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Investigating the Association Between Periodontal Disease and Risk of Pancreatic Cancer.

Abstract

OBJECTIVE

Periodontal disease (PD) is increasingly recognized as an emerging risk factor for various systemic diseases, including diabetes, cardiovascular diseases, and cancer. The current study examined the association between PD (periodontitis, gingivitis, and others) and pancreatic cancer.

METHODS

A total of 139,805 subjects with PD and 75,085 subjects without PD were identified from the National Health Insurance Research Database of Taiwan. Cox proportional hazards regression was performed to compare the incidence of pancreatic cancer between the 2 groups.

RESULTS

Periodontal disease was positively associated with pancreatic cancer risk (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.02-2.33). This positive association occurred predominantly among those aged 65 years or older (HR, 2.17; 95% CI, 1.03-4.57) and was not observed among those aged younger than 65 years (HR, 0.83; 95% CI, 0.52-1.34). Further analysis showed that PD is a risk factor for pancreatic cancer independent of diabetes, hyperlipidemia, allergies, viral hepatitis, peptic ulcer, pancreatitis, chronic obstructive pulmonary disease (as a proxy for cigarette smoking), and alcoholic-related conditions (as a proxy for alcohol drinking).

CONCLUSIONS

Our results indicated a significantly positive association between PD and risk of pancreatic cancer. The underlying biological mechanisms for the positive association between PD and pancreatic cancer require further investigation.

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  • Authors+Show Affiliations

    ,

    From the *National Institute of Cancer Research, National Health Research Institutes; †Department of Internal Medicine, National Cheng Kung University Hospital, Tainan; ‡Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung; §Institute of Molecular Medicine, National Cheng Kung University, Tainan; ∥Department of Surgery, National Cheng Kung University, College of Medicine; and ¶Institute of Clinical Medicine, National Cheng Kung University, College of Medicine, Tainan, Taiwan.

    , ,

    Source

    Pancreas 45:1 2016 Jan pg 134-41

    MeSH

    Adult
    Age Factors
    Aged
    Chi-Square Distribution
    Databases, Factual
    Female
    Gingivitis
    Humans
    Incidence
    Logistic Models
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Pancreatic Neoplasms
    Periodontitis
    Proportional Hazards Models
    Retrospective Studies
    Risk Assessment
    Risk Factors
    Taiwan

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26474422

    Citation

    Chang, Jeffrey S., et al. "Investigating the Association Between Periodontal Disease and Risk of Pancreatic Cancer." Pancreas, vol. 45, no. 1, 2016, pp. 134-41.
    Chang JS, Tsai CR, Chen LT, et al. Investigating the Association Between Periodontal Disease and Risk of Pancreatic Cancer. Pancreas. 2016;45(1):134-41.
    Chang, J. S., Tsai, C. R., Chen, L. T., & Shan, Y. S. (2016). Investigating the Association Between Periodontal Disease and Risk of Pancreatic Cancer. Pancreas, 45(1), pp. 134-41. doi:10.1097/MPA.0000000000000419.
    Chang JS, et al. Investigating the Association Between Periodontal Disease and Risk of Pancreatic Cancer. Pancreas. 2016;45(1):134-41. PubMed PMID: 26474422.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Investigating the Association Between Periodontal Disease and Risk of Pancreatic Cancer. AU - Chang,Jeffrey S, AU - Tsai,Chia-Rung, AU - Chen,Li-Tzong, AU - Shan,Yan-Shen, PY - 2015/10/17/entrez PY - 2015/10/17/pubmed PY - 2016/9/20/medline SP - 134 EP - 41 JF - Pancreas JO - Pancreas VL - 45 IS - 1 N2 - OBJECTIVE: Periodontal disease (PD) is increasingly recognized as an emerging risk factor for various systemic diseases, including diabetes, cardiovascular diseases, and cancer. The current study examined the association between PD (periodontitis, gingivitis, and others) and pancreatic cancer. METHODS: A total of 139,805 subjects with PD and 75,085 subjects without PD were identified from the National Health Insurance Research Database of Taiwan. Cox proportional hazards regression was performed to compare the incidence of pancreatic cancer between the 2 groups. RESULTS: Periodontal disease was positively associated with pancreatic cancer risk (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.02-2.33). This positive association occurred predominantly among those aged 65 years or older (HR, 2.17; 95% CI, 1.03-4.57) and was not observed among those aged younger than 65 years (HR, 0.83; 95% CI, 0.52-1.34). Further analysis showed that PD is a risk factor for pancreatic cancer independent of diabetes, hyperlipidemia, allergies, viral hepatitis, peptic ulcer, pancreatitis, chronic obstructive pulmonary disease (as a proxy for cigarette smoking), and alcoholic-related conditions (as a proxy for alcohol drinking). CONCLUSIONS: Our results indicated a significantly positive association between PD and risk of pancreatic cancer. The underlying biological mechanisms for the positive association between PD and pancreatic cancer require further investigation. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/26474422/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=26474422 DB - PRIME DP - Unbound Medicine ER -