TY - JOUR T1 - Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes. AU - Chen,Rong, AU - Ovbiagele,Bruce, AU - Feng,Wuwei, PY - 2015/10/09/received PY - 2016/01/25/revised PY - 2016/01/25/accepted PY - 2016/4/16/entrez PY - 2016/4/16/pubmed PY - 2016/9/13/medline KW - Diabetes KW - Hyperglycemia KW - Outcomes KW - Stroke KW - Stroke prevention SP - 380 EP - 6 JF - The American journal of the medical sciences JO - Am J Med Sci VL - 351 IS - 4 N2 - There has been a significant increase in obesity rates worldwide with the corresponding surge in diabetes. Diabetes causes various microvascular and macrovascular changes often culminating in major clinical complications, 1 of which, is stroke. Although gains have been made over the last 2 decades in reducing the burden of stroke, the recent rise in rates of diabetes threatens to reverse these advances. Of the several mechanistic stroke subtypes, individuals with diabetes are especially susceptible to the consequences of cerebral small vessel diseases. Hyperglycemia confers greater risk of stroke occurrence. This increased risk is often seen in individuals with diabetes and is associated with poorer clinical outcomes (including higher mortality), especially following ischemic stroke. Improving stroke outcomes in individuals with diabetes requires prompt and persistent implementation of evidence-based medical therapies as well as adoption of beneficial lifestyle practices. SN - 1538-2990 UR - https://www.unboundmedicine.com/medline/citation/27079344/full_citation DB - PRIME DP - Unbound Medicine ER -