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Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon.

Abstract

There has been an unprecedented worldwide rise in non-communicable metabolic diseases (NCDs), particularly cardiovascular diseases (CVD) and diabetes. While modern pharmacotherapy has decreased the mortality in the existing population, it has failed to stem the rise. Furthermore, a large segment of the world population cannot afford expensive pharmacotherapy. Therefore, there is an urgent need for inexpensive preventive measures to control the rise in CVD and diabetes and associated co-morbidities. The purpose of this review is to explore the role of food bioactives in prevention of NCDs. To this end, we have critically analyzed the possible utility of three classes of food bioactives: (a) resistant starch, a metabolically resistant carbohydrate known to favorably modulate insulin secretion and glucose metabolism; (b) cyclo (His-Pro), a food-derived cyclic dipeptides; and (c) polyphenol-rich berries. Finally, we have also briefly outlined the strategies needed to prepare these food-bioactives for human use.

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  • Authors+Show Affiliations

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    Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. cprasad@twu.edu. Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70112, USA. cprasad@twu.edu.

    ,

    Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. Vimrhan@twu.edu.

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    Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. sjuma@twu.edu.

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    Department of Nutrition and Food Sciences, Texas Woman's University, Houston, TX 77030, USA. Mmaziarz@twu.edu.

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    Department of Medicine, Division of Cardiology, UT Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. Prasada@uthscsa.edu.

    ,

    Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. CTiernan@twu.edu.

    Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. pvijayagopal@twu.edu.

    Source

    Metabolites 5:4 2015 Dec 12 pg 733-65

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    26703752

    Citation

    Prasad, Chandan, et al. "Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities Beyond the Horizon." Metabolites, vol. 5, no. 4, 2015, pp. 733-65.
    Prasad C, Imrhan V, Juma S, et al. Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon. Metabolites. 2015;5(4):733-65.
    Prasad, C., Imrhan, V., Juma, S., Maziarz, M., Prasad, A., Tiernan, C., & Vijayagopal, P. (2015). Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon. Metabolites, 5(4), pp. 733-65. doi:10.3390/metabo5040733.
    Prasad C, et al. Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities Beyond the Horizon. Metabolites. 2015 Dec 12;5(4):733-65. PubMed PMID: 26703752.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon. AU - Prasad,Chandan, AU - Imrhan,Victorine, AU - Juma,Shanil, AU - Maziarz,Mindy, AU - Prasad,Anand, AU - Tiernan,Casey, AU - Vijayagopal,Parakat, Y1 - 2015/12/12/ PY - 2015/10/08/received PY - 2015/12/02/revised PY - 2015/12/09/accepted PY - 2015/12/26/entrez PY - 2015/12/26/pubmed PY - 2015/12/26/medline KW - cardiovascular disease KW - cyclo (His-Pro) KW - diabetes KW - food bioactives KW - functional food KW - polyphenols KW - resistant starch SP - 733 EP - 65 JF - Metabolites JO - Metabolites VL - 5 IS - 4 N2 - There has been an unprecedented worldwide rise in non-communicable metabolic diseases (NCDs), particularly cardiovascular diseases (CVD) and diabetes. While modern pharmacotherapy has decreased the mortality in the existing population, it has failed to stem the rise. Furthermore, a large segment of the world population cannot afford expensive pharmacotherapy. Therefore, there is an urgent need for inexpensive preventive measures to control the rise in CVD and diabetes and associated co-morbidities. The purpose of this review is to explore the role of food bioactives in prevention of NCDs. To this end, we have critically analyzed the possible utility of three classes of food bioactives: (a) resistant starch, a metabolically resistant carbohydrate known to favorably modulate insulin secretion and glucose metabolism; (b) cyclo (His-Pro), a food-derived cyclic dipeptides; and (c) polyphenol-rich berries. Finally, we have also briefly outlined the strategies needed to prepare these food-bioactives for human use. SN - 2218-1989 UR - https://www.unboundmedicine.com/medline/citation/26703752/full_citation L2 - http://www.mdpi.com/resolver?pii=metabo5040733 DB - PRIME DP - Unbound Medicine ER -