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Dietary inflammatory index and prostate cancer survival.

Abstract

Systemic inflammatory status has been reported to impact survival of prostate cancer (PCa) patients; however, evidence is lacking on whether the inflammatory potential of diet can influence prognosis of PCa patients. To investigate the association between a dietary inflammatory index (DII) and PCa survival, we conducted a retrospective cohort study including 726 men with PCa originally enrolled, between 1995 and 2002, in an Italian case-control study. Information on diet and Gleason score was collected at PCa diagnosis. DII was derived from a food frequency questionnaire using a validated algorithm. Adjusted hazard ratios (HRs) of death with 95% confidence intervals (CIs) were estimated using a Fine-Gray model. DII scores were not significantly associated with all-cause mortality of PCa patients (HR highest vs. lowest DII tertile = 1.25; 95% CI: 0.86-1.83). However, considerable heterogeneity emerged according to Gleason score (p < 0.01): no associations emerged among men with Gleason score 2-6 PCa; whereas, among patients with Gleason score 7-10 PCa, DII was directly associated with both all-cause and PCa-specific mortality (HR highest vs. lowest DII tertile: 2.78; 95% CI: 1.41-5.48; and 4.01; 95% CI: 1.25-12.86; respectively). Among patients with Gleason score 7-10 PCa, ten-year all-cause survival probabilities were 58% (95% CI: 47-67%) for highest and 78% (95% CI: 67-86%) for lowest DII tertile. Study findings support the hypothesis that diet, through its inflammatory potential, may influence the prognosis of patients with more aggressive PCa. Dietary interventions aimed at decreasing inflammation may be considered to improve survival of men with PCa.

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  • Authors+Show Affiliations

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    Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, Pordenone, Italy.

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    Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, Pordenone, Italy.

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    Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. Connecting Health Innovations LLC, Columbia, SC, USA.

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    Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. Connecting Health Innovations LLC, Columbia, SC, USA.

    ,

    Venetian Cancer Registry, Veneto Region, Padua, Italy.

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    Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, Pordenone, Italy.

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    Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, Pordenone, Italy.

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    Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, Pordenone, Italy.

    Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, Pordenone, Italy. polesel@cro.it.

    Source

    International journal of cancer 139:11 2016 Dec 01 pg 2398-404

    MeSH

    Aged
    Case-Control Studies
    Cohort Studies
    Diet
    Humans
    Inflammation
    Italy
    Male
    Middle Aged
    Neoplasm Grading
    Prostatic Neoplasms
    Retrospective Studies

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    27242333

    Citation

    Zucchetto, Antonella, et al. "Dietary Inflammatory Index and Prostate Cancer Survival." International Journal of Cancer, vol. 139, no. 11, 2016, pp. 2398-404.
    Zucchetto A, Gini A, Shivappa N, et al. Dietary inflammatory index and prostate cancer survival. Int J Cancer. 2016;139(11):2398-404.
    Zucchetto, A., Gini, A., Shivappa, N., Hébert, J. R., Stocco, C., Dal Maso, L., ... Polesel, J. (2016). Dietary inflammatory index and prostate cancer survival. International Journal of Cancer, 139(11), pp. 2398-404. doi:10.1002/ijc.30208.
    Zucchetto A, et al. Dietary Inflammatory Index and Prostate Cancer Survival. Int J Cancer. 2016 Dec 1;139(11):2398-404. PubMed PMID: 27242333.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary inflammatory index and prostate cancer survival. AU - Zucchetto,Antonella, AU - Gini,Andrea, AU - Shivappa,Nitin, AU - Hébert,James R, AU - Stocco,Carmen, AU - Dal Maso,Luigino, AU - Birri,Silvia, AU - Serraino,Diego, AU - Polesel,Jerry, Y1 - 2016/06/11/ PY - 2016/02/12/received PY - 2016/05/06/revised PY - 2016/05/19/accepted PY - 2016/6/1/entrez PY - 2016/6/1/pubmed PY - 2017/5/13/medline KW - diet KW - inflammation KW - inflammatory index KW - prostate cancer KW - survival SP - 2398 EP - 404 JF - International journal of cancer JO - Int. J. Cancer VL - 139 IS - 11 N2 - Systemic inflammatory status has been reported to impact survival of prostate cancer (PCa) patients; however, evidence is lacking on whether the inflammatory potential of diet can influence prognosis of PCa patients. To investigate the association between a dietary inflammatory index (DII) and PCa survival, we conducted a retrospective cohort study including 726 men with PCa originally enrolled, between 1995 and 2002, in an Italian case-control study. Information on diet and Gleason score was collected at PCa diagnosis. DII was derived from a food frequency questionnaire using a validated algorithm. Adjusted hazard ratios (HRs) of death with 95% confidence intervals (CIs) were estimated using a Fine-Gray model. DII scores were not significantly associated with all-cause mortality of PCa patients (HR highest vs. lowest DII tertile = 1.25; 95% CI: 0.86-1.83). However, considerable heterogeneity emerged according to Gleason score (p < 0.01): no associations emerged among men with Gleason score 2-6 PCa; whereas, among patients with Gleason score 7-10 PCa, DII was directly associated with both all-cause and PCa-specific mortality (HR highest vs. lowest DII tertile: 2.78; 95% CI: 1.41-5.48; and 4.01; 95% CI: 1.25-12.86; respectively). Among patients with Gleason score 7-10 PCa, ten-year all-cause survival probabilities were 58% (95% CI: 47-67%) for highest and 78% (95% CI: 67-86%) for lowest DII tertile. Study findings support the hypothesis that diet, through its inflammatory potential, may influence the prognosis of patients with more aggressive PCa. Dietary interventions aimed at decreasing inflammation may be considered to improve survival of men with PCa. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/27242333/full_citation L2 - https://doi.org/10.1002/ijc.30208 DB - PRIME DP - Unbound Medicine ER -