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Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.
Sci Rep 2016; 6:19213SR

Abstract

The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer risk (pooled OR = 0.78; 95%CI: 0.73-0.83). The results of linear and nonlinear dose-response analysis indicated that high serum/plasma selenium and toenail selenium had the efficacy on cancer prevention. However, we did not find a protective efficacy of selenium supplement. High selenium exposure may have different effects on specific types of cancer. It decreased the risk of breast cancer, lung cancer, esophageal cancer, gastric cancer, and prostate cancer, but it was not associated with colorectal cancer, bladder cancer, and skin cancer.

Authors+Show Affiliations

Institute of Environmental Medicine, Zhejiang University, P.R.China. Ningbo Medical Treatment Center Lihuili Hospital, P.R.China.Department of Clinic Medicine, Zhejiang University, Hangzhou, P.R.China.Department of Epidemiology &Biostatistics, Zhejiang University, Hangzhou, P.R.China.Department of Epidemiology &Biostatistics, Zhejiang University, Hangzhou, P.R.China.Department of Epidemiology &Biostatistics, Zhejiang University, Hangzhou, P.R.China.Department of Clinic Medicine, Zhejiang University, Hangzhou, P.R.China.Department of Clinic Medicine, Zhejiang University, Hangzhou, P.R.China.Institute of Environmental Medicine, Zhejiang University, P.R.China. Department of Epidemiology &Biostatistics, Zhejiang University, Hangzhou, P.R.China.Department of Toxicology &Nutrition, Zhejiang University, Hangzhou, P.R.China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26786590

Citation

Cai, Xianlei, et al. "Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression." Scientific Reports, vol. 6, 2016, p. 19213.
Cai X, Wang C, Yu W, et al. Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression. Sci Rep. 2016;6:19213.
Cai, X., Wang, C., Yu, W., Fan, W., Wang, S., Shen, N., ... Wang, F. (2016). Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression. Scientific Reports, 6, p. 19213. doi:10.1038/srep19213.
Cai X, et al. Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression. Sci Rep. 2016 Jan 20;6:19213. PubMed PMID: 26786590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression. AU - Cai,Xianlei, AU - Wang,Chen, AU - Yu,Wanqi, AU - Fan,Wenjie, AU - Wang,Shan, AU - Shen,Ning, AU - Wu,Pengcheng, AU - Li,Xiuyang, AU - Wang,Fudi, Y1 - 2016/01/20/ PY - 2015/10/01/received PY - 2015/12/08/accepted PY - 2016/1/21/entrez PY - 2016/1/21/pubmed PY - 2016/12/27/medline SP - 19213 EP - 19213 JF - Scientific reports JO - Sci Rep VL - 6 N2 - The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer risk (pooled OR = 0.78; 95%CI: 0.73-0.83). The results of linear and nonlinear dose-response analysis indicated that high serum/plasma selenium and toenail selenium had the efficacy on cancer prevention. However, we did not find a protective efficacy of selenium supplement. High selenium exposure may have different effects on specific types of cancer. It decreased the risk of breast cancer, lung cancer, esophageal cancer, gastric cancer, and prostate cancer, but it was not associated with colorectal cancer, bladder cancer, and skin cancer. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/26786590/full_citation L2 - http://dx.doi.org/10.1038/srep19213 DB - PRIME DP - Unbound Medicine ER -