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A U-shaped relationship between alcohol consumption and cardiometabolic index in middle-aged men.
Lipids Health Dis 2016; 15:50LH

Abstract

BACKGROUND

Cardiometabolic index (CMI) is a new index for discriminating diabetes. The purpose of this study was to determine whether CMI is affected by habitual alcohol drinking.

METHODS

The subjects were 21572 men (35-60 years) receiving annual health checkups. They were divided by average daily ethanol consumption into non-, light (< 22 g), moderate (≥ 22 and < 44 g), heavy (≥ 44 and < 66 g) and very heavy (≥ 66 g) drinkers. Relationship between alcohol intake and CMI was investigated with adjustment for age and histories of smoking and regular exercise.

RESULTS

Log-transformed CMI was significantly lower in light, moderate and heavy drinkers than in nondrinkers and was lowest in light drinkers, while there was no significant difference in log-transformed CMI of nondrinkers and very heavy drinkers. Odds ratio vs. nondrinkers for high CMI was significantly lower than the reference level of 1.00 in light, moderate and heavy drinkers and was lowest in light drinkers but was not significantly different from the reference level in very heavy drinkers. Odds ratio of subjects with vs. those without high CMI for hyperglycemia was significantly higher than the reference level in all of the alcohol groups and was significantly lower in moderate drinkers but was not significantly different in the other drinker groups when compared with the nondrinker group.

CONCLUSION

There is a U-shaped relationship between alcohol consumption and CMI, and moderate drinking but not excessive drinking attenuates the association between CMI and hyperglycemia.

Authors+Show Affiliations

Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo, 663-8501, Japan. wakabaya@hyo-med.ac.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26956993

Citation

Wakabayashi, Ichiro. "A U-shaped Relationship Between Alcohol Consumption and Cardiometabolic Index in Middle-aged Men." Lipids in Health and Disease, vol. 15, 2016, p. 50.
Wakabayashi I. A U-shaped relationship between alcohol consumption and cardiometabolic index in middle-aged men. Lipids Health Dis. 2016;15:50.
Wakabayashi, I. (2016). A U-shaped relationship between alcohol consumption and cardiometabolic index in middle-aged men. Lipids in Health and Disease, 15, p. 50. doi:10.1186/s12944-016-0217-4.
Wakabayashi I. A U-shaped Relationship Between Alcohol Consumption and Cardiometabolic Index in Middle-aged Men. Lipids Health Dis. 2016 Mar 9;15:50. PubMed PMID: 26956993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A U-shaped relationship between alcohol consumption and cardiometabolic index in middle-aged men. A1 - Wakabayashi,Ichiro, Y1 - 2016/03/09/ PY - 2015/12/15/received PY - 2016/03/01/accepted PY - 2016/3/10/entrez PY - 2016/3/10/pubmed PY - 2016/12/15/medline SP - 50 EP - 50 JF - Lipids in health and disease JO - Lipids Health Dis VL - 15 N2 - BACKGROUND: Cardiometabolic index (CMI) is a new index for discriminating diabetes. The purpose of this study was to determine whether CMI is affected by habitual alcohol drinking. METHODS: The subjects were 21572 men (35-60 years) receiving annual health checkups. They were divided by average daily ethanol consumption into non-, light (< 22 g), moderate (≥ 22 and < 44 g), heavy (≥ 44 and < 66 g) and very heavy (≥ 66 g) drinkers. Relationship between alcohol intake and CMI was investigated with adjustment for age and histories of smoking and regular exercise. RESULTS: Log-transformed CMI was significantly lower in light, moderate and heavy drinkers than in nondrinkers and was lowest in light drinkers, while there was no significant difference in log-transformed CMI of nondrinkers and very heavy drinkers. Odds ratio vs. nondrinkers for high CMI was significantly lower than the reference level of 1.00 in light, moderate and heavy drinkers and was lowest in light drinkers but was not significantly different from the reference level in very heavy drinkers. Odds ratio of subjects with vs. those without high CMI for hyperglycemia was significantly higher than the reference level in all of the alcohol groups and was significantly lower in moderate drinkers but was not significantly different in the other drinker groups when compared with the nondrinker group. CONCLUSION: There is a U-shaped relationship between alcohol consumption and CMI, and moderate drinking but not excessive drinking attenuates the association between CMI and hyperglycemia. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/26956993/full_citation L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-016-0217-4 DB - PRIME DP - Unbound Medicine ER -