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Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer.

Abstract

Several epidemiological investigations have been conducted to evaluate the relationship between dietary cholesterol intake and risk of breast cancer, but the results are inconsistent. This meta-analysis was performed to summarize the evidence from observational studies to test the hypothesis that dietary cholesterol intake increases the risk of breast cancer. PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure were searched for relevant articles published up to July 2015. Pooled relative risks were calculated with random effects model. Dose-response relationship was assessed by restricted cubic spline model. Overall, 9 articles involving 6 cohort studies and 3 case-control studies were included in this study. The pooled relative risk with 95% confidence intervals of breast cancer for the highest vs lowest category of dietary cholesterol intake was 1.29 (1.06-1.56). For dose-response analysis, a nonlinear relationship was found between dietary cholesterol and breast cancer, and the association became statistically significant when the cholesterol intake was greater than 370 mg/d. Results from this meta-analysis indicated that dietary cholesterol was associated with an increased risk of breast cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, No. 38 Dengzhou Rd, Qingdao, Shandong 266021, People's Republic of China.

    ,

    Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, No. 38 Dengzhou Rd, Qingdao, Shandong 266021, People's Republic of China.

    ,

    Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, No. 38 Dengzhou Rd, Qingdao, Shandong 266021, People's Republic of China.

    Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, No. 38 Dengzhou Rd, Qingdao, Shandong 266021, People's Republic of China. Electronic address: wenjie-jiang@126.com.

    Source

    MeSH

    Breast Neoplasms
    Cholesterol, Dietary
    Female
    Humans
    Observational Studies as Topic
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    27333953

    Citation

    Li, Changkun, et al. "Systematic Review and Meta-analysis Suggest That Dietary Cholesterol Intake Increases Risk of Breast Cancer." Nutrition Research (New York, N.Y.), vol. 36, no. 7, 2016, pp. 627-35.
    Li C, Yang L, Zhang D, et al. Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer. Nutr Res. 2016;36(7):627-35.
    Li, C., Yang, L., Zhang, D., & Jiang, W. (2016). Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer. Nutrition Research (New York, N.Y.), 36(7), pp. 627-35. doi:10.1016/j.nutres.2016.04.009.
    Li C, et al. Systematic Review and Meta-analysis Suggest That Dietary Cholesterol Intake Increases Risk of Breast Cancer. Nutr Res. 2016;36(7):627-35. PubMed PMID: 27333953.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer. AU - Li,Changkun, AU - Yang,Li, AU - Zhang,Dongfeng, AU - Jiang,Wenjie, Y1 - 2016/04/26/ PY - 2015/11/09/received PY - 2016/04/07/revised PY - 2016/04/23/accepted PY - 2016/6/24/entrez PY - 2016/6/24/pubmed PY - 2018/1/19/medline KW - Breast cancer KW - Dietary cholesterol KW - Fat intake KW - Meta-analysis KW - Review SP - 627 EP - 35 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 36 IS - 7 N2 - Several epidemiological investigations have been conducted to evaluate the relationship between dietary cholesterol intake and risk of breast cancer, but the results are inconsistent. This meta-analysis was performed to summarize the evidence from observational studies to test the hypothesis that dietary cholesterol intake increases the risk of breast cancer. PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure were searched for relevant articles published up to July 2015. Pooled relative risks were calculated with random effects model. Dose-response relationship was assessed by restricted cubic spline model. Overall, 9 articles involving 6 cohort studies and 3 case-control studies were included in this study. The pooled relative risk with 95% confidence intervals of breast cancer for the highest vs lowest category of dietary cholesterol intake was 1.29 (1.06-1.56). For dose-response analysis, a nonlinear relationship was found between dietary cholesterol and breast cancer, and the association became statistically significant when the cholesterol intake was greater than 370 mg/d. Results from this meta-analysis indicated that dietary cholesterol was associated with an increased risk of breast cancer. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/27333953/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(16)30026-4 DB - PRIME DP - Unbound Medicine ER -