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Egg consumption and risk of heart failure, myocardial infarction, and stroke: results from 2 prospective cohorts.

Abstract

BACKGROUND

Some studies have found that egg consumption is associated with a higher risk of ischemic heart disease in patients with diabetes. Epidemiologic studies of egg consumption in relation to risk of heart failure (HF) and stroke types are scarce.

OBJECTIVE

The aim of this study was to examine whether egg consumption is associated with incidence of HF, myocardial infarction (MI), or stroke types.

DESIGN

In prospective cohorts of 37,766 men (Cohort of Swedish Men) and 32,805 women (Swedish Mammography Cohort) who were free of cardiovascular disease (CVD), egg consumption was assessed at baseline with a food-frequency questionnaire. Incident CVD cases were identified through linkage with the Swedish National Patient and Cause of Death Registers. The data were analyzed with the use of a Cox proportional hazards regression model.

RESULTS

During 13 y of follow-up, we ascertained 1628 HFs, 3262 MIs, 2039 ischemic strokes, and 405 hemorrhagic strokes in men and 1207 HFs, 1504 MIs, 1561 ischemic strokes, and 294 hemorrhagic strokes in women. There was no statistically significant association between egg consumption and risk of MI or any stroke type in either men or women or HF in women. In men, consumption of ≤6 eggs/wk was not associated with HF risk; however, daily egg consumption (≥1/d) was associated with a 30% higher risk of HF (RR: 1.30; 95% CI: 1.01, 1.67). Egg consumption was not associated with any CVD outcome in individuals with diabetes.

CONCLUSIONS

Daily egg consumption was not associated with risk of MI or any stroke type in either men or women or with HF in women. Consumption of eggs ≥1 time/d, but not less frequent consumption, was associated with an elevated risk of HF in men.

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  • Authors+Show Affiliations

    ,

    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden susanna.larsson@ki.se.

    ,

    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

    Source

    MeSH

    Aged
    Brain Ischemia
    Cohort Studies
    Diet
    Diet Surveys
    Eggs
    Female
    Follow-Up Studies
    Heart Failure
    Hemorrhagic Disorders
    Humans
    Incidence
    Male
    Middle Aged
    Myocardial Infarction
    Proportional Hazards Models
    Prospective Studies
    Registries
    Risk Factors
    Sex Factors
    Stroke
    Sweden

    Pub Type(s)

    Journal Article
    Observational Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26399866

    Citation

    Larsson, Susanna C., et al. "Egg Consumption and Risk of Heart Failure, Myocardial Infarction, and Stroke: Results From 2 Prospective Cohorts." The American Journal of Clinical Nutrition, vol. 102, no. 5, 2015, pp. 1007-13.
    Larsson SC, Åkesson A, Wolk A. Egg consumption and risk of heart failure, myocardial infarction, and stroke: results from 2 prospective cohorts. Am J Clin Nutr. 2015;102(5):1007-13.
    Larsson, S. C., Åkesson, A., & Wolk, A. (2015). Egg consumption and risk of heart failure, myocardial infarction, and stroke: results from 2 prospective cohorts. The American Journal of Clinical Nutrition, 102(5), pp. 1007-13. doi:10.3945/ajcn.115.119263.
    Larsson SC, Åkesson A, Wolk A. Egg Consumption and Risk of Heart Failure, Myocardial Infarction, and Stroke: Results From 2 Prospective Cohorts. Am J Clin Nutr. 2015;102(5):1007-13. PubMed PMID: 26399866.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Egg consumption and risk of heart failure, myocardial infarction, and stroke: results from 2 prospective cohorts. AU - Larsson,Susanna C, AU - Åkesson,Agneta, AU - Wolk,Alicja, Y1 - 2015/09/23/ PY - 2015/07/13/received PY - 2015/08/21/accepted PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/2/9/medline KW - cardiovascular disease KW - cholesterol KW - eggs KW - heart failure KW - myocardial infarction KW - prospective studies KW - stroke SP - 1007 EP - 13 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 102 IS - 5 N2 - BACKGROUND: Some studies have found that egg consumption is associated with a higher risk of ischemic heart disease in patients with diabetes. Epidemiologic studies of egg consumption in relation to risk of heart failure (HF) and stroke types are scarce. OBJECTIVE: The aim of this study was to examine whether egg consumption is associated with incidence of HF, myocardial infarction (MI), or stroke types. DESIGN: In prospective cohorts of 37,766 men (Cohort of Swedish Men) and 32,805 women (Swedish Mammography Cohort) who were free of cardiovascular disease (CVD), egg consumption was assessed at baseline with a food-frequency questionnaire. Incident CVD cases were identified through linkage with the Swedish National Patient and Cause of Death Registers. The data were analyzed with the use of a Cox proportional hazards regression model. RESULTS: During 13 y of follow-up, we ascertained 1628 HFs, 3262 MIs, 2039 ischemic strokes, and 405 hemorrhagic strokes in men and 1207 HFs, 1504 MIs, 1561 ischemic strokes, and 294 hemorrhagic strokes in women. There was no statistically significant association between egg consumption and risk of MI or any stroke type in either men or women or HF in women. In men, consumption of ≤6 eggs/wk was not associated with HF risk; however, daily egg consumption (≥1/d) was associated with a 30% higher risk of HF (RR: 1.30; 95% CI: 1.01, 1.67). Egg consumption was not associated with any CVD outcome in individuals with diabetes. CONCLUSIONS: Daily egg consumption was not associated with risk of MI or any stroke type in either men or women or with HF in women. Consumption of eggs ≥1 time/d, but not less frequent consumption, was associated with an elevated risk of HF in men. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26399866/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.119263 DB - PRIME DP - Unbound Medicine ER -