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A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults.
Neuropsychiatr Dis Treat 2016; 12:1715-23ND

Abstract

OBJECTIVE

The aim of the study was to investigate the efficacy and safety of St John's wort extract and selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression.

METHODS

Databases were searched for studies comparing efficacy and/or safety of St John's wort extract with SSRIs in depression from 1966 to April 2015. Stata software was used for statistical analysis.

RESULTS

Twenty-seven studies met the study entry criteria. A total of 3,126 patients with depression were included. St John's wort extract did not differ from SSRIs in clinical response, remission, and mean reduction in Hamilton Rating Scale for Depression score. St John's wort extract had a significantly lower rate of adverse events compared to SSRIs (summary relative risk: 0.77; 95% confidence interval: 0.70, 0.84, P=0.00) and had fewer withdrawals due to adverse events. St John's wort extract had superior safety in the management of patients with depression.

CONCLUSION

Both St John's wort extract and SSRIs are effective in treating mild-to-moderate depression. St John's wort extract is safer than SSRIs.

Authors+Show Affiliations

Department of Pediatrics, Beijing An'ding Hospital, Capital Medical University, Beijing, People's Republic of China.Department of Pediatrics, Beijing An'ding Hospital, Capital Medical University, Beijing, People's Republic of China; Beijing Institutes of Brain Disorders, Beijing, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27468236

Citation

Cui, Yong-Hua, and Yi Zheng. "A Meta-analysis On the Efficacy and Safety of St John's Wort Extract in Depression Therapy in Comparison With Selective Serotonin Reuptake Inhibitors in Adults." Neuropsychiatric Disease and Treatment, vol. 12, 2016, pp. 1715-23.
Cui YH, Zheng Y. A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults. Neuropsychiatr Dis Treat. 2016;12:1715-23.
Cui, Y. H., & Zheng, Y. (2016). A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults. Neuropsychiatric Disease and Treatment, 12, pp. 1715-23. doi:10.2147/NDT.S106752.
Cui YH, Zheng Y. A Meta-analysis On the Efficacy and Safety of St John's Wort Extract in Depression Therapy in Comparison With Selective Serotonin Reuptake Inhibitors in Adults. Neuropsychiatr Dis Treat. 2016;12:1715-23. PubMed PMID: 27468236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults. AU - Cui,Yong-Hua, AU - Zheng,Yi, Y1 - 2016/07/11/ PY - 2016/7/29/entrez PY - 2016/7/29/pubmed PY - 2016/7/29/medline KW - St John’s wort KW - depression KW - meta-analysis KW - selective serotonin reuptake inhibitors SP - 1715 EP - 23 JF - Neuropsychiatric disease and treatment JO - Neuropsychiatr Dis Treat VL - 12 N2 - OBJECTIVE: The aim of the study was to investigate the efficacy and safety of St John's wort extract and selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression. METHODS: Databases were searched for studies comparing efficacy and/or safety of St John's wort extract with SSRIs in depression from 1966 to April 2015. Stata software was used for statistical analysis. RESULTS: Twenty-seven studies met the study entry criteria. A total of 3,126 patients with depression were included. St John's wort extract did not differ from SSRIs in clinical response, remission, and mean reduction in Hamilton Rating Scale for Depression score. St John's wort extract had a significantly lower rate of adverse events compared to SSRIs (summary relative risk: 0.77; 95% confidence interval: 0.70, 0.84, P=0.00) and had fewer withdrawals due to adverse events. St John's wort extract had superior safety in the management of patients with depression. CONCLUSION: Both St John's wort extract and SSRIs are effective in treating mild-to-moderate depression. St John's wort extract is safer than SSRIs. SN - 1176-6328 UR - https://www.unboundmedicine.com/medline/citation/27468236/full_citation L2 - https://dx.doi.org/10.2147/NDT.S106752 DB - PRIME DP - Unbound Medicine ER -