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Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine.
Age (Dordr). 2015 Dec; 37(6):105.A

Abstract

We aimed to verify whether different levels of training performed regularly and voluntarily for many years could have an impact on one of the main issues of immunosenescence: the poor response to vaccines. We recruited 61 healthy elderly men (65-85 years old), 23 with a moderate training (MT) lifestyle (for 17.0 ± 3.2 years), 22 with an intense training (IT) lifestyle (for 25.9 ± 3.4 years), and 16 without a training lifestyle (NT). Fitness was evaluated through the IPAQ and VO2max consumption. The participants were evaluated regarding cognitive aspects, nutritional status, depression, and quality of life. Antibody titers were determined by hemagglutination inhibition assay prior to influenza vaccination and at 6 weeks and 6 months post-vaccination. Strains used were B, H3N2, and H1N1. Our groups were matched for most characteristics, except for those directly influenced by their lifestyles, such as BMI, VO2max, and MET. In general, MT and IT elderly men showed significantly higher antibody titers to the three vaccine strains post-vaccination than NT elderly men. There were also higher titers against B and H1N1 strains in the trained groups before vaccination. Additionally, there were higher proportions of seroprotected (titers ≥1:40) individuals in the pooled trained groups both at 6 weeks (B and H3N2, p < 0.05) and 6 months (H1N1, p < 0.05; B, p = 0.07). There were no significant differences between the MT and IT groups. Either a moderate or an intense training is associated with stronger and longstanding antibody responses to the influenza vaccine, resulting in higher percentages of seroprotected individuals.

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Authors+Show Affiliations

de Araújo AL
Laboratory of Dermatology and Immunodeficiencies, Dermatology Division, Clinics Hospital, R. Dr. Eneas de Carvalho Aguiar, 470, Cerqueira Cesar, São Paulo, 05403-903, São Paulo, Brazil.
Silva LC
Laboratory of Dermatology and Immunodeficiencies, Dermatology Division, Clinics Hospital, R. Dr. Eneas de Carvalho Aguiar, 470, Cerqueira Cesar, São Paulo, 05403-903, São Paulo, Brazil.
Fernandes JR
Laboratory of Dermatology and Immunodeficiencies, Dermatology Division, Clinics Hospital, R. Dr. Eneas de Carvalho Aguiar, 470, Cerqueira Cesar, São Paulo, 05403-903, São Paulo, Brazil.
Matias Mde S
Department of Orthopedics and Traumatology, School of Medicine, USP-São Paulo, SP, Brazil.
Boas LS
Virology Laboratory, Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
Machado CM
Virology Laboratory, Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
Garcez-Leme LE
Department of Orthopedics and Traumatology, School of Medicine, USP-São Paulo, SP, Brazil.
Benard G
Laboratory of Dermatology and Immunodeficiencies, Dermatology Division, Clinics Hospital, R. Dr. Eneas de Carvalho Aguiar, 470, Cerqueira Cesar, São Paulo, 05403-903, São Paulo, Brazil. mahong@usp.br. Medical Mycology Laboratory, Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil. mahong@usp.br.

MeSH

AgedAged, 80 and overAgingAntibodies, ViralAntibody FormationCross-Sectional StudiesExerciseHemagglutination Inhibition TestsHumansInfluenza VaccinesInfluenza, HumanLife StyleMale

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26480853

Citation

de Araújo, Adriana Ladeira, et al. "Elderly Men With Moderate and Intense Training Lifestyle Present Sustained Higher Antibody Responses to Influenza Vaccine." Age (Dordrecht, Netherlands), vol. 37, no. 6, 2015, p. 105.
de Araújo AL, Silva LC, Fernandes JR, et al. Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine. Age (Dordr). 2015;37(6):105.
de Araújo, A. L., Silva, L. C., Fernandes, J. R., Matias, M. d. e. . S., Boas, L. S., Machado, C. M., Garcez-Leme, L. E., & Benard, G. (2015). Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine. Age (Dordrecht, Netherlands), 37(6), 105. https://doi.org/10.1007/s11357-015-9843-4
de Araújo AL, et al. Elderly Men With Moderate and Intense Training Lifestyle Present Sustained Higher Antibody Responses to Influenza Vaccine. Age (Dordr). 2015;37(6):105. PubMed PMID: 26480853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine. AU - de Araújo,Adriana Ladeira, AU - Silva,Léia Cristina Rodrigues, AU - Fernandes,Juliana Ruiz, AU - Matias,Manuella de Sousa Toledo, AU - Boas,Lucy Santos, AU - Machado,Clarisse Martins, AU - Garcez-Leme,Luiz Eugênio, AU - Benard,Gil, Y1 - 2015/10/19/ PY - 2015/06/16/received PY - 2015/10/07/accepted PY - 2015/10/21/entrez PY - 2015/10/21/pubmed PY - 2016/8/9/medline KW - Antibody response KW - Exercise KW - Influenza KW - Lifestyle KW - Vaccine SP - 105 EP - 105 JF - Age (Dordrecht, Netherlands) JO - Age (Dordr) VL - 37 IS - 6 N2 - We aimed to verify whether different levels of training performed regularly and voluntarily for many years could have an impact on one of the main issues of immunosenescence: the poor response to vaccines. We recruited 61 healthy elderly men (65-85 years old), 23 with a moderate training (MT) lifestyle (for 17.0 ± 3.2 years), 22 with an intense training (IT) lifestyle (for 25.9 ± 3.4 years), and 16 without a training lifestyle (NT). Fitness was evaluated through the IPAQ and VO2max consumption. The participants were evaluated regarding cognitive aspects, nutritional status, depression, and quality of life. Antibody titers were determined by hemagglutination inhibition assay prior to influenza vaccination and at 6 weeks and 6 months post-vaccination. Strains used were B, H3N2, and H1N1. Our groups were matched for most characteristics, except for those directly influenced by their lifestyles, such as BMI, VO2max, and MET. In general, MT and IT elderly men showed significantly higher antibody titers to the three vaccine strains post-vaccination than NT elderly men. There were also higher titers against B and H1N1 strains in the trained groups before vaccination. Additionally, there were higher proportions of seroprotected (titers ≥1:40) individuals in the pooled trained groups both at 6 weeks (B and H3N2, p < 0.05) and 6 months (H1N1, p < 0.05; B, p = 0.07). There were no significant differences between the MT and IT groups. Either a moderate or an intense training is associated with stronger and longstanding antibody responses to the influenza vaccine, resulting in higher percentages of seroprotected individuals. SN - 1574-4647 UR - https://www.unboundmedicine.com/medline/citation/26480853/full_citation DB - PRIME DP - Unbound Medicine ER -