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Medical Management of Endometriosis in Patients with Chronic Pelvic Pain.
Semin Reprod Med. 2017 01; 35(1):38-53.SR

Abstract

Endometriosis is a common cause of pelvic pain in women of reproductive age. Traditional medical therapies are hormonal in nature, including estrogen-progestin contraceptives, progestins, and gonadotropin-releasing hormone (GnRH) agonists. Other hormonal options are androgens and aromatase inhibitors, with research also suggesting a possible role for GnRH antagonists and selective progesterone receptor modulators. Other than nonsteroidal anti-inflammatories, further work is required for nonhormonal therapies such as antiangiogenic and immune-modulating drugs. Medical treatment of endometriosis can be complex, and requires consideration of side effects, the anatomic type of endometriosis, role of surgery, current infertility or future fertility desires, and other contributors to pain (e.g., central sensitization). These factors should be discussed for each patient, to ensure personalized treatment and optimal outcomes.

Authors+Show Affiliations

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, The University of British Columbia, Vancouver, Canada.Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, The University of British Columbia, Vancouver, Canada.Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, The University of British Columbia, Vancouver, Canada.Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, The University of British Columbia, Vancouver, Canada.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28002850

Citation

Bedaiwy, Mohamed A., et al. "Medical Management of Endometriosis in Patients With Chronic Pelvic Pain." Seminars in Reproductive Medicine, vol. 35, no. 1, 2017, pp. 38-53.
Bedaiwy MA, Allaire C, Yong P, et al. Medical Management of Endometriosis in Patients with Chronic Pelvic Pain. Semin Reprod Med. 2017;35(1):38-53.
Bedaiwy, M. A., Allaire, C., Yong, P., & Alfaraj, S. (2017). Medical Management of Endometriosis in Patients with Chronic Pelvic Pain. Seminars in Reproductive Medicine, 35(1), 38-53. https://doi.org/10.1055/s-0036-1597308
Bedaiwy MA, et al. Medical Management of Endometriosis in Patients With Chronic Pelvic Pain. Semin Reprod Med. 2017;35(1):38-53. PubMed PMID: 28002850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medical Management of Endometriosis in Patients with Chronic Pelvic Pain. AU - Bedaiwy,Mohamed A, AU - Allaire,Catherine, AU - Yong,Paul, AU - Alfaraj,Sukinah, Y1 - 2016/12/21/ PY - 2016/12/22/pubmed PY - 2017/11/8/medline PY - 2016/12/22/entrez SP - 38 EP - 53 JF - Seminars in reproductive medicine JO - Semin Reprod Med VL - 35 IS - 1 N2 - Endometriosis is a common cause of pelvic pain in women of reproductive age. Traditional medical therapies are hormonal in nature, including estrogen-progestin contraceptives, progestins, and gonadotropin-releasing hormone (GnRH) agonists. Other hormonal options are androgens and aromatase inhibitors, with research also suggesting a possible role for GnRH antagonists and selective progesterone receptor modulators. Other than nonsteroidal anti-inflammatories, further work is required for nonhormonal therapies such as antiangiogenic and immune-modulating drugs. Medical treatment of endometriosis can be complex, and requires consideration of side effects, the anatomic type of endometriosis, role of surgery, current infertility or future fertility desires, and other contributors to pain (e.g., central sensitization). These factors should be discussed for each patient, to ensure personalized treatment and optimal outcomes. SN - 1526-4564 UR - https://www.unboundmedicine.com/medline/citation/28002850/full_citation L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0036-1597308 DB - PRIME DP - Unbound Medicine ER -