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Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications.

Abstract

Whether dietary β-carotene and vitamin A intake protect against lung cancer risk is not clear. Therefore, we performed this meta-analysis to investigate the association between them. The related articles were searched using the databases PubMed and the Web of Knowledge up to May 2015. We used the random-effect model to estimate the relative risk (RR) and their 95% CI. Small-study effect was assessed using Egger's test. In total, 19 studies comprising 10,261 lung cancer cases met the inclusion criteria. The pooled RR and their 95% CI was 0.855 (0.739-0.989) for higher category of dietary vitamin A intake and lung cancer risk, especially among Asian populations and in the cohort studies. Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).The associations were also significant in American and Asian populations. In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer. However, the dose-response analysis was not performed due to the limited data in each individual study. Due to this limitation, further studies with detailed dose, cases and person-years for β-carotene and vitamin A of each category are wanted to assess this dose-response association.

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  • Authors+Show Affiliations

    ,

    Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. nayu888@yeah.net.

    ,

    Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. xinmingsu123@yeah.net.

    ,

    Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. zanfengwang123@yeah.net.

    ,

    Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. bingdai123@yeah.net.

    Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. kangjian58@163.com.

    Source

    Nutrients 7:11 2015 Nov 11 pg 9309-24

    MeSH

    Animals
    Databases, Factual
    Diet
    Disease Models, Animal
    Humans
    Lung Neoplasms
    Risk Factors
    Sensitivity and Specificity
    Vitamin A
    beta Carotene

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    26569298

    Citation

    Yu, Na, et al. "Association of Dietary Vitamin a and β-Carotene Intake With the Risk of Lung Cancer: a Meta-Analysis of 19 Publications." Nutrients, vol. 7, no. 11, 2015, pp. 9309-24.
    Yu N, Su X, Wang Z, et al. Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications. Nutrients. 2015;7(11):9309-24.
    Yu, N., Su, X., Wang, Z., Dai, B., & Kang, J. (2015). Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications. Nutrients, 7(11), pp. 9309-24. doi:10.3390/nu7115463.
    Yu N, et al. Association of Dietary Vitamin a and β-Carotene Intake With the Risk of Lung Cancer: a Meta-Analysis of 19 Publications. Nutrients. 2015 Nov 11;7(11):9309-24. PubMed PMID: 26569298.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications. AU - Yu,Na, AU - Su,Xinming, AU - Wang,Zanfeng, AU - Dai,Bing, AU - Kang,Jian, Y1 - 2015/11/11/ PY - 2015/07/31/received PY - 2015/10/18/revised PY - 2015/10/27/accepted PY - 2015/11/17/entrez PY - 2015/11/17/pubmed PY - 2016/8/31/medline KW - lung cancer KW - meta-analysis KW - vitamin A KW - β-carotene SP - 9309 EP - 24 JF - Nutrients JO - Nutrients VL - 7 IS - 11 N2 - Whether dietary β-carotene and vitamin A intake protect against lung cancer risk is not clear. Therefore, we performed this meta-analysis to investigate the association between them. The related articles were searched using the databases PubMed and the Web of Knowledge up to May 2015. We used the random-effect model to estimate the relative risk (RR) and their 95% CI. Small-study effect was assessed using Egger's test. In total, 19 studies comprising 10,261 lung cancer cases met the inclusion criteria. The pooled RR and their 95% CI was 0.855 (0.739-0.989) for higher category of dietary vitamin A intake and lung cancer risk, especially among Asian populations and in the cohort studies. Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).The associations were also significant in American and Asian populations. In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer. However, the dose-response analysis was not performed due to the limited data in each individual study. Due to this limitation, further studies with detailed dose, cases and person-years for β-carotene and vitamin A of each category are wanted to assess this dose-response association. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26569298/full_citation L2 - http://www.mdpi.com/resolver?pii=nu7115463 DB - PRIME DP - Unbound Medicine ER -