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Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases.
Inflamm Bowel Dis. 2016 Jan; 22(1):224-33.IB

Abstract

Low-dose methotrexate (MTX) therapy is a well-recognized therapy for many inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and psoriasis. More than 20 years ago, the clinical efficacy of MTX was also established for steroid dependent Crohn's disease, but it was never broadly adapted as a treatment modality. More recently, MTX is being increasingly used in the pediatric population with Crohn's disease, both as a single agent as well as a concomitant therapy with anti-tumor necrosis factor-alpha treatment. This review outlines important pharmacological aspects for the therapeutic application of MTX and the current status of MTX as mono- or combination-therapy in both pediatric and adult patients with inflammatory bowel disease including new results of MTX monotherapy in steroid dependent ulcerative colitis.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

26457382

Citation

Herfarth, Hans H., et al. "Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases." Inflammatory Bowel Diseases, vol. 22, no. 1, 2016, pp. 224-33.
Herfarth HH, Kappelman MD, Long MD, et al. Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2016;22(1):224-33.
Herfarth, H. H., Kappelman, M. D., Long, M. D., & Isaacs, K. L. (2016). Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases. Inflammatory Bowel Diseases, 22(1), 224-33. https://doi.org/10.1097/MIB.0000000000000589
Herfarth HH, et al. Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2016;22(1):224-33. PubMed PMID: 26457382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases. AU - Herfarth,Hans H, AU - Kappelman,Michael D, AU - Long,Millie D, AU - Isaacs,Kim L, PY - 2015/10/13/entrez PY - 2015/10/13/pubmed PY - 2016/10/19/medline SP - 224 EP - 33 JF - Inflammatory bowel diseases JO - Inflamm Bowel Dis VL - 22 IS - 1 N2 - Low-dose methotrexate (MTX) therapy is a well-recognized therapy for many inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and psoriasis. More than 20 years ago, the clinical efficacy of MTX was also established for steroid dependent Crohn's disease, but it was never broadly adapted as a treatment modality. More recently, MTX is being increasingly used in the pediatric population with Crohn's disease, both as a single agent as well as a concomitant therapy with anti-tumor necrosis factor-alpha treatment. This review outlines important pharmacological aspects for the therapeutic application of MTX and the current status of MTX as mono- or combination-therapy in both pediatric and adult patients with inflammatory bowel disease including new results of MTX monotherapy in steroid dependent ulcerative colitis. SN - 1536-4844 UR - https://www.unboundmedicine.com/medline/citation/26457382/full_citation L2 - https://academic.oup.com/ibdjournal/article-lookup/doi/10.1097/MIB.0000000000000589 DB - PRIME DP - Unbound Medicine ER -