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Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer.
Am J Clin Nutr 1989; 49(5):895-900AJ

Abstract

In a nested case-control study the stored, frozen sera from 22 cases of cancer of the pancreas and 44 matched control subjects were assayed for retinol, retinol-binding protein, total carotenoids, beta-carotene, lycopene, vitamin E (alpha-tocopherol), and selenium. Prediagnostic serum levels of lycopene and Se were lower among cases than among matched control subjects. These differences remained after adjustment was made for possible confounding by smoking, educational level, and the other measured serum levels. Low levels of serum vitamin E appeared to have a protective effect but a chance association between vitamin E and cancer of the pancreas could not reasonably be excluded. The association between cancer of the pancreas and serum Se was significant when the data were analyzed as a whole but its effect was seen principally in men.

Authors+Show Affiliations

Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2718925

Citation

Burney, P G., et al. "Serologic Precursors of Cancer: Serum Micronutrients and the Subsequent Risk of Pancreatic Cancer." The American Journal of Clinical Nutrition, vol. 49, no. 5, 1989, pp. 895-900.
Burney PG, Comstock GW, Morris JS. Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer. Am J Clin Nutr. 1989;49(5):895-900.
Burney, P. G., Comstock, G. W., & Morris, J. S. (1989). Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer. The American Journal of Clinical Nutrition, 49(5), pp. 895-900.
Burney PG, Comstock GW, Morris JS. Serologic Precursors of Cancer: Serum Micronutrients and the Subsequent Risk of Pancreatic Cancer. Am J Clin Nutr. 1989;49(5):895-900. PubMed PMID: 2718925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer. AU - Burney,P G, AU - Comstock,G W, AU - Morris,J S, PY - 1989/5/1/pubmed PY - 1989/5/1/medline PY - 1989/5/1/entrez SP - 895 EP - 900 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 49 IS - 5 N2 - In a nested case-control study the stored, frozen sera from 22 cases of cancer of the pancreas and 44 matched control subjects were assayed for retinol, retinol-binding protein, total carotenoids, beta-carotene, lycopene, vitamin E (alpha-tocopherol), and selenium. Prediagnostic serum levels of lycopene and Se were lower among cases than among matched control subjects. These differences remained after adjustment was made for possible confounding by smoking, educational level, and the other measured serum levels. Low levels of serum vitamin E appeared to have a protective effect but a chance association between vitamin E and cancer of the pancreas could not reasonably be excluded. The association between cancer of the pancreas and serum Se was significant when the data were analyzed as a whole but its effect was seen principally in men. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/2718925/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/49.5.895 DB - PRIME DP - Unbound Medicine ER -