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Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer.
Nutr Res 2016; 36(7):627-35NR

Abstract

Several epidemiological investigations have been conducted to evaluate the relationship between dietary cholesterol intake and risk of breast cancer, but the results are inconsistent. This meta-analysis was performed to summarize the evidence from observational studies to test the hypothesis that dietary cholesterol intake increases the risk of breast cancer. PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure were searched for relevant articles published up to July 2015. Pooled relative risks were calculated with random effects model. Dose-response relationship was assessed by restricted cubic spline model. Overall, 9 articles involving 6 cohort studies and 3 case-control studies were included in this study. The pooled relative risk with 95% confidence intervals of breast cancer for the highest vs lowest category of dietary cholesterol intake was 1.29 (1.06-1.56). For dose-response analysis, a nonlinear relationship was found between dietary cholesterol and breast cancer, and the association became statistically significant when the cholesterol intake was greater than 370 mg/d. Results from this meta-analysis indicated that dietary cholesterol was associated with an increased risk of breast cancer.

Authors+Show Affiliations

Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, No. 38 Dengzhou Rd, Qingdao, Shandong 266021, People's Republic of China.Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, No. 38 Dengzhou Rd, Qingdao, Shandong 266021, People's Republic of China.Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, No. 38 Dengzhou Rd, Qingdao, Shandong 266021, People's Republic of China.Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, No. 38 Dengzhou Rd, Qingdao, Shandong 266021, People's Republic of China. Electronic address: wenjie-jiang@126.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27333953

Citation

Li, Changkun, et al. "Systematic Review and Meta-analysis Suggest That Dietary Cholesterol Intake Increases Risk of Breast Cancer." Nutrition Research (New York, N.Y.), vol. 36, no. 7, 2016, pp. 627-35.
Li C, Yang L, Zhang D, et al. Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer. Nutr Res. 2016;36(7):627-35.
Li, C., Yang, L., Zhang, D., & Jiang, W. (2016). Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer. Nutrition Research (New York, N.Y.), 36(7), pp. 627-35. doi:10.1016/j.nutres.2016.04.009.
Li C, et al. Systematic Review and Meta-analysis Suggest That Dietary Cholesterol Intake Increases Risk of Breast Cancer. Nutr Res. 2016;36(7):627-35. PubMed PMID: 27333953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer. AU - Li,Changkun, AU - Yang,Li, AU - Zhang,Dongfeng, AU - Jiang,Wenjie, Y1 - 2016/04/26/ PY - 2015/11/09/received PY - 2016/04/07/revised PY - 2016/04/23/accepted PY - 2016/6/24/entrez PY - 2016/6/24/pubmed PY - 2018/1/19/medline KW - Breast cancer KW - Dietary cholesterol KW - Fat intake KW - Meta-analysis KW - Review SP - 627 EP - 35 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 36 IS - 7 N2 - Several epidemiological investigations have been conducted to evaluate the relationship between dietary cholesterol intake and risk of breast cancer, but the results are inconsistent. This meta-analysis was performed to summarize the evidence from observational studies to test the hypothesis that dietary cholesterol intake increases the risk of breast cancer. PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure were searched for relevant articles published up to July 2015. Pooled relative risks were calculated with random effects model. Dose-response relationship was assessed by restricted cubic spline model. Overall, 9 articles involving 6 cohort studies and 3 case-control studies were included in this study. The pooled relative risk with 95% confidence intervals of breast cancer for the highest vs lowest category of dietary cholesterol intake was 1.29 (1.06-1.56). For dose-response analysis, a nonlinear relationship was found between dietary cholesterol and breast cancer, and the association became statistically significant when the cholesterol intake was greater than 370 mg/d. Results from this meta-analysis indicated that dietary cholesterol was associated with an increased risk of breast cancer. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/27333953/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(16)30026-4 DB - PRIME DP - Unbound Medicine ER -