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Association between physical activity and inflammatory bowel disease risk: A meta-analysis.
Dig Liver Dis. 2016 Dec; 48(12):1425-1431.DL

Abstract

BACKGROUND

Previous studies of an association between physical activity and inflammatory bowel disease have yielded conflicting results.

AIM

This meta-analysis was conducted to clarify whether there is an association between physical activity and inflammatory bowel disease.

METHODS

The PubMed and Web of Science databases were searched for relevant studies published up to October 2015. Data were extracted and the summary relative risks (RRs) were calculated using a random effects or a fixed-effects model, according to heterogeneity.

RESULTS

Seven studies were included in the analysis. Relative to individuals with low physical activity, those who participated in high physical activity had an RR of 0.63 (95% CI, 0.50-0.79) for developing Crohn's disease. In stratified analyses, a significantly lower risk for Crohn's disease was associated with high physical activity in Europeans only (RR, 0.62; 95% CI, 0.43-0.91); population-based control studies (RR, 0.56; 95% CI, 0.41-0.76); and case-control studies (RR, 0.56; 95% CI, 0.41-0.75). The data of 6 studies were pooled to analyze the effect of physical activity on the risk of ulcerative colitis, and no significant association was found (RR, 0.82; 95% CI, 0.68-1.00).

CONCLUSIONS

The pooled results of observational studies support that physical activity has a protective effect against Crohn's disease.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Gastroenterology, Changzhou No. 2 Hospital, Affiliated with Nanjing Medical University, Changzhou City, Jiangsu Province, China.

Department of Gastroenterology, Changzhou No. 2 Hospital, Affiliated with Nanjing Medical University, Changzhou City, Jiangsu Province, China.

Department of Gastroenterology, Changzhou No. 2 Hospital, Affiliated with Nanjing Medical University, Changzhou City, Jiangsu Province, China.

Department of Gastroenterology, Changzhou No. 2 Hospital, Affiliated with Nanjing Medical University, Changzhou City, Jiangsu Province, China.

Department of Gastroenterology, Changzhou No. 2 Hospital, Affiliated with Nanjing Medical University, Changzhou City, Jiangsu Province, China.

Department of Gastroenterology, Changzhou No. 2 Hospital, Affiliated with Nanjing Medical University, Changzhou City, Jiangsu Province, China. Electronic address: wxy20009@126.com.

MeSH

Crohn DiseaseExerciseHumansObservational Studies as TopicRisk Assessment

Pub Type(s)

Journal Article

Meta-Analysis

Review

Language

eng

PubMed ID

27671622

Citation

Wang, Qiang, et al. "Association Between Physical Activity and Inflammatory Bowel Disease Risk: a Meta-analysis." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 48, no. 12, 2016, pp. 1425-1431.

Wang Q, Xu KQ, Qin XR, et al. Association between physical activity and inflammatory bowel disease risk: A meta-analysis. Dig Liver Dis. 2016;48(12):1425-1431.

Wang, Q., Xu, K. Q., Qin, X. R., Wen-Lu, ., Yan-Liu, ., & Wang, X. Y. (2016). Association between physical activity and inflammatory bowel disease risk: A meta-analysis. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 48(12), 1425-1431. https://doi.org/10.1016/j.dld.2016.08.129

Wang Q, et al. Association Between Physical Activity and Inflammatory Bowel Disease Risk: a Meta-analysis. Dig Liver Dis. 2016;48(12):1425-1431. PubMed PMID: 27671622.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Association between physical activity and inflammatory bowel disease risk: A meta-analysis. AU - Wang,Qiang, AU - Xu,Ke-Qun, AU - Qin,Xiang-Rong, AU - Wen-Lu,, AU - Yan-Liu,, AU - Wang,Xiao-Yong, Y1 - 2016/09/13/ PY - 2016/06/29/received PY - 2016/08/17/revised PY - 2016/08/27/accepted PY - 2016/9/28/pubmed PY - 2019/3/21/medline PY - 2016/9/28/entrez KW - Crohn's disease KW - Inflammatory bowel disease KW - Meta-analysis KW - Physical activity KW - Ulcerative colitis SP - 1425 EP - 1431 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 48 IS - 12 N2 - BACKGROUND: Previous studies of an association between physical activity and inflammatory bowel disease have yielded conflicting results. AIM: This meta-analysis was conducted to clarify whether there is an association between physical activity and inflammatory bowel disease. METHODS: The PubMed and Web of Science databases were searched for relevant studies published up to October 2015. Data were extracted and the summary relative risks (RRs) were calculated using a random effects or a fixed-effects model, according to heterogeneity. RESULTS: Seven studies were included in the analysis. Relative to individuals with low physical activity, those who participated in high physical activity had an RR of 0.63 (95% CI, 0.50-0.79) for developing Crohn's disease. In stratified analyses, a significantly lower risk for Crohn's disease was associated with high physical activity in Europeans only (RR, 0.62; 95% CI, 0.43-0.91); population-based control studies (RR, 0.56; 95% CI, 0.41-0.76); and case-control studies (RR, 0.56; 95% CI, 0.41-0.75). The data of 6 studies were pooled to analyze the effect of physical activity on the risk of ulcerative colitis, and no significant association was found (RR, 0.82; 95% CI, 0.68-1.00). CONCLUSIONS: The pooled results of observational studies support that physical activity has a protective effect against Crohn's disease. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/27671622/full_citation DB - PRIME DP - Unbound Medicine ER -