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Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration.

Abstract

Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for researches of different compounds. Macro and micro nutrient deficiencies, along with vitamins, play an important role in not only meeting the calorific needs, but also reducing clinical complications and growth abnormalities. Symptoms of hyper protein metabolism, increased cell turnover, increased cardiac output, and appetite suppression due to enhanced cytokine production, might give us leads for better understanding of the mechanisms involved. Different nutritional approaches comprising of traditional herbal therapies, antioxidants, flavonoids, vitamins, minerals etc., reducing oxidative stress and blood aggregation, have been tried out to increase the health potential. Nutritional therapies may also serve complementary to the newer therapies using ozone, hematopoietic stem cell transplantation, antifungal medications, erythropoietin etc. Herein we try to present a holistic picture of the different patho-physiological mechanisms, and nutritional strategies adopted.

Links

Authors+Show Affiliations

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King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.

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King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.

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King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.

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National Brain Research Center, Manesar, Gurgaon, 122051 India.

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King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.

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Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, New York 11203 United State of America (USA).

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Department of Hematology, King Fahd Hospital of the Armed forces, Jeddah, Kingdom of Saudi Arabia ; Department of Medical Laboratory, King Fahd Hospital of the Armed forces, Jeddah, Kingdom of Saudi Arabia.

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Department of Hematology, Soliman Fakeeh Hospital Jeddah, Jeddah, Kingdom of Saudi Arabia.

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Department of Hematology, Umm Al Qura University, Faculty of Medicine, Makkah, Kingdom of Saudi Arabia.

King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.

Source

Nutrition & metabolism 13: 2016 pg 50

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27508000

Citation

TY - JOUR T1 - Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration. AU - Khan,Shahida A, AU - Damanhouri,Ghazi, AU - Ali,Ashraf, AU - Khan,Sarah A, AU - Khan,Aziz, AU - Bakillah,Ahmed, AU - Marouf,Samy, AU - Al Harbi,Ghazi, AU - Halawani,Saeed H, AU - Makki,Ahmad, Y1 - 2016/08/08/ PY - 2016///ecollection PY - 2016/3/20/received PY - 2016/7/22/accepted PY - 2016/8/8/epublish PY - 2016/8/11/entrez PY - 2016/8/11/pubmed PY - 2016/8/11/medline KW - Hydroxyurea KW - Nutrient deficiencies KW - Nutritional approaches KW - Sickle cell disease KW - Vaso-occlusive crisis SP - 50 EP - 50 JF - Nutrition & metabolism JO - Nutr Metab (Lond) VL - 13 N2 - Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for researches of different compounds. Macro and micro nutrient deficiencies, along with vitamins, play an important role in not only meeting the calorific needs, but also reducing clinical complications and growth abnormalities. Symptoms of hyper protein metabolism, increased cell turnover, increased cardiac output, and appetite suppression due to enhanced cytokine production, might give us leads for better understanding of the mechanisms involved. Different nutritional approaches comprising of traditional herbal therapies, antioxidants, flavonoids, vitamins, minerals etc., reducing oxidative stress and blood aggregation, have been tried out to increase the health potential. Nutritional therapies may also serve complementary to the newer therapies using ozone, hematopoietic stem cell transplantation, antifungal medications, erythropoietin etc. Herein we try to present a holistic picture of the different patho-physiological mechanisms, and nutritional strategies adopted. SN - 1743-7075 UR - https://www.unboundmedicine.com/medline/citation/27508000/full_citation ER -