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Body mass index and colorectal cancer prognosis: a systematic review and meta-analysis.
Tech Coloproctol 2016; 20(8):517-35TC

Abstract

Colorectal cancer is one of the most common cancers worldwide. However, it is unclear what influence body mass index (BMI) has on colorectal cancer prognosis. We conducted a systematic review and meta-analysis of observational studies to examine the association of BMI with colorectal cancer outcomes. We searched MEDLINE and EMBASE databases from inception to February 2015 and references of identified articles. We selected observational studies that reported all-cause mortality, colorectal cancer-specific mortality, recurrence and disease-free survival according to BMI category. Random-effects meta-analyses were conducted to combine estimates. We included 18 observational studies. Obese patients had an increased risk of all-cause mortality [relative risk (RR) 1.14; 95 % confidence interval (CI) 1.07-1.21], cancer-specific mortality (RR 1.14; 95 % CI 1.05-1.24), recurrence (RR 1.07; 95 % CI 1.02-1.13) and worse disease-free survival (RR 1.07; 95 % CI 1.01-1.13). Underweight patients also had an increased risk of all-cause mortality (RR 1.43; 95 % CI 1.26-1.62), cancer-specific mortality (RR 1.50; 95 % CI 1.20-1.87), recurrence (RR 1.13; 95 % CI 1.05-1.21) and worse disease-free survival (RR 1.27; 95 % CI 1.13-1.43). Overweight patients had no increased risk for any of the outcomes studied. Both obese and underweight patients with colorectal cancer have an increased risk of all-cause mortality, cancer-specific mortality, disease recurrence and worse disease-free survival compared to normal weight patients.

Authors+Show Affiliations

Department of Surgery and Anaesthesia, University of Nottingham, Derby, UK.Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA.Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA.Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA. gagliarg@yahoo.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27343117

Citation

Doleman, B, et al. "Body Mass Index and Colorectal Cancer Prognosis: a Systematic Review and Meta-analysis." Techniques in Coloproctology, vol. 20, no. 8, 2016, pp. 517-35.
Doleman B, Mills KT, Lim S, et al. Body mass index and colorectal cancer prognosis: a systematic review and meta-analysis. Tech Coloproctol. 2016;20(8):517-35.
Doleman, B., Mills, K. T., Lim, S., Zelhart, M. D., & Gagliardi, G. (2016). Body mass index and colorectal cancer prognosis: a systematic review and meta-analysis. Techniques in Coloproctology, 20(8), pp. 517-35. doi:10.1007/s10151-016-1498-3.
Doleman B, et al. Body Mass Index and Colorectal Cancer Prognosis: a Systematic Review and Meta-analysis. Tech Coloproctol. 2016;20(8):517-35. PubMed PMID: 27343117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index and colorectal cancer prognosis: a systematic review and meta-analysis. AU - Doleman,B, AU - Mills,K T, AU - Lim,S, AU - Zelhart,M D, AU - Gagliardi,G, Y1 - 2016/06/24/ PY - 2016/05/15/received PY - 2016/05/18/accepted PY - 2016/6/26/entrez PY - 2016/6/28/pubmed PY - 2017/9/22/medline KW - BMI KW - Body weight KW - Colorectal cancer KW - Mortality KW - Obesity KW - Systematic review SP - 517 EP - 35 JF - Techniques in coloproctology JO - Tech Coloproctol VL - 20 IS - 8 N2 - Colorectal cancer is one of the most common cancers worldwide. However, it is unclear what influence body mass index (BMI) has on colorectal cancer prognosis. We conducted a systematic review and meta-analysis of observational studies to examine the association of BMI with colorectal cancer outcomes. We searched MEDLINE and EMBASE databases from inception to February 2015 and references of identified articles. We selected observational studies that reported all-cause mortality, colorectal cancer-specific mortality, recurrence and disease-free survival according to BMI category. Random-effects meta-analyses were conducted to combine estimates. We included 18 observational studies. Obese patients had an increased risk of all-cause mortality [relative risk (RR) 1.14; 95 % confidence interval (CI) 1.07-1.21], cancer-specific mortality (RR 1.14; 95 % CI 1.05-1.24), recurrence (RR 1.07; 95 % CI 1.02-1.13) and worse disease-free survival (RR 1.07; 95 % CI 1.01-1.13). Underweight patients also had an increased risk of all-cause mortality (RR 1.43; 95 % CI 1.26-1.62), cancer-specific mortality (RR 1.50; 95 % CI 1.20-1.87), recurrence (RR 1.13; 95 % CI 1.05-1.21) and worse disease-free survival (RR 1.27; 95 % CI 1.13-1.43). Overweight patients had no increased risk for any of the outcomes studied. Both obese and underweight patients with colorectal cancer have an increased risk of all-cause mortality, cancer-specific mortality, disease recurrence and worse disease-free survival compared to normal weight patients. SN - 1128-045X UR - https://www.unboundmedicine.com/medline/citation/27343117/full_citation L2 - https://dx.doi.org/10.1007/s10151-016-1498-3 DB - PRIME DP - Unbound Medicine ER -