Tags

Type your tag names separated by a space and hit enter

Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ‎with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study.
Iran J Psychiatry 2016; 11(3):191-197IJ

Abstract

Objective:

Because of functional impairment caused by generalized anxiety disorder and due to cognitive side ‎effects of many anti-anxiety agents, in this study we aimed to evaluate the influence of Passion ‎flower standardized extract on reaction time in patients with generalized anxiety disorder.‎ Method: Thirty patients aged 18 to 50 years of age, who were diagnosed with generalized anxiety disorder and ‎fulfilled the study criteria, entered this double-blind placebo-controlled study. Reaction time was ‎measured at baseline and after one month of treatment using computerized software. Correct ‎responses, omission and substitution errors and the mean time of correct responses (reaction time) in ‎both visual and auditory tests were collected. The analysis was performed between the two groups ‎and within each group utilizing SPSS PASW- statics, Version 18. P-value less than 0.05 was ‎considered statistically significant.‎

Results:

All the participants were initiated on Sertraline 50 mg/day, and the dosage was increased to 100 ‎mg / day after two weeks. Fourteen patients received Pasipy (Passion Flower) 15 drops three times ‎daily and 16 received placebo concurrently. Inter-group comparison proved no significant difference ‎in any of the test items between assortments while a significant decline was observed in auditory ‎omission errors in passion flower group after on month of treatment using intra-group analysis.‎‎

Conclusion:

This study noted that passion flower might be suitable as an add-on in the treatment of generalized ‎anxiety disorder with low side effects. Further studies with longer duration are recommended to ‎confirm the results of this study.‎.

Authors+Show Affiliations

Department of Clinical Pharmacy, Faculty of Pharmacy, Islamic Azad University of Pharmaceutical ‎Sciences, Tehran, Iran.Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, ‎Tehran, Iran.Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.Research Centre for Intelligent Signal Processing, Tehran, Iran.Psychiatric and Psychology Research Centre, Roozbeh Psychiatric Hospital, Tehran University of ‎Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27928252

Citation

Nojoumi, Mandana, et al. "Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, On Reaction Time in Patients ‎with Generalized Anxiety Disorder: a Double-Blind Placebo-Controlled Study." Iranian Journal of Psychiatry, vol. 11, no. 3, 2016, pp. 191-197.
Nojoumi M, Ghaeli P, Salimi S, et al. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ‎with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;11(3):191-197.
Nojoumi, M., Ghaeli, P., Salimi, S., Sharifi, A., & Raisi, F. (2016). Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ‎with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iranian Journal of Psychiatry, 11(3), pp. 191-197.
Nojoumi M, et al. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, On Reaction Time in Patients ‎with Generalized Anxiety Disorder: a Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;11(3):191-197. PubMed PMID: 27928252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ‎with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. AU - Nojoumi,Mandana, AU - Ghaeli,Padideh, AU - Salimi,Samrand, AU - Sharifi,Ali, AU - Raisi,Firoozeh, PY - 2016/12/9/entrez PY - 2016/12/9/pubmed PY - 2016/12/9/medline KW - Generalized Anxiety Disorder KW - Mental Processing KW - Passion Flower KW - Reaction Time KW - Sertraline‎ SP - 191 EP - 197 JF - Iranian journal of psychiatry JO - Iran J Psychiatry VL - 11 IS - 3 N2 - Objective: Because of functional impairment caused by generalized anxiety disorder and due to cognitive side ‎effects of many anti-anxiety agents, in this study we aimed to evaluate the influence of Passion ‎flower standardized extract on reaction time in patients with generalized anxiety disorder.‎ Method: Thirty patients aged 18 to 50 years of age, who were diagnosed with generalized anxiety disorder and ‎fulfilled the study criteria, entered this double-blind placebo-controlled study. Reaction time was ‎measured at baseline and after one month of treatment using computerized software. Correct ‎responses, omission and substitution errors and the mean time of correct responses (reaction time) in ‎both visual and auditory tests were collected. The analysis was performed between the two groups ‎and within each group utilizing SPSS PASW- statics, Version 18. P-value less than 0.05 was ‎considered statistically significant.‎ Results: All the participants were initiated on Sertraline 50 mg/day, and the dosage was increased to 100 ‎mg / day after two weeks. Fourteen patients received Pasipy (Passion Flower) 15 drops three times ‎daily and 16 received placebo concurrently. Inter-group comparison proved no significant difference ‎in any of the test items between assortments while a significant decline was observed in auditory ‎omission errors in passion flower group after on month of treatment using intra-group analysis.‎‎ Conclusion: This study noted that passion flower might be suitable as an add-on in the treatment of generalized ‎anxiety disorder with low side effects. Further studies with longer duration are recommended to ‎confirm the results of this study.‎. SN - 1735-4587 UR - https://www.unboundmedicine.com/medline/citation/27928252/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27928252/ DB - PRIME DP - Unbound Medicine ER -