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Dairy, calcium, vitamin D and ovarian cancer risk in African-American women.
Br J Cancer. 2016 Oct 25; 115(9):1122-1130.BJ

Abstract

BACKGROUND

No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency.

METHODS

We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African-American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS

An increased ovarian cancer risk was observed for whole milk consumption and lactose intake (highest quartile vs lowest: OR=1.97, 95% CI: 1.25-3.10;P-trend: 0.008). Calcium intake was associated with a decreased risk of ovarian cancer (OR=0.51, 95 CI%: 0.30-0.86; P-trend: 0.009), but vitamin D intake was not. Longer sun exposure in summer months was found to predict a lower risk (OR=0.71, 95% CI: 0.51-0.99; P-trend: 0.049).

CONCLUSIONS

Our findings suggest that a high-calcium, low-lactose diet, and sun exposure in summer months may reduce the risk of ovarian cancer in African-American women.

Links

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Authors+Show Affiliations

Qin B
Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Moorman PG
Department of Community and Family Medicine, Duke Cancer Institute, Durham, NC 27705, USA.
Alberg AJ
Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Barnholtz-Sloan JS
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Bondy M
Cancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, TX 77030, USA.
Cote ML
Department of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Funkhouser E
Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Peters ES
Epidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA 70112, USA.
Schwartz AG
Department of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Terry P
Departments of Public Health and Surgery, University of Tennessee-Knoxville, Knoxville, TN 37996, USA.
Schildkraut JM
Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA.
Bandera EV
Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.

MeSH

AdultBlack or African AmericanAgedCalcium, DietaryCase-Control StudiesDairy ProductsFemaleHumansMiddle AgedNutrition SurveysOvarian NeoplasmsRisk FactorsUnited StatesVitamin DVitamin D DeficiencyYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27632371

Citation

Qin, Bo, et al. "Dairy, Calcium, Vitamin D and Ovarian Cancer Risk in African-American Women." British Journal of Cancer, vol. 115, no. 9, 2016, pp. 1122-1130.
Qin B, Moorman PG, Alberg AJ, et al. Dairy, calcium, vitamin D and ovarian cancer risk in African-American women. Br J Cancer. 2016;115(9):1122-1130.
Qin, B., Moorman, P. G., Alberg, A. J., Barnholtz-Sloan, J. S., Bondy, M., Cote, M. L., Funkhouser, E., Peters, E. S., Schwartz, A. G., Terry, P., Schildkraut, J. M., & Bandera, E. V. (2016). Dairy, calcium, vitamin D and ovarian cancer risk in African-American women. British Journal of Cancer, 115(9), 1122-1130. https://doi.org/10.1038/bjc.2016.289
Qin B, et al. Dairy, Calcium, Vitamin D and Ovarian Cancer Risk in African-American Women. Br J Cancer. 2016 Oct 25;115(9):1122-1130. PubMed PMID: 27632371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy, calcium, vitamin D and ovarian cancer risk in African-American women. AU - Qin,Bo, AU - Moorman,Patricia G, AU - Alberg,Anthony J, AU - Barnholtz-Sloan,Jill S, AU - Bondy,Melissa, AU - Cote,Michele L, AU - Funkhouser,Ellen, AU - Peters,Edward S, AU - Schwartz,Ann G, AU - Terry,Paul, AU - Schildkraut,Joellen M, AU - Bandera,Elisa V, Y1 - 2016/09/15/ PY - 2016/05/16/received PY - 2016/08/08/revised PY - 2016/08/16/accepted PY - 2016/10/26/pubmed PY - 2017/5/24/medline PY - 2016/9/16/entrez SP - 1122 EP - 1130 JF - British journal of cancer JO - Br J Cancer VL - 115 IS - 9 N2 - BACKGROUND: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency. METHODS: We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African-American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: An increased ovarian cancer risk was observed for whole milk consumption and lactose intake (highest quartile vs lowest: OR=1.97, 95% CI: 1.25-3.10;P-trend: 0.008). Calcium intake was associated with a decreased risk of ovarian cancer (OR=0.51, 95 CI%: 0.30-0.86; P-trend: 0.009), but vitamin D intake was not. Longer sun exposure in summer months was found to predict a lower risk (OR=0.71, 95% CI: 0.51-0.99; P-trend: 0.049). CONCLUSIONS: Our findings suggest that a high-calcium, low-lactose diet, and sun exposure in summer months may reduce the risk of ovarian cancer in African-American women. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/27632371/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓22 ↑48]

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