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The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes.

Abstract

INTRODUCTION

Irritable bowel syndrome (IBS) and celiac disease (CD) share some gastrointestinal symptoms. Celiac disease should be considered in a differential diagnosis of IBS.

AIM

To estimate the prevalence of predispositions to CD in patients with IBS and its subtypes.

MATERIAL AND METHODS

The study included 48 patients (40 women, 8 men; average age: 41.1 ±14.6 years) with IBS, and a control group: 20 healthy volunteers. All participants completed a questionnaire on their current gastrointestinal symptoms and had a blood sample taken to determine the HLA-DQ2/DQ8 antigens and serum concentration of anti-tTG IgA and anti-DGP IgA and IgG.

RESULTS

The presence of HLA-DQ2 or DQ8 was found in 50% of patients (n = 24) with IBS. In the control group the presence of HLA-DQ2 was found in 4 (20%) patients and nobody had HLA-DQ8. Increased levels of anti-tTG IgA were found in 5 (10.42%) patients with IBS, anti-DGP in 4 (8.33%), and anti-DGP IgG in 3 (6.25%). In the control group positive test result for anti-tTG was found in 2 (10%) patients; nobody had elevated anti-DGP IgA or IgG. A concomitant positive result of genetic testing and any elevated serum antibodies specific to CD was found in 12.5% of IBS patients (n = 6) and in none of the control group.

CONCLUSIONS

Patients with IBS, regardless of the subtype, significantly more often than healthy controls have the predisposing genetic factors (HLA-DQ2/DQ8) underlying the development of CD.

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  • Authors+Show Affiliations

    ,

    Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.

    ,

    Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.

    ,

    Department of Biopharmacy, Medical University of Lodz, Lodz, Poland.

    ,

    Department of Biopharmacy, Medical University of Lodz, Lodz, Poland.

    ,

    Department of Biopharmacy, Medical University of Lodz, Lodz, Poland.

    Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.

    Source

    Przeglad gastroenterologiczny 11:4 2016 pg 276-281

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28053683

    Citation

    Domżał-Magrowska, Danuta, et al. "The Prevalence of Celiac Disease in Patients With Irritable Bowel Syndrome and Its Subtypes." Przeglad Gastroenterologiczny, vol. 11, no. 4, 2016, pp. 276-281.
    Domżał-Magrowska D, Kowalski MK, Szcześniak P, et al. The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes. Prz Gastroenterol. 2016;11(4):276-281.
    Domżał-Magrowska, D., Kowalski, M. K., Szcześniak, P., Bulska, M., Orszulak-Michalak, D., & Małecka-Panas, E. (2016). The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes. Przeglad Gastroenterologiczny, 11(4), pp. 276-281. doi:10.5114/pg.2016.57941.
    Domżał-Magrowska D, et al. The Prevalence of Celiac Disease in Patients With Irritable Bowel Syndrome and Its Subtypes. Prz Gastroenterol. 2016;11(4):276-281. PubMed PMID: 28053683.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes. AU - Domżał-Magrowska,Danuta, AU - Kowalski,Marek K, AU - Szcześniak,Piotr, AU - Bulska,Magdalena, AU - Orszulak-Michalak,Daria, AU - Małecka-Panas,Ewa, Y1 - 2016/02/16/ PY - 2015/04/20/received PY - 2015/06/22/accepted PY - 2017/1/6/entrez PY - 2017/1/6/pubmed PY - 2017/1/6/medline KW - HLA-DQ2/DQ8 KW - anti-DGP KW - anti-tTG KW - celiac disease KW - irritable bowel syndrome SP - 276 EP - 281 JF - Przeglad gastroenterologiczny JO - Prz Gastroenterol VL - 11 IS - 4 N2 - INTRODUCTION: Irritable bowel syndrome (IBS) and celiac disease (CD) share some gastrointestinal symptoms. Celiac disease should be considered in a differential diagnosis of IBS. AIM: To estimate the prevalence of predispositions to CD in patients with IBS and its subtypes. MATERIAL AND METHODS: The study included 48 patients (40 women, 8 men; average age: 41.1 ±14.6 years) with IBS, and a control group: 20 healthy volunteers. All participants completed a questionnaire on their current gastrointestinal symptoms and had a blood sample taken to determine the HLA-DQ2/DQ8 antigens and serum concentration of anti-tTG IgA and anti-DGP IgA and IgG. RESULTS: The presence of HLA-DQ2 or DQ8 was found in 50% of patients (n = 24) with IBS. In the control group the presence of HLA-DQ2 was found in 4 (20%) patients and nobody had HLA-DQ8. Increased levels of anti-tTG IgA were found in 5 (10.42%) patients with IBS, anti-DGP in 4 (8.33%), and anti-DGP IgG in 3 (6.25%). In the control group positive test result for anti-tTG was found in 2 (10%) patients; nobody had elevated anti-DGP IgA or IgG. A concomitant positive result of genetic testing and any elevated serum antibodies specific to CD was found in 12.5% of IBS patients (n = 6) and in none of the control group. CONCLUSIONS: Patients with IBS, regardless of the subtype, significantly more often than healthy controls have the predisposing genetic factors (HLA-DQ2/DQ8) underlying the development of CD. SN - 1895-5770 UR - https://www.unboundmedicine.com/medline/citation/28053683/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28053683/ DB - PRIME DP - Unbound Medicine ER -