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Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study.
Am J Clin Nutr 2015; 102(5):1196-206AJ

Abstract

BACKGROUND

Adherence to a Mediterranean-type diet is linked to a lower risk of mortality and chronic disease, but the association with the progression of age-related macular degeneration (AMD) and genetic susceptibility is unknown.

OBJECTIVE

We examined the association of adherence to the Mediterranean diet and genetic susceptibility with progression to advanced AMD.

DESIGN

Among 2525 subjects in the AREDS (Age-Related Eye Disease Study), 1028 eyes progressed to advanced AMD over 13 y. Baseline data for demographic and behavioral covariates were collected by using questionnaires. Dietary data were collected from food-frequency questionnaires. The alternate Mediterranean diet (aMeDi) score (range: 0-9) was constructed from individual intakes of vegetables, fruit, legumes, whole grains, nuts, fish, red and processed meats, alcohol, and the ratio of monounsaturated to saturated fats. Ten genetic loci in 7 genes [complement factor H (CFH), age-related maculopathy susceptibility 2/high-temperature requirement A serine peptidase 1 (ARMS2/HTRA1), complement component 2 (C2), complement factor B (CFB), complement component 3 (C3), collagen type VIII α 1 (COL8A1), and RAD51 paralog B (RAD51B)] were examined. Survival analysis was used to assess individual eyes for associations between incident AMD and aMeDi score, as well as interaction effects between aMeDi score and genetic variation on risk of AMD.

RESULTS

A high aMeDi score (score of 6-9) was significantly associated with a reduced risk of progression to advanced AMD after adjustment for demographic, behavioral, ocular, and genetic covariates (HR: 0.74; 95% CI: 0.61, 0.91; P-trend = 0.007). The aMeDi score was significantly associated with a lower risk of incident advanced AMD among subjects carrying the CFH Y402H nonrisk (T) allele (P-trend = 0.0004, P-interaction = 0.04). The aMeDi score was not associated with AMD among subjects who were homozygous for the risk (C) allele.

CONCLUSION

Higher adherence to a Mediterranean diet was associated with reduced risk of progression to advanced AMD, which may be modified by genetic susceptibility. This trial was registered at clinicaltrials.gov as NCT00594672.

Authors+Show Affiliations

Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA;Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA;Channing Division of Network Medicine, Harvard Medical School, Harvard University, Boston, MA.Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA; jseddon@tuftsmedicalcenter.org.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26490493

Citation

Merle, Bénédicte M J., et al. "Adherence to a Mediterranean Diet, Genetic Susceptibility, and Progression to Advanced Macular Degeneration: a Prospective Cohort Study." The American Journal of Clinical Nutrition, vol. 102, no. 5, 2015, pp. 1196-206.
Merle BM, Silver RE, Rosner B, et al. Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study. Am J Clin Nutr. 2015;102(5):1196-206.
Merle, B. M., Silver, R. E., Rosner, B., & Seddon, J. M. (2015). Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study. The American Journal of Clinical Nutrition, 102(5), pp. 1196-206. doi:10.3945/ajcn.115.111047.
Merle BM, et al. Adherence to a Mediterranean Diet, Genetic Susceptibility, and Progression to Advanced Macular Degeneration: a Prospective Cohort Study. Am J Clin Nutr. 2015;102(5):1196-206. PubMed PMID: 26490493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study. AU - Merle,Bénédicte M J, AU - Silver,Rachel E, AU - Rosner,Bernard, AU - Seddon,Johanna M, Y1 - 2015/10/21/ PY - 2015/03/13/received PY - 2015/08/27/accepted PY - 2015/10/23/entrez PY - 2015/10/23/pubmed PY - 2016/2/9/medline KW - AMD progression KW - Mediterranean diet KW - genetics KW - macular degeneration KW - nutrition SP - 1196 EP - 206 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 102 IS - 5 N2 - BACKGROUND: Adherence to a Mediterranean-type diet is linked to a lower risk of mortality and chronic disease, but the association with the progression of age-related macular degeneration (AMD) and genetic susceptibility is unknown. OBJECTIVE: We examined the association of adherence to the Mediterranean diet and genetic susceptibility with progression to advanced AMD. DESIGN: Among 2525 subjects in the AREDS (Age-Related Eye Disease Study), 1028 eyes progressed to advanced AMD over 13 y. Baseline data for demographic and behavioral covariates were collected by using questionnaires. Dietary data were collected from food-frequency questionnaires. The alternate Mediterranean diet (aMeDi) score (range: 0-9) was constructed from individual intakes of vegetables, fruit, legumes, whole grains, nuts, fish, red and processed meats, alcohol, and the ratio of monounsaturated to saturated fats. Ten genetic loci in 7 genes [complement factor H (CFH), age-related maculopathy susceptibility 2/high-temperature requirement A serine peptidase 1 (ARMS2/HTRA1), complement component 2 (C2), complement factor B (CFB), complement component 3 (C3), collagen type VIII α 1 (COL8A1), and RAD51 paralog B (RAD51B)] were examined. Survival analysis was used to assess individual eyes for associations between incident AMD and aMeDi score, as well as interaction effects between aMeDi score and genetic variation on risk of AMD. RESULTS: A high aMeDi score (score of 6-9) was significantly associated with a reduced risk of progression to advanced AMD after adjustment for demographic, behavioral, ocular, and genetic covariates (HR: 0.74; 95% CI: 0.61, 0.91; P-trend = 0.007). The aMeDi score was significantly associated with a lower risk of incident advanced AMD among subjects carrying the CFH Y402H nonrisk (T) allele (P-trend = 0.0004, P-interaction = 0.04). The aMeDi score was not associated with AMD among subjects who were homozygous for the risk (C) allele. CONCLUSION: Higher adherence to a Mediterranean diet was associated with reduced risk of progression to advanced AMD, which may be modified by genetic susceptibility. This trial was registered at clinicaltrials.gov as NCT00594672. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26490493/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.111047 DB - PRIME DP - Unbound Medicine ER -