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Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose-response meta-analysis.

Abstract

BACKGROUND

Mounting experimental evidence supports a protective effect of high 25-hydroxyvitamin D (25[OH]D), a good indicator of vitamin D status, on risk of various cancers including lung cancer. However, prospective observational studies examining the 25(OH)D-lung cancer association reported inconsistent findings. A dose-response meta-analysis was carried out to elucidate the subject.

METHODS

Potentially eligible studies were identified by searching PubMed and EMBASE databases, and by carefully reviewing the bibliographies of retrieved publications. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random-effects model.

RESULTS

Thirteen reports from ten prospective studies were included, totaling 2,227 lung cancer events. Results of the meta-analysis showed a significant 5% (RR 0.95, 95% CI 0.91-0.99) reduction in the risk of lung cancer for each 10 nmol/L increment in 25(OH)D concentrations. This inverse association was not significantly modified by area, study duration, sex, methods for 25(OH)D measurement, baseline 25(OH)D levels, or quality score of included studies. There was evidence of a nonlinear relationship between 25(OH)D and risk of lung cancer (p-nonlinearity = 0.02), with the greatest reductions in risk observed at 25(OH)D of nearly 53 nmol/L, and remained protective until approximately 90 nmol/L. Further increases showed no significant association with cancer risk, but scanty data were included in the analyses of high-level 25(OH)D. There was no evidence of publication bias.

CONCLUSION

This dose-response meta-analysis of prospective studies suggests that 25(OH)D may be associated with reduced risk of lung cancer, in particular among subjects with vitamin D deficiencies.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou, 215123, China.

    ,

    Department of Labor Hygiene and Environmental Health, School of Public Health, Soochow University, Suzhou, China.

    ,

    Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou, 215123, China.

    ,

    Special Procurement Ward, The First Affiliated Hospital of Soochow University, Suzhou, China.

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    DSM Nutritional Products Ltd., Human Nutrition and Health, Kaiseraugst, Switzerland.

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    DSM Nutritional Products Ltd., Human Nutrition and Health, Kaiseraugst, Switzerland.

    ,

    Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou, 215123, China. qinliqiang@suda.edu.cn.

    DSM Nutritional Products Ltd., Human Nutrition and Health, No. 9 Dongdaqiao Road, Beijing, 100020, China. Wei-Guo.Zhang@dsm.com.

    Source

    Cancer causes & control : CCC 26:12 2015 Dec pg 1719-28

    MeSH

    Humans
    Lung Neoplasms
    Risk Factors
    Risk Reduction Behavior
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    26358829

    Citation

    Chen, Guo-Chong, et al. "Circulating 25-hydroxyvitamin D and Risk of Lung Cancer: a Dose-response Meta-analysis." Cancer Causes & Control : CCC, vol. 26, no. 12, 2015, pp. 1719-28.
    Chen GC, Zhang ZL, Wan Z, et al. Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose-response meta-analysis. Cancer Causes Control. 2015;26(12):1719-28.
    Chen, G. C., Zhang, Z. L., Wan, Z., Wang, L., Weber, P., Eggersdorfer, M., ... Zhang, W. (2015). Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose-response meta-analysis. Cancer Causes & Control : CCC, 26(12), pp. 1719-28. doi:10.1007/s10552-015-0665-6.
    Chen GC, et al. Circulating 25-hydroxyvitamin D and Risk of Lung Cancer: a Dose-response Meta-analysis. Cancer Causes Control. 2015;26(12):1719-28. PubMed PMID: 26358829.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose-response meta-analysis. AU - Chen,Guo-Chong, AU - Zhang,Zeng-Li, AU - Wan,Zhongxiao, AU - Wang,Ling, AU - Weber,Peter, AU - Eggersdorfer,Manfred, AU - Qin,Li-Qiang, AU - Zhang,Weiguo, Y1 - 2015/09/10/ PY - 2015/06/15/received PY - 2015/09/03/accepted PY - 2015/9/12/entrez PY - 2015/9/12/pubmed PY - 2016/6/9/medline KW - 25-Hydroxyvitamin D KW - Lung cancer KW - Meta-analysis KW - Prospective studies SP - 1719 EP - 28 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 26 IS - 12 N2 - BACKGROUND: Mounting experimental evidence supports a protective effect of high 25-hydroxyvitamin D (25[OH]D), a good indicator of vitamin D status, on risk of various cancers including lung cancer. However, prospective observational studies examining the 25(OH)D-lung cancer association reported inconsistent findings. A dose-response meta-analysis was carried out to elucidate the subject. METHODS: Potentially eligible studies were identified by searching PubMed and EMBASE databases, and by carefully reviewing the bibliographies of retrieved publications. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random-effects model. RESULTS: Thirteen reports from ten prospective studies were included, totaling 2,227 lung cancer events. Results of the meta-analysis showed a significant 5% (RR 0.95, 95% CI 0.91-0.99) reduction in the risk of lung cancer for each 10 nmol/L increment in 25(OH)D concentrations. This inverse association was not significantly modified by area, study duration, sex, methods for 25(OH)D measurement, baseline 25(OH)D levels, or quality score of included studies. There was evidence of a nonlinear relationship between 25(OH)D and risk of lung cancer (p-nonlinearity = 0.02), with the greatest reductions in risk observed at 25(OH)D of nearly 53 nmol/L, and remained protective until approximately 90 nmol/L. Further increases showed no significant association with cancer risk, but scanty data were included in the analyses of high-level 25(OH)D. There was no evidence of publication bias. CONCLUSION: This dose-response meta-analysis of prospective studies suggests that 25(OH)D may be associated with reduced risk of lung cancer, in particular among subjects with vitamin D deficiencies. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/26358829/full_citation L2 - https://doi.org/10.1007/s10552-015-0665-6 DB - PRIME DP - Unbound Medicine ER -