Tags

Type your tag names separated by a space and hit enter

Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.

Abstract

BACKGROUND

Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.

OBJECTIVE

The objective of this study was to conduct a pooled analysis of the associations of the concentrations of 7 carotenoids, retinol, α-tocopherol, and γ-tocopherol with risk of prostate cancer and to describe whether any associations differ by stage or grade of the disease or other factors.

DESIGN

Principal investigators of prospective studies provided individual participant data for prostate cancer cases and controls. Risk by study-specific fifths of each biomarker was estimated by using multivariable-adjusted conditional logistic regression in matched case-control sets.

RESULTS

Data were available for up to 11,239 cases (including 1654 advanced stage and 1741 aggressive) and 18,541 controls from 15 studies. Lycopene was not associated with overall risk of prostate cancer, but there was statistically significant heterogeneity by stage of disease, and the OR for aggressive disease for the highest compared with the lowest fifth of lycopene was 0.65 (95% CI: 0.46, 0.91; P-trend = 0.032). No other carotenoid was significantly associated with overall risk of prostate cancer or with risk of advanced-stage or aggressive disease. For retinol, the OR for the highest compared with the lowest fifth was 1.13 (95% CI: 1.04, 1.22; P-trend = 0.015). For α-tocopherol, the OR for the highest compared with the lowest fifth was 0.86 (95% CI: 0.78, 0.94; P-trend < 0.001), with significant heterogeneity by stage of disease; the OR for aggressive prostate cancer was 0.74 (95% CI: 0.59, 0.92; P-trend = 0.001). γ-Tocopherol was not associated with risk.

CONCLUSIONS

Overall prostate cancer risk was positively associated with retinol and inversely associated with α-tocopherol, and risk of aggressive prostate cancer was inversely associated with lycopene and α-tocopherol. Whether these associations reflect causal relations is unclear.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Cancer Epidemiology Unit, Nuffield Department of Population Health, tim.key@ceu.ox.ac.uk.

    ,

    Cancer Epidemiology Unit, Nuffield Department of Population Health.

    ,

    Cancer Epidemiology Unit, Nuffield Department of Population Health.

    ,

    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;

    ,

    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC;

    ,

    Navarre Public Health Institute, Pamplona, Spain, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Spain;

    ,

    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;

    ,

    Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany;

    ,

    National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands; School of Public Health, Imperial College, London, United Kingdom;

    ,

    Departments of Epidemiology & Biostatistics and Urology, University of California, San Francisco, San Francisco, CA;

    ,

    Public Health Sciences Division, Program in Epidemiology.

    ,

    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;

    ,

    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;

    ,

    Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;

    ,

    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;

    ,

    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;

    ,

    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;

    ,

    Departments of Epidemiology and Environmental Health, University of Washington, Seattle, WA;

    ,

    SWOG Statistical Center.

    ,

    School of Public Health, Imperial College, London, United Kingdom;

    ,

    Department of Surgery, and.

    ,

    National Institute for Health and Welfare, Helsinki, Finland;

    ,

    Prevention and Research Center Mercy Medical Center, Baltimore, MD;

    ,

    Keck School of Medicine, University of Southern California, Los Angeles, CA;

    ,

    Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;

    ,

    George W Comstock Center for Public Health Research and Prevention, Hagerstown, MD;

    ,

    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;

    ,

    International Agency for Research on Cancer, Lyon, France; Department for Biobank Research, Umeå University, Umeå, Sweden;

    ,

    Department of Public Health and Primary Care and.

    ,

    Public Health Sciences Core Laboratories, Department of Internal Medicine, University of New Mexico, Albuquerque, NM.

    ,

    National Institute for Health and Welfare, Helsinki, Finland;

    ,

    University of Hawaii Cancer Center, Honolulu, HI;

    ,

    University of Hawaii Cancer Center, Honolulu, HI;

    ,

    National Institute for Health and Welfare, Helsinki, Finland;

    ,

    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom;

    ,

    Department of Community Medicine, Faculty of Medicine, University of Oslo and Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;

    ,

    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;

    ,

    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;

    ,

    Department of Oncology, University of Cambridge, Cambridge, United Kingdom;

    ,

    Division of Public Health Sciences, and.

    ,

    Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy;

    ,

    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD;

    ,

    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;

    ,

    National Institute for Health and Welfare, Helsinki, Finland;

    ,

    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA;

    ,

    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;

    ,

    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;

    ,

    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;

    ,

    Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;

    ,

    Hellenic Health Foundation and Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece and.

    ,

    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;

    ,

    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;

    ,

    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;

    ,

    Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;

    Source

    MeSH

    Adult
    Biomarkers
    Carotenoids
    Case-Control Studies
    Cohort Studies
    Cross-Sectional Studies
    Humans
    Lycopene
    Male
    Meta-Analysis as Topic
    Middle Aged
    Neoplasm Grading
    Neoplasm Staging
    Observational Studies as Topic
    Prospective Studies
    Prostate
    Prostatic Neoplasms
    Risk Factors
    Vitamin A
    alpha-Tocopherol

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26447150

    Citation

    Key, Timothy J., et al. "Carotenoids, Retinol, Tocopherols, and Prostate Cancer Risk: Pooled Analysis of 15 Studies." The American Journal of Clinical Nutrition, vol. 102, no. 5, 2015, pp. 1142-57.
    Key TJ, Appleby PN, Travis RC, et al. Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. Am J Clin Nutr. 2015;102(5):1142-57.
    Key, T. J., Appleby, P. N., Travis, R. C., Albanes, D., Alberg, A. J., Barricarte, A., ... Allen, N. E. (2015). Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. The American Journal of Clinical Nutrition, 102(5), pp. 1142-57. doi:10.3945/ajcn.115.114306.
    Key TJ, et al. Carotenoids, Retinol, Tocopherols, and Prostate Cancer Risk: Pooled Analysis of 15 Studies. Am J Clin Nutr. 2015;102(5):1142-57. PubMed PMID: 26447150.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. AU - Key,Timothy J, AU - Appleby,Paul N, AU - Travis,Ruth C, AU - Albanes,Demetrius, AU - Alberg,Anthony J, AU - Barricarte,Aurelio, AU - Black,Amanda, AU - Boeing,Heiner, AU - Bueno-de-Mesquita,H Bas, AU - Chan,June M, AU - Chen,Chu, AU - Cook,Michael B, AU - Donovan,Jenny L, AU - Galan,Pilar, AU - Gilbert,Rebecca, AU - Giles,Graham G, AU - Giovannucci,Edward, AU - Goodman,Gary E, AU - Goodman,Phyllis J, AU - Gunter,Marc J, AU - Hamdy,Freddie C, AU - Heliövaara,Markku, AU - Helzlsouer,Kathy J, AU - Henderson,Brian E, AU - Hercberg,Serge, AU - Hoffman-Bolton,Judy, AU - Hoover,Robert N, AU - Johansson,Mattias, AU - Khaw,Kay-Tee, AU - King,Irena B, AU - Knekt,Paul, AU - Kolonel,Laurence N, AU - Le Marchand,Loic, AU - Männistö,Satu, AU - Martin,Richard M, AU - Meyer,Haakon E, AU - Mondul,Alison M, AU - Moy,Kristin A, AU - Neal,David E, AU - Neuhouser,Marian L, AU - Palli,Domenico, AU - Platz,Elizabeth A, AU - Pouchieu,Camille, AU - Rissanen,Harri, AU - Schenk,Jeannette M, AU - Severi,Gianluca, AU - Stampfer,Meir J, AU - Tjønneland,Anne, AU - Touvier,Mathilde, AU - Trichopoulou,Antonia, AU - Weinstein,Stephanie J, AU - Ziegler,Regina G, AU - Zhou,Cindy Ke, AU - Allen,Naomi E, AU - ,, Y1 - 2015/10/07/ PY - 2015/05/01/received PY - 2015/09/01/accepted PY - 2015/10/9/entrez PY - 2015/10/9/pubmed PY - 2016/2/9/medline KW - biomarkers KW - carotenoids KW - nested case-control study KW - pooled analysis KW - prostate cancer KW - retinol KW - tocopherols KW - vitamin A KW - vitamin E SP - 1142 EP - 57 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 102 IS - 5 N2 - BACKGROUND: Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease. OBJECTIVE: The objective of this study was to conduct a pooled analysis of the associations of the concentrations of 7 carotenoids, retinol, α-tocopherol, and γ-tocopherol with risk of prostate cancer and to describe whether any associations differ by stage or grade of the disease or other factors. DESIGN: Principal investigators of prospective studies provided individual participant data for prostate cancer cases and controls. Risk by study-specific fifths of each biomarker was estimated by using multivariable-adjusted conditional logistic regression in matched case-control sets. RESULTS: Data were available for up to 11,239 cases (including 1654 advanced stage and 1741 aggressive) and 18,541 controls from 15 studies. Lycopene was not associated with overall risk of prostate cancer, but there was statistically significant heterogeneity by stage of disease, and the OR for aggressive disease for the highest compared with the lowest fifth of lycopene was 0.65 (95% CI: 0.46, 0.91; P-trend = 0.032). No other carotenoid was significantly associated with overall risk of prostate cancer or with risk of advanced-stage or aggressive disease. For retinol, the OR for the highest compared with the lowest fifth was 1.13 (95% CI: 1.04, 1.22; P-trend = 0.015). For α-tocopherol, the OR for the highest compared with the lowest fifth was 0.86 (95% CI: 0.78, 0.94; P-trend < 0.001), with significant heterogeneity by stage of disease; the OR for aggressive prostate cancer was 0.74 (95% CI: 0.59, 0.92; P-trend = 0.001). γ-Tocopherol was not associated with risk. CONCLUSIONS: Overall prostate cancer risk was positively associated with retinol and inversely associated with α-tocopherol, and risk of aggressive prostate cancer was inversely associated with lycopene and α-tocopherol. Whether these associations reflect causal relations is unclear. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26447150/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.114306 DB - PRIME DP - Unbound Medicine ER -