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Myocardial energetics and the role of micronutrients in heart failure: a critical review.

Abstract

Heart failure is a multifactorial disease with poor prognosis. There are many hypotheses regarding the cause of heart failure. Leading among them are the hemodynamic and the neuro-hormonal hypotheses. Although the energy depletion hypothesis has been fairly recent, there is evidence suggesting that declining bioenergy plays a major role in heart failure. This review explored the myocardial energy depletion hypothesis from the role of micronutrients in correcting and alleviating symptoms of heart failure. Even though focus was on key nutrients such as coenzyme Q10, thiamine, riboflavin, L-carnitine, and taurine, emphasis was on the combined effect of multiple micronutrients as a whole. Search from databases from 2000 to 2015 produced four clinical studies using multiple micronutrients on heart failure. Evidence from the studies show that using high doses of multiple micronutrients may have positive effects on heart failure and simultaneously support the myocardial energy depletion hypothesis.

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  • Authors+Show Affiliations

    ,

    Department of Graduate Studies, Research and Commercialization, Cyberjaya University College of Medical Sciences Selangor, Malaysia.

    ,

    Dr. Rath Research Institute Santa Clara, CA 95050, USA.

    Dr. Rath Research Institute Santa Clara, CA 95050, USA.

    Source

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    27679743

    Citation

    Wong, Ang-Peng, et al. "Myocardial Energetics and the Role of Micronutrients in Heart Failure: a Critical Review." American Journal of Cardiovascular Disease, vol. 6, no. 3, 2016, pp. 81-92.
    Wong AP, Niedzwiecki A, Rath M. Myocardial energetics and the role of micronutrients in heart failure: a critical review. Am J Cardiovasc Dis. 2016;6(3):81-92.
    Wong, A. P., Niedzwiecki, A., & Rath, M. (2016). Myocardial energetics and the role of micronutrients in heart failure: a critical review. American Journal of Cardiovascular Disease, 6(3), pp. 81-92.
    Wong AP, Niedzwiecki A, Rath M. Myocardial Energetics and the Role of Micronutrients in Heart Failure: a Critical Review. Am J Cardiovasc Dis. 2016;6(3):81-92. PubMed PMID: 27679743.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Myocardial energetics and the role of micronutrients in heart failure: a critical review. AU - Wong,Ang-Peng, AU - Niedzwiecki,Aleksandra, AU - Rath,Matthias, Y1 - 2016/09/15/ PY - 2016/01/13/received PY - 2016/08/19/accepted PY - 2016/9/29/entrez PY - 2016/9/30/pubmed PY - 2016/9/30/medline KW - Heart failure KW - Krebs cycle KW - adenosine triphosphate KW - myocardial energetics SP - 81 EP - 92 JF - American journal of cardiovascular disease JO - Am J Cardiovasc Dis VL - 6 IS - 3 N2 - Heart failure is a multifactorial disease with poor prognosis. There are many hypotheses regarding the cause of heart failure. Leading among them are the hemodynamic and the neuro-hormonal hypotheses. Although the energy depletion hypothesis has been fairly recent, there is evidence suggesting that declining bioenergy plays a major role in heart failure. This review explored the myocardial energy depletion hypothesis from the role of micronutrients in correcting and alleviating symptoms of heart failure. Even though focus was on key nutrients such as coenzyme Q10, thiamine, riboflavin, L-carnitine, and taurine, emphasis was on the combined effect of multiple micronutrients as a whole. Search from databases from 2000 to 2015 produced four clinical studies using multiple micronutrients on heart failure. Evidence from the studies show that using high doses of multiple micronutrients may have positive effects on heart failure and simultaneously support the myocardial energy depletion hypothesis. SN - 2160-200X UR - https://www.unboundmedicine.com/medline/citation/27679743/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27679743/ DB - PRIME DP - Unbound Medicine ER -