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Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics.

Abstract

Dietary supplements (DS) are extensively consumed worldwide despite unproven efficacy. The true incidence of DS-induced liver injury (DSILI) is unknown but is probably under-diagnosed due to the general belief of safety of these products. Reported cases of herbals and DS-induced liver injury are increasing worldwide. The aim of this manuscript is to report a tabular listing with a description of DS associated with hepatotoxicity as well as review the phenotype and severity of DSILI. Natural remedies related to hepatotoxicity can be divided into herbal product-induced liver injury and DS-induced liver injury. In this article, we describe different DS associated with liver injury, some of them manufactured DS containing several ingredients (Herbalife™ products, Hydroxycut™, LipoKinetix™, UCP-1 and OxyELITE™) while others have a single ingredient (green tea extract, linoleic acid, usnic acid, 1,3-Dimethylamylamine, vitamin A, Garcinia cambogia and ma huang). Additional DS containing some of the aforementioned ingredients implicated in liver injury are also covered. We have also included illicit androgenic anabolic steroids for bodybuilding in this work, as they are frequently sold under the denomination of DS despite being conventional drugs.

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  • Authors+Show Affiliations

    ,

    Servicio de Farmacología Clíınica and Unidad de Gestión Clínica (UGC) de Gastroenterología y Hepatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), 29010 Málaga, Spain. mirengar1@hotmail.com. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain. mirengar1@hotmail.com.

    ,

    Servicio de Farmacología Clíınica and Unidad de Gestión Clínica (UGC) de Gastroenterología y Hepatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), 29010 Málaga, Spain. mrobles@uma.es. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain. mrobles@uma.es.

    ,

    Servicio de Farmacología Clíınica and Unidad de Gestión Clínica (UGC) de Gastroenterología y Hepatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), 29010 Málaga, Spain. aida_ortega_alonso@hotmail.com.

    ,

    Servicio de Farmacología Clíınica and Unidad de Gestión Clínica (UGC) de Gastroenterología y Hepatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), 29010 Málaga, Spain. imcaliz@uma.es.

    Servicio de Farmacología Clíınica and Unidad de Gestión Clínica (UGC) de Gastroenterología y Hepatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), 29010 Málaga, Spain. andrade@uma.es. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain. andrade@uma.es.

    Source

    MeSH

    Chemical and Drug Induced Liver Injury
    Clinical Trials as Topic
    Dietary Supplements
    Female
    Humans
    Male
    Plant Preparations
    Plants, Medicinal
    Testosterone Congeners

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    27070596

    Citation

    García-Cortés, Miren, et al. "Hepatotoxicity By Dietary Supplements: a Tabular Listing and Clinical Characteristics." International Journal of Molecular Sciences, vol. 17, no. 4, 2016, p. 537.
    García-Cortés M, Robles-Díaz M, Ortega-Alonso A, et al. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. Int J Mol Sci. 2016;17(4):537.
    García-Cortés, M., Robles-Díaz, M., Ortega-Alonso, A., Medina-Caliz, I., & Andrade, R. J. (2016). Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. International Journal of Molecular Sciences, 17(4), p. 537. doi:10.3390/ijms17040537.
    García-Cortés M, et al. Hepatotoxicity By Dietary Supplements: a Tabular Listing and Clinical Characteristics. Int J Mol Sci. 2016 Apr 9;17(4):537. PubMed PMID: 27070596.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. AU - García-Cortés,Miren, AU - Robles-Díaz,Mercedes, AU - Ortega-Alonso,Aida, AU - Medina-Caliz,Inmaculada, AU - Andrade,Raul J, Y1 - 2016/04/09/ PY - 2016/02/22/received PY - 2016/03/17/revised PY - 2016/03/25/accepted PY - 2016/4/13/entrez PY - 2016/4/14/pubmed PY - 2016/12/17/medline KW - Herbalife products KW - Hydroxycut KW - Oxyelite Pro KW - anabolic steroids KW - dietary supplements KW - green tea KW - hepatotoxicity KW - liver injury KW - usnic acid KW - vitamin A SP - 537 EP - 537 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 17 IS - 4 N2 - Dietary supplements (DS) are extensively consumed worldwide despite unproven efficacy. The true incidence of DS-induced liver injury (DSILI) is unknown but is probably under-diagnosed due to the general belief of safety of these products. Reported cases of herbals and DS-induced liver injury are increasing worldwide. The aim of this manuscript is to report a tabular listing with a description of DS associated with hepatotoxicity as well as review the phenotype and severity of DSILI. Natural remedies related to hepatotoxicity can be divided into herbal product-induced liver injury and DS-induced liver injury. In this article, we describe different DS associated with liver injury, some of them manufactured DS containing several ingredients (Herbalife™ products, Hydroxycut™, LipoKinetix™, UCP-1 and OxyELITE™) while others have a single ingredient (green tea extract, linoleic acid, usnic acid, 1,3-Dimethylamylamine, vitamin A, Garcinia cambogia and ma huang). Additional DS containing some of the aforementioned ingredients implicated in liver injury are also covered. We have also included illicit androgenic anabolic steroids for bodybuilding in this work, as they are frequently sold under the denomination of DS despite being conventional drugs. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/27070596/full_citation L2 - http://www.mdpi.com/resolver?pii=ijms17040537 DB - PRIME DP - Unbound Medicine ER -