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Environmental risk factors for type 1 diabetes.
Lancet. 2016 Jun 04; 387(10035):2340-2348.Lct

Abstract

The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to β cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.

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Authors+Show Affiliations

Rewers M
Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.
Ludvigsson J
Division of Pediatrics, Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University and Linköping University Hospital, Linköping, Sweden. Electronic address: johnny.ludvigsson@liu.se.

MeSH

AnimalsAutoantigensAutoimmunityBirth WeightBreast FeedingDiabetes Mellitus, Type 1DietEnvironmentFatty Acids, UnsaturatedGrowthHumansHygieneInfantInfant FoodInsulin-Secreting CellsMilkRNARisk FactorsToxins, BiologicalVaccinesVitamin D

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

27302273

Clinical Trial Links

Gene Study for Infantile Onset Diabetes

Citation

Rewers, Marian, and Johnny Ludvigsson. "Environmental Risk Factors for Type 1 Diabetes." Lancet (London, England), vol. 387, no. 10035, 2016, pp. 2340-2348.
Rewers M, Ludvigsson J. Environmental risk factors for type 1 diabetes. Lancet. 2016;387(10035):2340-2348.
Rewers, M., & Ludvigsson, J. (2016). Environmental risk factors for type 1 diabetes. Lancet (London, England), 387(10035), 2340-2348. https://doi.org/10.1016/S0140-6736(16)30507-4
Rewers M, Ludvigsson J. Environmental Risk Factors for Type 1 Diabetes. Lancet. 2016 Jun 4;387(10035):2340-2348. PubMed PMID: 27302273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental risk factors for type 1 diabetes. AU - Rewers,Marian, AU - Ludvigsson,Johnny, PY - 2016/6/16/entrez PY - 2016/6/16/pubmed PY - 2016/6/28/medline SP - 2340 EP - 2348 JF - Lancet (London, England) JO - Lancet VL - 387 IS - 10035 N2 - The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to β cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/27302273/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓338 ↑131]

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