Multiple sclerosis and inflammatory bowel diseases: a systematic review and meta-analysis.
J Neurol. 2017 Feb; 264(2):254-259.JN

Abstract

The association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) has been suggested, apart from their common epidemiological and immunological patterns, also due to observations of increased incidence of both IBD among MS patients and MS among IBD patients. We estimated the risk of concurrent IBD and MS comorbidity, using data from all available case-control studies. We calculated the corresponding Risk ratios (RRs) in each included case-control study to express the risk of IBD and MS concurrence at a given population. We performed additional subgroup analyses according to the type of registry from which the data of the cases were exported (IBD or MS registry) and the IBD type (Crohn's disease, CD or Ulcerative colitis, UC). We included 10 studies, comprising a total of 1,086,430 patients (0.08% of them with concurrent IBD and MS). Pooled RR for IBD/MS comorbitity was 1.54 (95% CI 1.40-1.67; p < 0.0001) with no differences (p = 0.91) among IBD and MS registries (RR 1.53, 95% CI 1.36-1.72, p < 0.001 for MS comorbidity in IBD patients vs. RR 1.55, 95% CI 1.32-1.81, p < 0.001 for IBD comorbidity in MS patients). No difference was also found on the risk of MS comorbidity among patients with CD or UC (RR 1.52, 95% CI 1.34-1.72, p < 0.001 vs. RR 1.55, 95% CI 1.38-1.74, p < 0.001; p for subgroup differences: 0.84). In all analyses no evidence of heterogeneity or publication bias was detected. Both IBD and MS patients seem to have a fifty-percent increased risk of MS or IBD comorbidity, respectively, with no apparent differences between patients with CD or UC.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Kosmidou M

First Division of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.

Katsanos AH

Department of Neurology, School of Medicine, University of Ioannina, University Campus, 45110, Ioannina, Greece.

Katsanos KH

HepatoGastroenterology Unit, School of Medicine, University of Ioannina, Ioannina, Greece.

Kyritsis AP

Department of Neurology, School of Medicine, University of Ioannina, University Campus, 45110, Ioannina, Greece. Neurosurgical Research Institute, University of Ioannina, Ioannina, Greece.

Tsivgoulis G

Second Department of Neurology, School of Medicine, University of Athens, Athens, Greece. Department of Neurology, University of Tennessee Health Science Center, Memphis, USA.

Christodoulou D

HepatoGastroenterology Unit, School of Medicine, University of Ioannina, Ioannina, Greece.

Giannopoulos S

Department of Neurology, School of Medicine, University of Ioannina, University Campus, 45110, Ioannina, Greece. sgiannop@uoi.gr. Neurosurgical Research Institute, University of Ioannina, Ioannina, Greece. sgiannop@uoi.gr.

MeSH

ComorbidityHumansInflammatory Bowel DiseasesMultiple Sclerosis

Pub Type(s)

Journal Article

Meta-Analysis

Systematic Review

Language

eng

PubMed ID

27878439

Citation

Kosmidou, Maria, et al. "Multiple Sclerosis and Inflammatory Bowel Diseases: a Systematic Review and Meta-analysis." Journal of Neurology, vol. 264, no. 2, 2017, pp. 254-259.

Kosmidou M, Katsanos AH, Katsanos KH, et al. Multiple sclerosis and inflammatory bowel diseases: a systematic review and meta-analysis. J Neurol. 2017;264(2):254-259.

Kosmidou, M., Katsanos, A. H., Katsanos, K. H., Kyritsis, A. P., Tsivgoulis, G., Christodoulou, D., & Giannopoulos, S. (2017). Multiple sclerosis and inflammatory bowel diseases: a systematic review and meta-analysis. Journal of Neurology, 264(2), 254-259. https://doi.org/10.1007/s00415-016-8340-8

Kosmidou M, et al. Multiple Sclerosis and Inflammatory Bowel Diseases: a Systematic Review and Meta-analysis. J Neurol. 2017;264(2):254-259. PubMed PMID: 27878439.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Multiple sclerosis and inflammatory bowel diseases: a systematic review and meta-analysis. AU - Kosmidou,Maria, AU - Katsanos,Aristeidis H, AU - Katsanos,Konstantinos H, AU - Kyritsis,Athanassios P, AU - Tsivgoulis,Georgios, AU - Christodoulou,Dimitrios, AU - Giannopoulos,Sotirios, Y1 - 2016/11/22/ PY - 2016/10/10/received PY - 2016/11/8/accepted PY - 2016/11/24/pubmed PY - 2017/6/13/medline PY - 2016/11/24/entrez KW - Co-existence KW - Crohn’s disease KW - Demyelination KW - Inflammatory bowel diseases KW - Multiple sclerosis KW - Ulcerative colitis SP - 254 EP - 259 JF - Journal of neurology JO - J Neurol VL - 264 IS - 2 N2 - The association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) has been suggested, apart from their common epidemiological and immunological patterns, also due to observations of increased incidence of both IBD among MS patients and MS among IBD patients. We estimated the risk of concurrent IBD and MS comorbidity, using data from all available case-control studies. We calculated the corresponding Risk ratios (RRs) in each included case-control study to express the risk of IBD and MS concurrence at a given population. We performed additional subgroup analyses according to the type of registry from which the data of the cases were exported (IBD or MS registry) and the IBD type (Crohn's disease, CD or Ulcerative colitis, UC). We included 10 studies, comprising a total of 1,086,430 patients (0.08% of them with concurrent IBD and MS). Pooled RR for IBD/MS comorbitity was 1.54 (95% CI 1.40-1.67; p < 0.0001) with no differences (p = 0.91) among IBD and MS registries (RR 1.53, 95% CI 1.36-1.72, p < 0.001 for MS comorbidity in IBD patients vs. RR 1.55, 95% CI 1.32-1.81, p < 0.001 for IBD comorbidity in MS patients). No difference was also found on the risk of MS comorbidity among patients with CD or UC (RR 1.52, 95% CI 1.34-1.72, p < 0.001 vs. RR 1.55, 95% CI 1.38-1.74, p < 0.001; p for subgroup differences: 0.84). In all analyses no evidence of heterogeneity or publication bias was detected. Both IBD and MS patients seem to have a fifty-percent increased risk of MS or IBD comorbidity, respectively, with no apparent differences between patients with CD or UC. SN - 1432-1459 UR - https://www.unboundmedicine.com/medline/citation/27878439/full_citation DB - PRIME DP - Unbound Medicine ER -

Tags

Multiple sclerosis and inflammatory bowel diseases: a systematic review and meta-analysis.J Neurol. 2017 Feb; 264(2):254-259.JN