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Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: The CHANCES Project.
J Bone Miner Res 2016; 31(9):1743-52JB

Abstract

The role of fruit and vegetable intake in relation to fracture prevention during adulthood and beyond is not adequately understood. We investigated the potential association between fruit and vegetable intake and hip fracture incidence in a large sample of older adults from Europe and the United States. A total of 142,018 individuals (116,509 women) aged ≥60 years, from five cohorts, were followed up prospectively for 1,911,482 person-years, accumulating 5552 hip fractures. Fruit and vegetable intake was assessed by validated, cohort-specific, food-frequency questionnaires (FFQ). Ηip fractures were ascertained through national patient registers or telephone interviews/questionnaires. Adjusted hazard ratios (HRs) derived by Cox proportional hazards regression were estimated for each cohort and subsequently pooled using random effects meta-analysis. Intake of ≤1 serving/day of fruit and vegetables combined was associated with 39% higher hip fracture risk (pooled adjusted HR, 1.39; 95% confidence interval [CI], 1.20 to 1.58) in comparison with moderate intake (>3 and ≤5 servings/day) (pfor heterogeneity = 0.505), whereas higher intakes (>5 servings/day) were not associated with lower risk in comparison with the same reference. Associations were more evident among women. We concluded that a daily intake of 1 or <1 servings of fruits and vegetables was associated with increased hip fracture risk in relation to moderate daily intakes. Older adults with such low fruit and vegetable consumption may benefit from raising their intakes to moderate amounts in order to reduce their hip fracture risk. © 2016 American Society for Bone and Mineral Research.

Authors+Show Affiliations

Department of Hygiene, Epidemiology, and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Hellenic Health Foundation, Athens, Greece.Department of Hygiene, Epidemiology, and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Hellenic Health Foundation, Athens, Greece.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.Department of Surgical Sciences, Section of Orthopedics, Uppsala University, Uppsala, Sweden.Department of Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.Department of Community Medicine, Umeå University, Umeå, Sweden.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institute, Stockholm, Sweden.Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institute, Stockholm, Sweden.Department of Health and Care Sciences, Faculty of Health Sciences, UiT-the Arctic University of Norway, Tromsø, Norway. Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.Institute for Translational Epidemiology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.Department of Hygiene, Epidemiology, and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Hellenic Health Foundation, Athens, Greece.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27061845

Citation

Benetou, Vassiliki, et al. "Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: the CHANCES Project." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 31, no. 9, 2016, pp. 1743-52.
Benetou V, Orfanos P, Feskanich D, et al. Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: The CHANCES Project. J Bone Miner Res. 2016;31(9):1743-52.
Benetou, V., Orfanos, P., Feskanich, D., Michaëlsson, K., Pettersson-Kymmer, U., Eriksson, S., ... Trichopoulou, A. (2016). Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: The CHANCES Project. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 31(9), pp. 1743-52. doi:10.1002/jbmr.2850.
Benetou V, et al. Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: the CHANCES Project. J Bone Miner Res. 2016;31(9):1743-52. PubMed PMID: 27061845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: The CHANCES Project. AU - Benetou,Vassiliki, AU - Orfanos,Philippos, AU - Feskanich,Diane, AU - Michaëlsson,Karl, AU - Pettersson-Kymmer,Ulrika, AU - Eriksson,Sture, AU - Grodstein,Francine, AU - Wolk,Alicja, AU - Bellavia,Andrea, AU - Ahmed,Luai A, AU - Boffeta,Paolo, AU - Trichopoulou,Antonia, Y1 - 2016/06/08/ PY - 2016/02/09/received PY - 2016/03/22/revised PY - 2016/04/07/accepted PY - 2016/4/11/entrez PY - 2016/4/12/pubmed PY - 2017/12/19/medline KW - EPIDEMIOLOGY KW - FRUITS KW - HIP FRACTURE KW - NUTRITION KW - VEGETABLES SP - 1743 EP - 52 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 31 IS - 9 N2 - The role of fruit and vegetable intake in relation to fracture prevention during adulthood and beyond is not adequately understood. We investigated the potential association between fruit and vegetable intake and hip fracture incidence in a large sample of older adults from Europe and the United States. A total of 142,018 individuals (116,509 women) aged ≥60 years, from five cohorts, were followed up prospectively for 1,911,482 person-years, accumulating 5552 hip fractures. Fruit and vegetable intake was assessed by validated, cohort-specific, food-frequency questionnaires (FFQ). Ηip fractures were ascertained through national patient registers or telephone interviews/questionnaires. Adjusted hazard ratios (HRs) derived by Cox proportional hazards regression were estimated for each cohort and subsequently pooled using random effects meta-analysis. Intake of ≤1 serving/day of fruit and vegetables combined was associated with 39% higher hip fracture risk (pooled adjusted HR, 1.39; 95% confidence interval [CI], 1.20 to 1.58) in comparison with moderate intake (>3 and ≤5 servings/day) (pfor heterogeneity = 0.505), whereas higher intakes (>5 servings/day) were not associated with lower risk in comparison with the same reference. Associations were more evident among women. We concluded that a daily intake of 1 or <1 servings of fruits and vegetables was associated with increased hip fracture risk in relation to moderate daily intakes. Older adults with such low fruit and vegetable consumption may benefit from raising their intakes to moderate amounts in order to reduce their hip fracture risk. © 2016 American Society for Bone and Mineral Research. SN - 1523-4681 UR - https://www.unboundmedicine.com/medline/citation/27061845/full_citation L2 - https://doi.org/10.1002/jbmr.2850 DB - PRIME DP - Unbound Medicine ER -