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Does Long-Term Furosemide Therapy Cause Thiamine Deficiency in Patients with Heart Failure? A Focused Review.
Am J Med. 2016 07; 129(7):753.e7-753.e11.AJ

Abstract

Diuretic therapy is a cornerstone in the management of heart failure. Most studies assessing body thiamine status have reported variable degrees of thiamine deficiency in patients with heart failure, particularly those treated chronically with high doses of furosemide. Thiamine deficiency in patients with heart failure seems predominantly to be due to increased urine volume and urinary flow rate. There is also evidence that furosemide may directly inhibit thiamine uptake at the cellular level. Limited data suggest that thiamine supplementation is capable of increasing left ventricular ejection fraction and improving functional capacity in patients with heart failure and a reduced left ventricular ejection fraction who were treated with diuretics (predominantly furosemide). Therefore, it may be reasonable to provide such patients with thiamine supplementation during heart failure exacerbations.

Authors+Show Affiliations

Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia.Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia.Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia. Electronic address: alpertm@health.missouri.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26899752

Citation

Katta, Natraj, et al. "Does Long-Term Furosemide Therapy Cause Thiamine Deficiency in Patients With Heart Failure? a Focused Review." The American Journal of Medicine, vol. 129, no. 7, 2016, pp. 753.e7-753.e11.
Katta N, Balla S, Alpert MA. Does Long-Term Furosemide Therapy Cause Thiamine Deficiency in Patients with Heart Failure? A Focused Review. Am J Med. 2016;129(7):753.e7-753.e11.
Katta, N., Balla, S., & Alpert, M. A. (2016). Does Long-Term Furosemide Therapy Cause Thiamine Deficiency in Patients with Heart Failure? A Focused Review. The American Journal of Medicine, 129(7), e7-e11. https://doi.org/10.1016/j.amjmed.2016.01.037
Katta N, Balla S, Alpert MA. Does Long-Term Furosemide Therapy Cause Thiamine Deficiency in Patients With Heart Failure? a Focused Review. Am J Med. 2016;129(7):753.e7-753.e11. PubMed PMID: 26899752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does Long-Term Furosemide Therapy Cause Thiamine Deficiency in Patients with Heart Failure? A Focused Review. AU - Katta,Natraj, AU - Balla,Sudarshan, AU - Alpert,Martin A, Y1 - 2016/02/18/ PY - 2016/01/09/received PY - 2016/01/19/revised PY - 2016/01/20/accepted PY - 2016/2/23/entrez PY - 2016/2/24/pubmed PY - 2017/5/26/medline KW - Furosemide KW - Heart failure KW - Thiamine KW - Thiamine deficiency SP - 753.e7 EP - 753.e11 JF - The American journal of medicine JO - Am J Med VL - 129 IS - 7 N2 - Diuretic therapy is a cornerstone in the management of heart failure. Most studies assessing body thiamine status have reported variable degrees of thiamine deficiency in patients with heart failure, particularly those treated chronically with high doses of furosemide. Thiamine deficiency in patients with heart failure seems predominantly to be due to increased urine volume and urinary flow rate. There is also evidence that furosemide may directly inhibit thiamine uptake at the cellular level. Limited data suggest that thiamine supplementation is capable of increasing left ventricular ejection fraction and improving functional capacity in patients with heart failure and a reduced left ventricular ejection fraction who were treated with diuretics (predominantly furosemide). Therefore, it may be reasonable to provide such patients with thiamine supplementation during heart failure exacerbations. SN - 1555-7162 UR - https://www.unboundmedicine.com/medline/citation/26899752/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(16)30171-1 DB - PRIME DP - Unbound Medicine ER -