 2.1 (1.8-2.4) μmol/L, P < 0.001) and lower vitamin A intake (636.9 (339.6-1349.6) versus 918.0 (592.1-1654.6) RAE, P = 0.05) when compared with controls. Sputum concentration of vitamin A was not different between groups. Sputum vitamin A and neutrophils were negatively correlated (R (2) = -0.26; P = 0.03). Smoking (0.197, P = 0.042) exhibited positive association with serum vitamin A. COPD was associated with lower serum concentrations of vitamin A without relationship with the systemic inflammation.

CONCLUSIONS

Serum concentration of vitamin A is negatively associated with the presence of COPD and positively associated with smoking status. Sputum retinol is quantifiable and is negatively influenced by neutrophils. Although COPD patients exhibited increased inflammation it was not associated with serum retinol.

Authors+Show Affiliations

Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.Department of Pathology, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26339144

Citation

Caram, L M O., et al. "Serum Vitamin a and Inflammatory Markers in Individuals With and Without Chronic Obstructive Pulmonary Disease." Mediators of Inflammation, vol. 2015, 2015, p. 862086.
Caram LM, Amaral RA, Ferrari R, et al. Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease. Mediators Inflamm. 2015;2015:862086.
Caram, L. M., Amaral, R. A., Ferrari, R., Tanni, S. E., Correa, C. R., Paiva, S. A., & Godoy, I. (2015). Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease. Mediators of Inflammation, 2015, p. 862086. doi:10.1155/2015/862086.
Caram LM, et al. Serum Vitamin a and Inflammatory Markers in Individuals With and Without Chronic Obstructive Pulmonary Disease. Mediators Inflamm. 2015;2015:862086. PubMed PMID: 26339144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease. AU - Caram,L M O, AU - Amaral,R A F, AU - Ferrari,R, AU - Tanni,S E, AU - Correa,C R, AU - Paiva,S A R, AU - Godoy,I, Y1 - 2015/08/03/ PY - 2014/08/14/received PY - 2014/10/15/revised PY - 2014/10/16/accepted PY - 2015/9/5/entrez PY - 2015/9/5/pubmed PY - 2016/5/3/medline SP - 862086 EP - 862086 JF - Mediators of inflammation JO - Mediators Inflamm. VL - 2015 N2 - BACKGROUND: Vitamin A is essential for the preservation and integrity of the lung epithelium and exerts anti-inflammatory effects. OBJECTIVE: Evaluating vitamin A in the serum and sputum and testing its correlation with inflammatory markers in individuals with or without COPD. Methods. We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7). RESULTS: COPD exhibited lower serum vitamin A (1.8 (1.2-2.1) versus 2.1 (1.8-2.4) μmol/L, P < 0.001) and lower vitamin A intake (636.9 (339.6-1349.6) versus 918.0 (592.1-1654.6) RAE, P = 0.05) when compared with controls. Sputum concentration of vitamin A was not different between groups. Sputum vitamin A and neutrophils were negatively correlated (R (2) = -0.26; P = 0.03). Smoking (0.197, P = 0.042) exhibited positive association with serum vitamin A. COPD was associated with lower serum concentrations of vitamin A without relationship with the systemic inflammation. CONCLUSIONS: Serum concentration of vitamin A is negatively associated with the presence of COPD and positively associated with smoking status. Sputum retinol is quantifiable and is negatively influenced by neutrophils. Although COPD patients exhibited increased inflammation it was not associated with serum retinol. SN - 1466-1861 UR - https://www.unboundmedicine.com/medline/citation/26339144/full_citation L2 - https://dx.doi.org/10.1155/2015/862086 DB - PRIME DP - Unbound Medicine ER -