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The role of zinc in liver cirrhosis.
Ann Hepatol 2016 Jan-Feb; 15(1):7-16AH

Abstract

Zinc is an essential trace element playing fundamental roles in cellular metabolism. It acts mostly by binding a wide range of proteins, thus affecting a broad spectrum of biological processes, which include cell division, growth and differentiation. Zinc is critical to a large number of structural proteins, enzymatic processes, and transcription factors. Zinc deficiency can result in a spectrum of clinical manifestations, such as poor of appetite, loss of body hair, altered taste and smell, testicular atrophy, cerebral and immune dysfunction, and diminished drug elimination capacity. These are common symptoms in patients with chronic liver diseases, especially liver cirrhosis. The liver is the main organ responsible for the zinc metabolism which can be affected by liver diseases. On the other hand, zinc deficiency may alter hepatocyte functions and also immune responses in inflammatory liver diseases. Liver cirrhosis represents the most advanced stage of chronic liver diseases and is the common outcome of chronic liver injury. It is associated with energy malnutrition, with numerous metabolic disorders, such as hypoalbuminemia, with imbalance between branched-chain amino acids and aromatic amino acids, and with reduced zinc serum concentrations. All these processes can influence the clinical outcome of patients, such ascites, hepatic encephalopathy and hepatocellular carcinoma. In the present review, we summarize the emerging evidence on the pitoval role of zinc in the pathogenesis of liver cirrhosis.

Authors+Show Affiliations

Practice of Hepatology, Heydeckstr. 9, Magdeburg, Germany.Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26626635

Citation

Grüngreiff, Kurt, et al. "The Role of Zinc in Liver Cirrhosis." Annals of Hepatology, vol. 15, no. 1, 2016, pp. 7-16.
Grüngreiff K, Reinhold D, Wedemeyer H. The role of zinc in liver cirrhosis. Ann Hepatol. 2016;15(1):7-16.
Grüngreiff, K., Reinhold, D., & Wedemeyer, H. (2016). The role of zinc in liver cirrhosis. Annals of Hepatology, 15(1), pp. 7-16.
Grüngreiff K, Reinhold D, Wedemeyer H. The Role of Zinc in Liver Cirrhosis. Ann Hepatol. 2016;15(1):7-16. PubMed PMID: 26626635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of zinc in liver cirrhosis. AU - Grüngreiff,Kurt, AU - Reinhold,Dirk, AU - Wedemeyer,Heiner, PY - 2015/12/3/entrez PY - 2015/12/3/pubmed PY - 2016/9/20/medline SP - 7 EP - 16 JF - Annals of hepatology JO - Ann Hepatol VL - 15 IS - 1 N2 - Zinc is an essential trace element playing fundamental roles in cellular metabolism. It acts mostly by binding a wide range of proteins, thus affecting a broad spectrum of biological processes, which include cell division, growth and differentiation. Zinc is critical to a large number of structural proteins, enzymatic processes, and transcription factors. Zinc deficiency can result in a spectrum of clinical manifestations, such as poor of appetite, loss of body hair, altered taste and smell, testicular atrophy, cerebral and immune dysfunction, and diminished drug elimination capacity. These are common symptoms in patients with chronic liver diseases, especially liver cirrhosis. The liver is the main organ responsible for the zinc metabolism which can be affected by liver diseases. On the other hand, zinc deficiency may alter hepatocyte functions and also immune responses in inflammatory liver diseases. Liver cirrhosis represents the most advanced stage of chronic liver diseases and is the common outcome of chronic liver injury. It is associated with energy malnutrition, with numerous metabolic disorders, such as hypoalbuminemia, with imbalance between branched-chain amino acids and aromatic amino acids, and with reduced zinc serum concentrations. All these processes can influence the clinical outcome of patients, such ascites, hepatic encephalopathy and hepatocellular carcinoma. In the present review, we summarize the emerging evidence on the pitoval role of zinc in the pathogenesis of liver cirrhosis. SN - 1665-2681 UR - https://www.unboundmedicine.com/medline/citation/26626635/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1665-2681(19)30735-5 DB - PRIME DP - Unbound Medicine ER -