Tags

Type your tag names separated by a space and hit enter

N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology.
Int J Neuropsychopharmacol. 2016 Dec; 19(12)IJ

Abstract

OBJECTIVE

The impact of lifetime dietary habits and their role in physical, mental, and social well-being has been the focus of considerable recent research. Omega-3 polyunsaturated fatty acids as a dietary constituent have been under the spotlight for decades. Omega-3 polyunsaturated fatty acids constitute key regulating factors of neurotransmission, neurogenesis, and neuroinflammation and are thereby fundamental for development, functioning, and aging of the CNS. Of note is the fact that these processes are altered in various psychiatric disorders, including attention deficit hyperactivity disorder, depression, and Alzheimer's disease.

DESIGN

Relevant literature was identified through a search of MEDLINE via PubMed using the following words, "n-3 PUFAs," "EPA," and "DHA" in combination with "stress," "cognition," "ADHD," "anxiety," "depression," "bipolar disorder," "schizophrenia," and "Alzheimer." The principal focus was on the role of omega-3 polyunsaturated fatty acids throughout the lifespan and their implication for psychopathologies. Recommendations for future investigation on the potential clinical value of omega-3 polyunsaturated fatty acids were examined.

RESULTS

The inconsistent and inconclusive results from randomized clinical trials limits the usage of omega-3 polyunsaturated fatty acids in clinical practice. However, a body of literature demonstrates an inverse correlation between omega-3 polyunsaturated fatty acid levels and quality of life/ psychiatric diseases. Specifically, older healthy adults showing low habitual intake of omega-3 polyunsaturated fatty acids benefit most from consuming them, showing improved age-related cognitive decline.

CONCLUSIONS

Although further studies are required, there is an exciting and growing body of research suggesting that omega-3 polyunsaturated fatty acids may have a potential clinical value in the prevention and treatment of psychopathologies.

Links

PMC Free PDF

Authors+Show Affiliations

Pusceddu MM
APC Microbiome Institute, University College Cork, Cork, Ireland (Drs Pusceddu, Cryan, and Dinan); Teagasc, Moorepark, Cork, Ireland (Drs Kelly and Stanton); Department of Anatomy and Neuroscience (Dr Cryan), and Department of Psychiatry and Neurobehavioural Science (Dr Dinan), University College Cork, Cork, Ireland.
Kelly P
APC Microbiome Institute, University College Cork, Cork, Ireland (Drs Pusceddu, Cryan, and Dinan); Teagasc, Moorepark, Cork, Ireland (Drs Kelly and Stanton); Department of Anatomy and Neuroscience (Dr Cryan), and Department of Psychiatry and Neurobehavioural Science (Dr Dinan), University College Cork, Cork, Ireland.
Stanton C
APC Microbiome Institute, University College Cork, Cork, Ireland (Drs Pusceddu, Cryan, and Dinan); Teagasc, Moorepark, Cork, Ireland (Drs Kelly and Stanton); Department of Anatomy and Neuroscience (Dr Cryan), and Department of Psychiatry and Neurobehavioural Science (Dr Dinan), University College Cork, Cork, Ireland.
Cryan JF
APC Microbiome Institute, University College Cork, Cork, Ireland (Drs Pusceddu, Cryan, and Dinan); Teagasc, Moorepark, Cork, Ireland (Drs Kelly and Stanton); Department of Anatomy and Neuroscience (Dr Cryan), and Department of Psychiatry and Neurobehavioural Science (Dr Dinan), University College Cork, Cork, Ireland.
Dinan TG
APC Microbiome Institute, University College Cork, Cork, Ireland (Drs Pusceddu, Cryan, and Dinan); Teagasc, Moorepark, Cork, Ireland (Drs Kelly and Stanton); Department of Anatomy and Neuroscience (Dr Cryan), and Department of Psychiatry and Neurobehavioural Science (Dr Dinan), University College Cork, Cork, Ireland. t.dinan@ucc.ie.

MeSH

Age FactorsAgingAnimalsBrainCognitionFatty Acids, Omega-3Feeding BehaviorHumansMental DisordersMental HealthProtective FactorsRisk Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27608809

Citation

Pusceddu, Matteo M., et al. "N-3 Polyunsaturated Fatty Acids Through the Lifespan: Implication for Psychopathology." The International Journal of Neuropsychopharmacology, vol. 19, no. 12, 2016.
Pusceddu MM, Kelly P, Stanton C, et al. N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology. Int J Neuropsychopharmacol. 2016;19(12).
Pusceddu, M. M., Kelly, P., Stanton, C., Cryan, J. F., & Dinan, T. G. (2016). N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology. The International Journal of Neuropsychopharmacology, 19(12). https://doi.org/10.1093/ijnp/pyw078
Pusceddu MM, et al. N-3 Polyunsaturated Fatty Acids Through the Lifespan: Implication for Psychopathology. Int J Neuropsychopharmacol. 2016;19(12) PubMed PMID: 27608809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology. AU - Pusceddu,Matteo M, AU - Kelly,Philip, AU - Stanton,Catherine, AU - Cryan,John F, AU - Dinan,Timothy G, Y1 - 2016/12/30/ PY - 2016/9/10/pubmed PY - 2018/1/9/medline PY - 2016/9/10/entrez KW - Alzheimer’s disease KW - bipolar disorder KW - depression KW - omega-3 polyunsaturated fatty acids (n-3 PUFAs) KW - schizophrenia JF - The international journal of neuropsychopharmacology JO - Int J Neuropsychopharmacol VL - 19 IS - 12 N2 - OBJECTIVE: The impact of lifetime dietary habits and their role in physical, mental, and social well-being has been the focus of considerable recent research. Omega-3 polyunsaturated fatty acids as a dietary constituent have been under the spotlight for decades. Omega-3 polyunsaturated fatty acids constitute key regulating factors of neurotransmission, neurogenesis, and neuroinflammation and are thereby fundamental for development, functioning, and aging of the CNS. Of note is the fact that these processes are altered in various psychiatric disorders, including attention deficit hyperactivity disorder, depression, and Alzheimer's disease. DESIGN: Relevant literature was identified through a search of MEDLINE via PubMed using the following words, "n-3 PUFAs," "EPA," and "DHA" in combination with "stress," "cognition," "ADHD," "anxiety," "depression," "bipolar disorder," "schizophrenia," and "Alzheimer." The principal focus was on the role of omega-3 polyunsaturated fatty acids throughout the lifespan and their implication for psychopathologies. Recommendations for future investigation on the potential clinical value of omega-3 polyunsaturated fatty acids were examined. RESULTS: The inconsistent and inconclusive results from randomized clinical trials limits the usage of omega-3 polyunsaturated fatty acids in clinical practice. However, a body of literature demonstrates an inverse correlation between omega-3 polyunsaturated fatty acid levels and quality of life/ psychiatric diseases. Specifically, older healthy adults showing low habitual intake of omega-3 polyunsaturated fatty acids benefit most from consuming them, showing improved age-related cognitive decline. CONCLUSIONS: Although further studies are required, there is an exciting and growing body of research suggesting that omega-3 polyunsaturated fatty acids may have a potential clinical value in the prevention and treatment of psychopathologies. SN - 1469-5111 UR - https://www.unboundmedicine.com/medline/citation/27608809/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓25 ↑185]

Related Citations

    More

    Others Viewed