Tags

Type your tag names separated by a space and hit enter

Prevalence of Metabolic Syndrome in Patients with Schizophrenia in Korea: A Multicenter Nationwide Cross-Sectional Study.

Abstract

OBJECTIVE

We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications.

METHODS

This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013. MetS was diagnosed using the criteria of the modified Adult Treatment Panel III of the National Cholesterol Education Program with the Korean abdominal obesity definition (waist circumference ≥85 cm in women, ≥90 cm in men).

RESULTS

The prevalence of MetS in all patients was 36.5% and was significantly higher in men than women (men, 40.8%; women, 32.2%) and was significantly correlated with age [odds ratio (OR) 1.02] and duration of illness (OR 1.03). The prevalence of MetS across antipsychotic drugs in the major monotherapy group was as follows: 18.8% for quetiapine, 22.0% for aripiprazole, 33.3% for both amisulpride and paliperidone, 34.0% for olanzapine, 35% for risperidone, 39.4% for haloperidol, and 44.7% for clozapine.

CONCLUSION

The prevalence of MetS is very high in patients with schizophrenia or schizoaffective disorder. Screening and monitoring of MetS is also strongly recommended.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

    ,

    Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

    ,

    Department of Psychiatry, College of Medicine, Hanyang University, Hanyang University Medical Center, Seoul, Republic of Korea.

    ,

    Department of Psychiatry, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Republic of Korea.

    ,

    Department of Psychiatry, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea.

    ,

    Department of Psychiatry, Gil Medical Center, Gachon University School of Medicine, Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea.

    ,

    Department of Psychiatry, Seoul Medical Center, Seoul, Republic of Korea.

    ,

    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea.

    ,

    Department of Psychiatry & Behavioral Neuroscience, Catholic Kwandong University, International St. Mary's Hospital, Incheon, Republic of Korea.

    ,

    Department of Psychiatry, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea.

    ,

    Yongin Psychiatric Research Institute, Yongin Mental Hospital, Yongin, Republic of Korea.

    ,

    Department of Psychiatry, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.

    ,

    Department of Psychiatry, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea.

    ,

    Department of Psychiatry, Eulji University School of Medicine, Eulji General Hospital, Seoul, Republic of Korea.

    ,

    Department of Psychiatry, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Republic of Korea.

    ,

    Yongin Psychiatric Research Institute, Yongin Mental Hospital, Yongin, Republic of Korea.

    ,

    Department of Psychiatry, College of Medicine, Hallym University, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea.

    ,

    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea.

    Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

    Source

    Psychiatry investigation 14:1 2017 Jan pg 44-50

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28096874

    Citation

    Lee, Jung Sun, et al. "Prevalence of Metabolic Syndrome in Patients With Schizophrenia in Korea: a Multicenter Nationwide Cross-Sectional Study." Psychiatry Investigation, vol. 14, no. 1, 2017, pp. 44-50.
    Lee JS, Kwon JS, Kim D, et al. Prevalence of Metabolic Syndrome in Patients with Schizophrenia in Korea: A Multicenter Nationwide Cross-Sectional Study. Psychiatry Investig. 2017;14(1):44-50.
    Lee, J. S., Kwon, J. S., Kim, D., Kim, S. W., Kim, J. J., Kim, J. H., ... Joo, Y. H. (2017). Prevalence of Metabolic Syndrome in Patients with Schizophrenia in Korea: A Multicenter Nationwide Cross-Sectional Study. Psychiatry Investigation, 14(1), pp. 44-50. doi:10.4306/pi.2017.14.1.44.
    Lee JS, et al. Prevalence of Metabolic Syndrome in Patients With Schizophrenia in Korea: a Multicenter Nationwide Cross-Sectional Study. Psychiatry Investig. 2017;14(1):44-50. PubMed PMID: 28096874.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence of Metabolic Syndrome in Patients with Schizophrenia in Korea: A Multicenter Nationwide Cross-Sectional Study. AU - Lee,Jung Sun, AU - Kwon,Jun Soo, AU - Kim,Daeho, AU - Kim,Sung-Wan, AU - Kim,Jae-Jin, AU - Kim,Jong-Hoon, AU - Nam,Hee Jung, AU - Ryu,Seunghyong, AU - Park,Il Ho, AU - An,Suk Kyoon, AU - Oh,Hong-Seok, AU - Won,Seunghee, AU - Lee,Kanguk, AU - Lee,Kyu Young, AU - Lee,Seung-Hwan, AU - Lee,Yu Sang, AU - Yi,Jung-Seo, AU - Hong,Kyung Sue, AU - Joo,Yeon Ho, Y1 - 2016/12/29/ PY - 2016/02/19/received PY - 2016/05/02/revised PY - 2016/06/03/accepted PY - 2017/1/19/entrez PY - 2017/1/18/pubmed PY - 2017/1/18/medline KW - Antipsychotics KW - Korean population KW - Metabolic syndrome KW - Schizoaffective disorder KW - Schizophrenia SP - 44 EP - 50 JF - Psychiatry investigation JO - Psychiatry Investig VL - 14 IS - 1 N2 - OBJECTIVE: We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. METHODS: This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013. MetS was diagnosed using the criteria of the modified Adult Treatment Panel III of the National Cholesterol Education Program with the Korean abdominal obesity definition (waist circumference ≥85 cm in women, ≥90 cm in men). RESULTS: The prevalence of MetS in all patients was 36.5% and was significantly higher in men than women (men, 40.8%; women, 32.2%) and was significantly correlated with age [odds ratio (OR) 1.02] and duration of illness (OR 1.03). The prevalence of MetS across antipsychotic drugs in the major monotherapy group was as follows: 18.8% for quetiapine, 22.0% for aripiprazole, 33.3% for both amisulpride and paliperidone, 34.0% for olanzapine, 35% for risperidone, 39.4% for haloperidol, and 44.7% for clozapine. CONCLUSION: The prevalence of MetS is very high in patients with schizophrenia or schizoaffective disorder. Screening and monitoring of MetS is also strongly recommended. SN - 1738-3684 UR - https://www.unboundmedicine.com/medline/citation/28096874/full_citation L2 - http://psychiatryinvestigation.org/journal/view.php?doi=10.4306/pi.2017.14.1.44 DB - PRIME DP - Unbound Medicine ER -