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Vitamin D deficiency in patients with liver cirrhosis.

Abstract

There is ongoing evidence that vitamin D is related to the pathophysiology of cirrhosis. Although the incidence of vitamin D deficiency in chronic liver diseases and cirrhosis is strongly documented, its pathogenic association with advanced liver fibrosis remains controversial. There is evidence of a significant relation of 25(OH)D levels with the degree of liver dysfunction, considering that an inverse correlation of 25(OH)D levels with both Child-Pugh score and Model for End-Stage Liver Disease has been reported. In addition, vitamin D deficiency has been shown to increase the risk for overall mortality and infections in patients with cirrhosis. Vitamin D deficiency has been also associated with advanced stages of hepatocellular carcinoma and poor prognosis. Finally, there are studies suggesting that patients with chronic hepatitis C and normal vitamin D levels have higher virological response to treatment. However, there are not enough studies conducted in cirrhotic-only populations. The association between vitamin D and cirrhosis demonstrates a great potential for clinical application. The relation between vitamin D deficiency and the degree of liver function, degree of fibrosis and infectious complications could support its use as a prognostic index and a diagnostic tool.

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  • Authors+Show Affiliations

    ,

    Department of Gastroenterology, University Hospital of Patras, Patras, Greece.

    ,

    Department of Gastroenterology, University Hospital of Patras, Patras, Greece.

    ,

    Department of Gastroenterology, University Hospital of Patras, Patras, Greece.

    Department of Gastroenterology, University Hospital of Patras, Patras, Greece.

    Source

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    27366029

    Citation

    Konstantakis, Christos, et al. "Vitamin D Deficiency in Patients With Liver Cirrhosis." Annals of Gastroenterology, vol. 29, no. 3, 2016, pp. 297-306.
    Konstantakis C, Tselekouni P, Kalafateli M, et al. Vitamin D deficiency in patients with liver cirrhosis. Ann Gastroenterol. 2016;29(3):297-306.
    Konstantakis, C., Tselekouni, P., Kalafateli, M., & Triantos, C. (2016). Vitamin D deficiency in patients with liver cirrhosis. Annals of Gastroenterology, 29(3), pp. 297-306. doi:10.20524/aog.2016.0037.
    Konstantakis C, et al. Vitamin D Deficiency in Patients With Liver Cirrhosis. Ann Gastroenterol. 2016;29(3):297-306. PubMed PMID: 27366029.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D deficiency in patients with liver cirrhosis. AU - Konstantakis,Christos, AU - Tselekouni,Paraskevi, AU - Kalafateli,Maria, AU - Triantos,Christos, Y1 - 2016/04/25/ PY - 2015/07/16/received PY - 2016/03/26/accepted PY - 2016/7/2/entrez PY - 2016/7/2/pubmed PY - 2016/7/2/medline KW - Vitamin D KW - liver cirrhosis KW - prognosis KW - vitamin D deficiency KW - vitamin D insufficiency SP - 297 EP - 306 JF - Annals of gastroenterology JO - Ann Gastroenterol VL - 29 IS - 3 N2 - There is ongoing evidence that vitamin D is related to the pathophysiology of cirrhosis. Although the incidence of vitamin D deficiency in chronic liver diseases and cirrhosis is strongly documented, its pathogenic association with advanced liver fibrosis remains controversial. There is evidence of a significant relation of 25(OH)D levels with the degree of liver dysfunction, considering that an inverse correlation of 25(OH)D levels with both Child-Pugh score and Model for End-Stage Liver Disease has been reported. In addition, vitamin D deficiency has been shown to increase the risk for overall mortality and infections in patients with cirrhosis. Vitamin D deficiency has been also associated with advanced stages of hepatocellular carcinoma and poor prognosis. Finally, there are studies suggesting that patients with chronic hepatitis C and normal vitamin D levels have higher virological response to treatment. However, there are not enough studies conducted in cirrhotic-only populations. The association between vitamin D and cirrhosis demonstrates a great potential for clinical application. The relation between vitamin D deficiency and the degree of liver function, degree of fibrosis and infectious complications could support its use as a prognostic index and a diagnostic tool. SN - 1108-7471 UR - https://www.unboundmedicine.com/medline/citation/27366029/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27366029/ DB - PRIME DP - Unbound Medicine ER -