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Whole Grain Intake Reduces Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies.

Abstract

Mounting evidence from epidemiology studies suggests that whole grain intake may reduce pancreatic cancer risk, but convincing evidence is scarce. We conducted a meta-analysis to assess the association between whole grain intake and pancreatic cancer risk. Relevant observational studies were identified by searching PubMed, Embase, Scopus, and Cochrane library databases for the period from January 1980 to July 2015, with no restrictions. We calculated the summary odds ratios (ORs) for pancreatic cancer using random-effects model meta-analysis. Between-study heterogeneity was analyzed using the I statistic. A total of 8 studies regarding whole grain intake were included in the meta-analysis. The pooled OR of pancreatic cancer for those with high versus low whole grain intake was 0.76 (95% confidence interval [CI], 0.64-0.91; P = 0.002). There was no significant heterogeneity across these studies (I² = 11.7%; Pheterogeneity = 0.339). In the subgroup analysis by geographic area, the summary ORs of developing pancreatic cancer were 0.64 (95% CI, 0.53-0.79; P < 0.001; I ²= 0%; Pheterogeneity = 0.482) in the United States (n = 4) and 0.95 (95% CI, 0.63-1.43; P = 0.803; I ²= 45.6%; Pheterogeneity = 0.175) in Europe (n = 2). In the subgroup analysis by type of whole grain, the summary ORs were 0.72 (95% CI, 0.60-0.87; P = .001; I² = 0; Pheterogeneity = 0.876) for grains (n = 4) and 0.74 (95% CI, 0.27-2.02; P = 0.554; I² = 86.3%; Pheterogeneity = 0.007) for wheat (n = 2). A high intake of whole grains was associated with a reduced risk of pancreatic cancer. Because of the absent of more cohort studies, further prospective studies need to be conducted to ensure conclusions that are more robust.

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    From the Research Institute of General Surgery (QL, XW, XG, LZ, NL, JL), Jinling Hospital, Clinical College of Southern Medical University, Nanjing; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province (HZ), Guangdong Medical University, Dongguan; Department of General Surgery (JB, TJ, FT, CW), Jinling Hospital, Medical School of Nanjing University, Nanjing; and Department of Ophthalmology (MX), The Fist Affiliated Hospital of Nanjing Medical University, Nanjing, China.

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    Source

    Medicine 95:9 2016 Mar pg e2747

    MeSH

    Dietary Fiber
    Humans
    Observational Studies as Topic
    Pancreatic Neoplasms
    Protective Factors
    Whole Grains

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26945361

    Citation

    Lei, Qiucheng, et al. "Whole Grain Intake Reduces Pancreatic Cancer Risk: a Meta-Analysis of Observational Studies." Medicine, vol. 95, no. 9, 2016, pp. e2747.
    Lei Q, Zheng H, Bi J, et al. Whole Grain Intake Reduces Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies. Medicine (Baltimore). 2016;95(9):e2747.
    Lei, Q., Zheng, H., Bi, J., Wang, X., Jiang, T., Gao, X., ... Li, J. (2016). Whole Grain Intake Reduces Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies. Medicine, 95(9), pp. e2747. doi:10.1097/MD.0000000000002747.
    Lei Q, et al. Whole Grain Intake Reduces Pancreatic Cancer Risk: a Meta-Analysis of Observational Studies. Medicine (Baltimore). 2016;95(9):e2747. PubMed PMID: 26945361.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Whole Grain Intake Reduces Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies. AU - Lei,Qiucheng, AU - Zheng,Huazhen, AU - Bi,Jingcheng, AU - Wang,Xinying, AU - Jiang,Tingting, AU - Gao,Xuejin, AU - Tian,Feng, AU - Xu,Min, AU - Wu,Chao, AU - Zhang,Li, AU - Li,Ning, AU - Li,Jieshou, PY - 2016/3/6/entrez PY - 2016/3/6/pubmed PY - 2016/7/14/medline SP - e2747 EP - e2747 JF - Medicine JO - Medicine (Baltimore) VL - 95 IS - 9 N2 - Mounting evidence from epidemiology studies suggests that whole grain intake may reduce pancreatic cancer risk, but convincing evidence is scarce. We conducted a meta-analysis to assess the association between whole grain intake and pancreatic cancer risk. Relevant observational studies were identified by searching PubMed, Embase, Scopus, and Cochrane library databases for the period from January 1980 to July 2015, with no restrictions. We calculated the summary odds ratios (ORs) for pancreatic cancer using random-effects model meta-analysis. Between-study heterogeneity was analyzed using the I statistic. A total of 8 studies regarding whole grain intake were included in the meta-analysis. The pooled OR of pancreatic cancer for those with high versus low whole grain intake was 0.76 (95% confidence interval [CI], 0.64-0.91; P = 0.002). There was no significant heterogeneity across these studies (I² = 11.7%; Pheterogeneity = 0.339). In the subgroup analysis by geographic area, the summary ORs of developing pancreatic cancer were 0.64 (95% CI, 0.53-0.79; P < 0.001; I ²= 0%; Pheterogeneity = 0.482) in the United States (n = 4) and 0.95 (95% CI, 0.63-1.43; P = 0.803; I ²= 45.6%; Pheterogeneity = 0.175) in Europe (n = 2). In the subgroup analysis by type of whole grain, the summary ORs were 0.72 (95% CI, 0.60-0.87; P = .001; I² = 0; Pheterogeneity = 0.876) for grains (n = 4) and 0.74 (95% CI, 0.27-2.02; P = 0.554; I² = 86.3%; Pheterogeneity = 0.007) for wheat (n = 2). A high intake of whole grains was associated with a reduced risk of pancreatic cancer. Because of the absent of more cohort studies, further prospective studies need to be conducted to ensure conclusions that are more robust. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/26945361/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=26945361 DB - PRIME DP - Unbound Medicine ER -