Megaloblastic Anemias: Nutritional and Other Causes.
Med Clin North Am. 2017 Mar; 101(2):297-317.MC

Abstract

Vitamin B₁₂ and folate deficiencies are major causes of megaloblastic anemia. Causes of B₁₂ deficiency include pernicious anemia, gastric surgery, intestinal disorders, dietary deficiency, and inherited disorders of B₁₂ transport or absorption. The prevalence of folate deficiency has decreased because of folate fortification, but deficiency still occurs from malabsorption and increased demand. Other causes include drugs and inborn metabolic errors. Clinical features of megaloblastic anemia include anemia, cytopenias, jaundice, and megaloblastic marrow morphology. Neurologic symptoms occur in B₁₂ deficiency, but not in folate deficiency. Management includes identifying any deficiency, establishing its cause, and replenishing B₁₂ or folate parenterally or orally.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Green R

Department of Pathology and Laboratory Medicine, UC Davis Medical Center, University of California Davis Health System, 4400 V. Street, Sacramento, CA 95817, USA. Electronic address: rgreen@UCDAVIS.EDU.

Datta Mitra A

Department of Pathology and Laboratory Medicine, UC Davis Medical Center, University of California Davis Health System, 4400 V. Street, Sacramento, CA 95817, USA.

MeSH

Anemia, MegaloblasticComorbidityFolic Acid DeficiencyHumansMetabolic DiseasesNutrition DisordersPrevalenceVitamin B 12 Deficiency

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

28189172

Citation

Green, Ralph, and Ananya Datta Mitra. "Megaloblastic Anemias: Nutritional and Other Causes." The Medical Clinics of North America, vol. 101, no. 2, 2017, pp. 297-317.

Green R, Datta Mitra A. Megaloblastic Anemias: Nutritional and Other Causes. Med Clin North Am. 2017;101(2):297-317.

Green, R., & Datta Mitra, A. (2017). Megaloblastic Anemias: Nutritional and Other Causes. The Medical Clinics of North America, 101(2), 297-317. https://doi.org/10.1016/j.mcna.2016.09.013

Green R, Datta Mitra A. Megaloblastic Anemias: Nutritional and Other Causes. Med Clin North Am. 2017;101(2):297-317. PubMed PMID: 28189172.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Megaloblastic Anemias: Nutritional and Other Causes. AU - Green,Ralph, AU - Datta Mitra,Ananya, Y1 - 2016/12/14/ PY - 2017/2/13/entrez PY - 2017/2/13/pubmed PY - 2017/3/16/medline KW - Anemia KW - Folate KW - Homocysteine KW - Megaloblastic KW - Methylmalonic acid KW - Pernicious anemia KW - Transcobalamin KW - Vitamin B(12) SP - 297 EP - 317 JF - The Medical clinics of North America JO - Med Clin North Am VL - 101 IS - 2 N2 - Vitamin B12 and folate deficiencies are major causes of megaloblastic anemia. Causes of B12 deficiency include pernicious anemia, gastric surgery, intestinal disorders, dietary deficiency, and inherited disorders of B12 transport or absorption. The prevalence of folate deficiency has decreased because of folate fortification, but deficiency still occurs from malabsorption and increased demand. Other causes include drugs and inborn metabolic errors. Clinical features of megaloblastic anemia include anemia, cytopenias, jaundice, and megaloblastic marrow morphology. Neurologic symptoms occur in B12 deficiency, but not in folate deficiency. Management includes identifying any deficiency, establishing its cause, and replenishing B12 or folate parenterally or orally. SN - 1557-9859 UR - https://www.unboundmedicine.com/medline/citation/28189172/full_citation DB - PRIME DP - Unbound Medicine ER -

Tags

Megaloblastic Anemias: Nutritional and Other Causes.Med Clin North Am. 2017 Mar; 101(2):297-317.MC