Tags

Type your tag names separated by a space and hit enter

Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration.
Nutr Metab (Lond). 2016; 13:50.NM

Abstract

Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for researches of different compounds. Macro and micro nutrient deficiencies, along with vitamins, play an important role in not only meeting the calorific needs, but also reducing clinical complications and growth abnormalities. Symptoms of hyper protein metabolism, increased cell turnover, increased cardiac output, and appetite suppression due to enhanced cytokine production, might give us leads for better understanding of the mechanisms involved. Different nutritional approaches comprising of traditional herbal therapies, antioxidants, flavonoids, vitamins, minerals etc., reducing oxidative stress and blood aggregation, have been tried out to increase the health potential. Nutritional therapies may also serve complementary to the newer therapies using ozone, hematopoietic stem cell transplantation, antifungal medications, erythropoietin etc. Herein we try to present a holistic picture of the different patho-physiological mechanisms, and nutritional strategies adopted.

Links

PMC Free PDF

Authors+Show Affiliations

Khan SA
King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Damanhouri G
King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Ali A
King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Khan SA
National Brain Research Center, Manesar, Gurgaon, 122051 India.
Khan A
King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Bakillah A
Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, New York 11203 United State of America (USA).
Marouf S
Department of Hematology, King Fahd Hospital of the Armed forces, Jeddah, Kingdom of Saudi Arabia ; Department of Medical Laboratory, King Fahd Hospital of the Armed forces, Jeddah, Kingdom of Saudi Arabia.
Al Harbi G
Department of Hematology, Soliman Fakeeh Hospital Jeddah, Jeddah, Kingdom of Saudi Arabia.
Halawani SH
Department of Hematology, Umm Al Qura University, Faculty of Medicine, Makkah, Kingdom of Saudi Arabia.
Makki A
King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27508000

Citation

Khan, Shahida A., et al. "Precipitating Factors and Targeted Therapies in Combating the Perils of Sickle Cell Disease--- a Special Nutritional Consideration." Nutrition & Metabolism, vol. 13, 2016, p. 50.
Khan SA, Damanhouri G, Ali A, et al. Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration. Nutr Metab (Lond). 2016;13:50.
Khan, S. A., Damanhouri, G., Ali, A., Khan, S. A., Khan, A., Bakillah, A., Marouf, S., Al Harbi, G., Halawani, S. H., & Makki, A. (2016). Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration. Nutrition & Metabolism, 13, 50. https://doi.org/10.1186/s12986-016-0109-7
Khan SA, et al. Precipitating Factors and Targeted Therapies in Combating the Perils of Sickle Cell Disease--- a Special Nutritional Consideration. Nutr Metab (Lond). 2016;13:50. PubMed PMID: 27508000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration. AU - Khan,Shahida A, AU - Damanhouri,Ghazi, AU - Ali,Ashraf, AU - Khan,Sarah A, AU - Khan,Aziz, AU - Bakillah,Ahmed, AU - Marouf,Samy, AU - Al Harbi,Ghazi, AU - Halawani,Saeed H, AU - Makki,Ahmad, Y1 - 2016/08/08/ PY - 2016/03/20/received PY - 2016/07/22/accepted PY - 2016/8/11/entrez PY - 2016/8/11/pubmed PY - 2016/8/11/medline KW - Hydroxyurea KW - Nutrient deficiencies KW - Nutritional approaches KW - Sickle cell disease KW - Vaso-occlusive crisis SP - 50 EP - 50 JF - Nutrition & metabolism JO - Nutr Metab (Lond) VL - 13 N2 - Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for researches of different compounds. Macro and micro nutrient deficiencies, along with vitamins, play an important role in not only meeting the calorific needs, but also reducing clinical complications and growth abnormalities. Symptoms of hyper protein metabolism, increased cell turnover, increased cardiac output, and appetite suppression due to enhanced cytokine production, might give us leads for better understanding of the mechanisms involved. Different nutritional approaches comprising of traditional herbal therapies, antioxidants, flavonoids, vitamins, minerals etc., reducing oxidative stress and blood aggregation, have been tried out to increase the health potential. Nutritional therapies may also serve complementary to the newer therapies using ozone, hematopoietic stem cell transplantation, antifungal medications, erythropoietin etc. Herein we try to present a holistic picture of the different patho-physiological mechanisms, and nutritional strategies adopted. SN - 1743-7075 UR - https://www.unboundmedicine.com/medline/citation/27508000/full_citation DB - PRIME DP - Unbound Medicine ER -