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Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals.

Abstract

INTRODUCTION

Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.

OBJECTIVE

To evaluate the effects of probiotics on human serum lipid levels, we conducted a meta-analysis of interventional studies.

METHODS

Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed.

RESULTS

Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference -0.17 mmol/L, 95% CI: -0.27 to -0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference -0.22 mmol/L, 95% CI: -0.30 to -0.13 mmol/L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-term (> 4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-term (≤ 4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains.

CONCLUSIONS

In conclusion, this meta-analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease.

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  • Authors+Show Affiliations

    ,

    Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-50-30 Shibakoen, Tokyo, 105-8512, Japan.

    ,

    Division for Evaluation and Analysis of Drug Information, Faculty of Pharmacy, Keio University, 1-50-30 Shibakoen, Tokyo, 105-8512, Japan.

    ,

    Department of Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

    ,

    Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-50-30 Shibakoen, Tokyo, 105-8512, Japan.

    Division for Evaluation and Analysis of Drug Information, Faculty of Pharmacy, Keio University, 1-50-30 Shibakoen, Tokyo, 105-8512, Japan.

    Source

    PloS one 10:10 2015 pg e0139795

    MeSH

    Cholesterol, LDL
    Dietary Supplements
    Female
    Humans
    Hypercholesterolemia
    Male
    Probiotics
    PubMed
    Randomized Controlled Trials as Topic

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26473340

    Citation

    Shimizu, Mikiko, et al. "Meta-Analysis: Effects of Probiotic Supplementation On Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals." PloS One, vol. 10, no. 10, 2015, pp. e0139795.
    Shimizu M, Hashiguchi M, Shiga T, et al. Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals. PLoS ONE. 2015;10(10):e0139795.
    Shimizu, M., Hashiguchi, M., Shiga, T., Tamura, H. O., & Mochizuki, M. (2015). Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals. PloS One, 10(10), pp. e0139795. doi:10.1371/journal.pone.0139795.
    Shimizu M, et al. Meta-Analysis: Effects of Probiotic Supplementation On Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals. PLoS ONE. 2015;10(10):e0139795. PubMed PMID: 26473340.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals. AU - Shimizu,Mikiko, AU - Hashiguchi,Masayuki, AU - Shiga,Tsuyoshi, AU - Tamura,Hiro-omi, AU - Mochizuki,Mayumi, Y1 - 2015/10/16/ PY - 2014/08/08/received PY - 2015/09/17/accepted PY - 2015/10/17/entrez PY - 2015/10/17/pubmed PY - 2016/6/3/medline SP - e0139795 EP - e0139795 JF - PloS one JO - PLoS ONE VL - 10 IS - 10 N2 - INTRODUCTION: Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol. OBJECTIVE: To evaluate the effects of probiotics on human serum lipid levels, we conducted a meta-analysis of interventional studies. METHODS: Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed. RESULTS: Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference -0.17 mmol/L, 95% CI: -0.27 to -0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference -0.22 mmol/L, 95% CI: -0.30 to -0.13 mmol/L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-term (> 4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-term (≤ 4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains. CONCLUSIONS: In conclusion, this meta-analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26473340/full_citation L2 - http://dx.plos.org/10.1371/journal.pone.0139795 DB - PRIME DP - Unbound Medicine ER -