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Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management.
Diabetes Metab Syndr Obes 2015; 8:415-26DM

Abstract

Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesis of several metabolic and degenerative disorders. Accumulating evidence underlies the beneficial effect of the dietary restriction of AGEs not only in animal studies but also in patients with diabetic complications and metabolic diseases. This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification.

Authors+Show Affiliations

Endocrine Unit, Medical School University of Athens, Athens, Greece.Endocrine Unit, Medical School University of Athens, Athens, Greece.Endocrine Unit, Medical School University of Athens, Athens, Greece.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26366100

Citation

Palimeri, Sotiria, et al. "Current Perspectives On the Health Risks Associated With the Consumption of Advanced Glycation End Products: Recommendations for Dietary Management." Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, vol. 8, 2015, pp. 415-26.
Palimeri S, Palioura E, Diamanti-Kandarakis E. Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management. Diabetes Metab Syndr Obes. 2015;8:415-26.
Palimeri, S., Palioura, E., & Diamanti-Kandarakis, E. (2015). Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 8, pp. 415-26. doi:10.2147/DMSO.S63089.
Palimeri S, Palioura E, Diamanti-Kandarakis E. Current Perspectives On the Health Risks Associated With the Consumption of Advanced Glycation End Products: Recommendations for Dietary Management. Diabetes Metab Syndr Obes. 2015;8:415-26. PubMed PMID: 26366100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management. AU - Palimeri,Sotiria, AU - Palioura,Eleni, AU - Diamanti-Kandarakis,Evanthia, Y1 - 2015/09/01/ PY - 2015/9/15/entrez PY - 2015/9/15/pubmed PY - 2015/9/15/medline KW - AGEs KW - MSR-1 KW - PCOS KW - RAGE KW - dietary glycotoxins KW - dietary restriction SP - 415 EP - 26 JF - Diabetes, metabolic syndrome and obesity : targets and therapy JO - Diabetes Metab Syndr Obes VL - 8 N2 - Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesis of several metabolic and degenerative disorders. Accumulating evidence underlies the beneficial effect of the dietary restriction of AGEs not only in animal studies but also in patients with diabetic complications and metabolic diseases. This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification. SN - 1178-7007 UR - https://www.unboundmedicine.com/medline/citation/26366100/full_citation L2 - https://dx.doi.org/10.2147/DMSO.S63089 DB - PRIME DP - Unbound Medicine ER -