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Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management.

Abstract

Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesis of several metabolic and degenerative disorders. Accumulating evidence underlies the beneficial effect of the dietary restriction of AGEs not only in animal studies but also in patients with diabetic complications and metabolic diseases. This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification.

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  • Authors+Show Affiliations

    ,

    Endocrine Unit, Medical School University of Athens, Athens, Greece.

    ,

    Endocrine Unit, Medical School University of Athens, Athens, Greece.

    Endocrine Unit, Medical School University of Athens, Athens, Greece.

    Source

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    26366100

    Citation

    Palimeri, Sotiria, et al. "Current Perspectives On the Health Risks Associated With the Consumption of Advanced Glycation End Products: Recommendations for Dietary Management." Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, vol. 8, 2015, pp. 415-26.
    Palimeri S, Palioura E, Diamanti-Kandarakis E. Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management. Diabetes Metab Syndr Obes. 2015;8:415-26.
    Palimeri, S., Palioura, E., & Diamanti-Kandarakis, E. (2015). Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 8, pp. 415-26. doi:10.2147/DMSO.S63089.
    Palimeri S, Palioura E, Diamanti-Kandarakis E. Current Perspectives On the Health Risks Associated With the Consumption of Advanced Glycation End Products: Recommendations for Dietary Management. Diabetes Metab Syndr Obes. 2015;8:415-26. PubMed PMID: 26366100.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management. AU - Palimeri,Sotiria, AU - Palioura,Eleni, AU - Diamanti-Kandarakis,Evanthia, Y1 - 2015/09/01/ PY - 2015/9/15/entrez PY - 2015/9/15/pubmed PY - 2015/9/15/medline KW - AGEs KW - MSR-1 KW - PCOS KW - RAGE KW - dietary glycotoxins KW - dietary restriction SP - 415 EP - 26 JF - Diabetes, metabolic syndrome and obesity : targets and therapy JO - Diabetes Metab Syndr Obes VL - 8 N2 - Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesis of several metabolic and degenerative disorders. Accumulating evidence underlies the beneficial effect of the dietary restriction of AGEs not only in animal studies but also in patients with diabetic complications and metabolic diseases. This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification. SN - 1178-7007 UR - https://www.unboundmedicine.com/medline/citation/26366100/full_citation L2 - https://dx.doi.org/10.2147/DMSO.S63089 DB - PRIME DP - Unbound Medicine ER -