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Attention-deficit/hyperactivity disorder-related symptoms improved with allergic rhinitis treatment in children.

Abstract

BACKGROUND

Increased prevalence of attention-deficit/hyperactivity disorder (ADHD) in children with allergic rhinitis (AR) has been reported. Our previous study showed that children with untreated AR had higher ADHD scores than did the controls.

OBJECTIVE

This prospective follow-up study aimed to investigate whether elevated ADHD scores in children with AR could be decreased by AR treatment.

METHODS

Sixty-eight children with AR (age range, 6-14 years) and who were drug naive were enrolled and evaluated by AR symptom score, ADHD symptom scores, and computerized continuous performance test, before and after AR therapy, which included nonpharmacologic intervention, oral antihistamines, and topical steroids. Thirty-one age-matched controls and 13 children with pure ADHD were also enrolled for comparison. The relationship between the AR and ADHD score change was analyzed by a partial correlation test, and univariate and multivariate linear regression models were applied to investigate possible predictors for the improvement of ADHD scores by AR treatment.

RESULTS

AR symptom scores in children with AR decreased significantly after treatment (p < 0.001), and their ADHD scores also decreased significantly (p < 0.001). An improved AR symptom score was positively correlated with improved detectability (rp = 0.617, p = 0.001) and commission error (rp = 0.511, p = 0.011). Significant predictors for the improvement of ADHD scores included age, AR drugs, AR subtypes, and multiple atopic diseases (ps < 0.05).

CONCLUSION

Higher ADHD scores in children with AR compared with healthy controls decreased significantly with AR treatment. For children with AR and borderline ADHD symptoms, who do not meet full ADHD diagnostic criteria, we recommend initially treating their AR and monitoring improvement of ADHD symptoms.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

    , , , ,

    Source

    MeSH

    Administration, Oral
    Administration, Topical
    Adolescent
    Attention Deficit Disorder with Hyperactivity
    Child
    China
    Female
    Follow-Up Studies
    Histamine Antagonists
    Humans
    Male
    Prospective Studies
    Rhinitis, Allergic
    Steroids
    Treatment Outcome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27216352

    Citation

    Yang, Ming-Tao, et al. "Attention-deficit/hyperactivity Disorder-related Symptoms Improved With Allergic Rhinitis Treatment in Children." American Journal of Rhinology & Allergy, vol. 30, no. 3, 2016, pp. 209-14.
    Yang MT, Chen CC, Lee WT, et al. Attention-deficit/hyperactivity disorder-related symptoms improved with allergic rhinitis treatment in children. Am J Rhinol Allergy. 2016;30(3):209-14.
    Yang, M. T., Chen, C. C., Lee, W. T., Liang, J. S., Fu, W. M., & Yang, Y. H. (2016). Attention-deficit/hyperactivity disorder-related symptoms improved with allergic rhinitis treatment in children. American Journal of Rhinology & Allergy, 30(3), pp. 209-14. doi:10.2500/ajra.2016.30.4301.
    Yang MT, et al. Attention-deficit/hyperactivity Disorder-related Symptoms Improved With Allergic Rhinitis Treatment in Children. Am J Rhinol Allergy. 2016;30(3):209-14. PubMed PMID: 27216352.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Attention-deficit/hyperactivity disorder-related symptoms improved with allergic rhinitis treatment in children. AU - Yang,Ming-Tao, AU - Chen,Chia-Chun, AU - Lee,Wang-Tso, AU - Liang,Jao-Shwann, AU - Fu,Wen-Mei, AU - Yang,Yao-Hsu, PY - 2016/5/25/entrez PY - 2016/5/25/pubmed PY - 2017/1/31/medline SP - 209 EP - 14 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 30 IS - 3 N2 - BACKGROUND: Increased prevalence of attention-deficit/hyperactivity disorder (ADHD) in children with allergic rhinitis (AR) has been reported. Our previous study showed that children with untreated AR had higher ADHD scores than did the controls. OBJECTIVE: This prospective follow-up study aimed to investigate whether elevated ADHD scores in children with AR could be decreased by AR treatment. METHODS: Sixty-eight children with AR (age range, 6-14 years) and who were drug naive were enrolled and evaluated by AR symptom score, ADHD symptom scores, and computerized continuous performance test, before and after AR therapy, which included nonpharmacologic intervention, oral antihistamines, and topical steroids. Thirty-one age-matched controls and 13 children with pure ADHD were also enrolled for comparison. The relationship between the AR and ADHD score change was analyzed by a partial correlation test, and univariate and multivariate linear regression models were applied to investigate possible predictors for the improvement of ADHD scores by AR treatment. RESULTS: AR symptom scores in children with AR decreased significantly after treatment (p < 0.001), and their ADHD scores also decreased significantly (p < 0.001). An improved AR symptom score was positively correlated with improved detectability (rp = 0.617, p = 0.001) and commission error (rp = 0.511, p = 0.011). Significant predictors for the improvement of ADHD scores included age, AR drugs, AR subtypes, and multiple atopic diseases (ps < 0.05). CONCLUSION: Higher ADHD scores in children with AR compared with healthy controls decreased significantly with AR treatment. For children with AR and borderline ADHD symptoms, who do not meet full ADHD diagnostic criteria, we recommend initially treating their AR and monitoring improvement of ADHD symptoms. SN - 1945-8932 UR - https://www.unboundmedicine.com/medline/citation/27216352/full_citation L2 - http://journals.sagepub.com/doi/full/10.2500/ajra.2016.30.4301?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -