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Maternal pre-pregnancy and gestational diabetes, obesity, gestational weight gain, and risk of cancer in young children: a population-based study in California.

Abstract

PURPOSE

We aimed to examine the influence of pre-pregnancy diabetes, pre-pregnancy body mass index (BMI), gestational diabetes, and gestational weight gain on childhood cancer risk in offspring.

METHODS

We identified cancer cases (n = 11,149) younger than age 6 years at diagnosis from the California Cancer Registry registered between 1988 and 2013. Controls (n = 270,147) were randomly sampled from California birth records, and frequency matched by year of birth to all childhood cancers during the study period. Exposure and covariate information were extracted from birth records. Unconditional logistic regression models were generated to assess the importance of pre-pregnancy diabetes, pre-pregnancy BMI, gestational diabetes, and gestational weight gain on childhood cancer risk.

RESULTS

We observed increased risks of acute lymphoblastic leukemia and Wilms' tumor in children of mothers with pre-pregnancy diabetes [odds ratio (OR) 95 % confidence interval (CI) 1.37 (1.11, 1.69); OR (95 % CI) 1.45 (0.97, 2.18), respectively]. When born to mothers who were overweight prior to pregnancy (BMI 25-<30), children were at increased risk of leukemia [OR (95 % CI) 1.27 (1.01, 1.59)]. Insufficient gestational weight gain increased the risk of acute myeloid leukemia [OR (95 % CI) 1.50 (0.92, 2.42)] while excessive gestational weight gain increased the risk of astrocytomas [OR (95 % CI) 1.56 (0.97, 2.50)]. No associations were found between gestational diabetes and childhood cancer risk in offspring.

CONCLUSIONS

We estimated elevated risks of several childhood cancers in the offspring of mothers who had diabetes and were overweight prior to pregnancy, as well as mothers who gained insufficient or excessive weight. Since few studies have focused on these factors in relation to childhood cancer, replication of our findings in future studies is warranted.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.

    ,

    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.

    ,

    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.

    ,

    Department of Preventive Medicine, USC/Keck School of Medicine, Los Angeles, CA, USA.

    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA. jeheck@ucla.edu.

    Source

    Cancer causes & control : CCC 27:10 2016 10 pg 1273-85

    MeSH

    Adult
    Birth Weight
    Body Mass Index
    California
    Child
    Diabetes, Gestational
    Female
    Humans
    Logistic Models
    Male
    Neoplasms
    Obesity
    Odds Ratio
    Overweight
    Pregnancy
    Pregnancy Complications
    Pregnancy in Diabetics
    Weight Gain

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27613707

    Citation

    Contreras, Zuelma A., et al. "Maternal Pre-pregnancy and Gestational Diabetes, Obesity, Gestational Weight Gain, and Risk of Cancer in Young Children: a Population-based Study in California." Cancer Causes & Control : CCC, vol. 27, no. 10, 2016, pp. 1273-85.
    Contreras ZA, Ritz B, Virk J, et al. Maternal pre-pregnancy and gestational diabetes, obesity, gestational weight gain, and risk of cancer in young children: a population-based study in California. Cancer Causes Control. 2016;27(10):1273-85.
    Contreras, Z. A., Ritz, B., Virk, J., Cockburn, M., & Heck, J. E. (2016). Maternal pre-pregnancy and gestational diabetes, obesity, gestational weight gain, and risk of cancer in young children: a population-based study in California. Cancer Causes & Control : CCC, 27(10), pp. 1273-85. doi:10.1007/s10552-016-0807-5.
    Contreras ZA, et al. Maternal Pre-pregnancy and Gestational Diabetes, Obesity, Gestational Weight Gain, and Risk of Cancer in Young Children: a Population-based Study in California. Cancer Causes Control. 2016;27(10):1273-85. PubMed PMID: 27613707.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Maternal pre-pregnancy and gestational diabetes, obesity, gestational weight gain, and risk of cancer in young children: a population-based study in California. AU - Contreras,Zuelma A, AU - Ritz,Beate, AU - Virk,Jasveer, AU - Cockburn,Myles, AU - Heck,Julia E, Y1 - 2016/09/09/ PY - 2016/04/21/received PY - 2016/08/30/accepted PY - 2016/9/11/entrez PY - 2016/9/11/pubmed PY - 2017/6/3/medline KW - BMI KW - Childhood cancer epidemiology KW - Diabetes KW - Gestational weight gain KW - Risk factors SP - 1273 EP - 85 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 27 IS - 10 N2 - PURPOSE: We aimed to examine the influence of pre-pregnancy diabetes, pre-pregnancy body mass index (BMI), gestational diabetes, and gestational weight gain on childhood cancer risk in offspring. METHODS: We identified cancer cases (n = 11,149) younger than age 6 years at diagnosis from the California Cancer Registry registered between 1988 and 2013. Controls (n = 270,147) were randomly sampled from California birth records, and frequency matched by year of birth to all childhood cancers during the study period. Exposure and covariate information were extracted from birth records. Unconditional logistic regression models were generated to assess the importance of pre-pregnancy diabetes, pre-pregnancy BMI, gestational diabetes, and gestational weight gain on childhood cancer risk. RESULTS: We observed increased risks of acute lymphoblastic leukemia and Wilms' tumor in children of mothers with pre-pregnancy diabetes [odds ratio (OR) 95 % confidence interval (CI) 1.37 (1.11, 1.69); OR (95 % CI) 1.45 (0.97, 2.18), respectively]. When born to mothers who were overweight prior to pregnancy (BMI 25-<30), children were at increased risk of leukemia [OR (95 % CI) 1.27 (1.01, 1.59)]. Insufficient gestational weight gain increased the risk of acute myeloid leukemia [OR (95 % CI) 1.50 (0.92, 2.42)] while excessive gestational weight gain increased the risk of astrocytomas [OR (95 % CI) 1.56 (0.97, 2.50)]. No associations were found between gestational diabetes and childhood cancer risk in offspring. CONCLUSIONS: We estimated elevated risks of several childhood cancers in the offspring of mothers who had diabetes and were overweight prior to pregnancy, as well as mothers who gained insufficient or excessive weight. Since few studies have focused on these factors in relation to childhood cancer, replication of our findings in future studies is warranted. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/27613707/full_citation L2 - https://doi.org/10.1007/s10552-016-0807-5 DB - PRIME DP - Unbound Medicine ER -