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Effect of Pycnogenol on the Healing of Venous Ulcers.
Ann Vasc Surg. 2017 Jan; 38:212-219.AV

Abstract

BACKGROUND

Venous ulcers are common complications of chronic venous insufficiency that result in severe physical and mental suffering to patients. The oral administration of diosmin/hesperidin has been used as adjuvant therapy in the treatment of chronic venous insufficiency. The purpose of this study was to evaluate and compare the effect of pycnogenol and diosmin/hesperidin on the healing of venous ulcers.

METHODS

This longitudinal, prospective, randomized clinical trial was conducted with 30 adult patients with venous ulcers from a vascular surgery outpatient clinic of a university hospital. The patients were randomly allocated to 2 groups: Group 1 (n = 15) was treated with pycnogenol (50 mg orally, 3 times daily) and Group 2 (n = 15) was treated with diosmin/hesperidin (450/50 mg orally, twice daily). They were assessed every 15 days for 90 days. During follow-up visits, photo-documentation was obtained and the ulcer area and circumference of the affected limb were measured. Friedman's test and Mann-Whitney test were used to compare ulcer areas and circumference of affected limbs between and within groups at different time points. The level of significance was set at 5% (P < 0.05) for all tests.

RESULTS

Both the pycnogenol and diosmin/hesperidin treatments had a similar effect on the healing of venous ulcers and led to a significant decrease in the circumference of affected limbs (P < 0.0001).

CONCLUSION

The results suggest that pycnogenol has an adjuvant effect on the healing of venous ulcers, similar to diosmin/hesperidin.

Authors+Show Affiliations

Professional Master's Program in Applied Health Sciences, Department of Surgery, Universidade do Vale do Sapucaí, Pouso Alegre, Brazil. Electronic address: renatortoledo@hotmail.com.Department of Vascular Surgery, Faculdade de Ciencias Médicas de Minas Gerais, Belo Horizonte, Brazil.Professional Master's Program in Applied Health Sciences, Department of Surgery, Universidade do Vale do Sapucaí, Pouso Alegre, Brazil.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

27521821

Citation

Toledo, Renato Riera, et al. "Effect of Pycnogenol On the Healing of Venous Ulcers." Annals of Vascular Surgery, vol. 38, 2017, pp. 212-219.
Toledo RR, Santos MERC, Schnaider TB. Effect of Pycnogenol on the Healing of Venous Ulcers. Ann Vasc Surg. 2017;38:212-219.
Toledo, R. R., Santos, M. E. R. C., & Schnaider, T. B. (2017). Effect of Pycnogenol on the Healing of Venous Ulcers. Annals of Vascular Surgery, 38, 212-219. https://doi.org/10.1016/j.avsg.2016.04.014
Toledo RR, Santos MERC, Schnaider TB. Effect of Pycnogenol On the Healing of Venous Ulcers. Ann Vasc Surg. 2017;38:212-219. PubMed PMID: 27521821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Pycnogenol on the Healing of Venous Ulcers. AU - Toledo,Renato Riera, AU - Santos,Maria Elisabeth Rennó de Castro, AU - Schnaider,Taylor Brandão, Y1 - 2016/08/10/ PY - 2015/11/18/received PY - 2016/03/30/revised PY - 2016/04/12/accepted PY - 2016/8/16/pubmed PY - 2017/2/14/medline PY - 2016/8/14/entrez SP - 212 EP - 219 JF - Annals of vascular surgery JO - Ann Vasc Surg VL - 38 N2 - BACKGROUND: Venous ulcers are common complications of chronic venous insufficiency that result in severe physical and mental suffering to patients. The oral administration of diosmin/hesperidin has been used as adjuvant therapy in the treatment of chronic venous insufficiency. The purpose of this study was to evaluate and compare the effect of pycnogenol and diosmin/hesperidin on the healing of venous ulcers. METHODS: This longitudinal, prospective, randomized clinical trial was conducted with 30 adult patients with venous ulcers from a vascular surgery outpatient clinic of a university hospital. The patients were randomly allocated to 2 groups: Group 1 (n = 15) was treated with pycnogenol (50 mg orally, 3 times daily) and Group 2 (n = 15) was treated with diosmin/hesperidin (450/50 mg orally, twice daily). They were assessed every 15 days for 90 days. During follow-up visits, photo-documentation was obtained and the ulcer area and circumference of the affected limb were measured. Friedman's test and Mann-Whitney test were used to compare ulcer areas and circumference of affected limbs between and within groups at different time points. The level of significance was set at 5% (P < 0.05) for all tests. RESULTS: Both the pycnogenol and diosmin/hesperidin treatments had a similar effect on the healing of venous ulcers and led to a significant decrease in the circumference of affected limbs (P < 0.0001). CONCLUSION: The results suggest that pycnogenol has an adjuvant effect on the healing of venous ulcers, similar to diosmin/hesperidin. SN - 1615-5947 UR - https://www.unboundmedicine.com/medline/citation/27521821/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-5096(16)30602-1 DB - PRIME DP - Unbound Medicine ER -