Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts.
Diabetes Care. 2017 Jul; 40(7):920-927.DC

Abstract

OBJECTIVE

Our aim was to study the relation between the duration of full and any breastfeeding and risk of type 1 diabetes.

RESEARCH DESIGN AND METHODS

We included two population-based cohorts of children followed from birth (1996-2009) to 2014 (Denmark) or 2015 (Norway). We analyzed data from a total of 155,392 children participating in the Norwegian Mother and Child Cohort Study (MoBa) and the Danish National Birth Cohort (DNBC). Parents reported infant dietary practices when their child was 6 and 18 months old. The outcome was clinical type 1 diabetes, ascertained from nationwide childhood diabetes registries. Hazard ratios (HRs) were estimated using Cox regression.

RESULTS

Type 1 diabetes was identified in 504 children during follow-up, and the incidence of type 1 diabetes per 100,000 person-years was 30.5 in the Norwegian cohort and 23.5 in the Danish cohort. Children who were never breastfed had a twofold increased risk of type 1 diabetes compared with those who were breastfed (HR 2.29 [95% CI 1.14-4.61] for no breastfeeding vs. any breastfeeding for ≥12 months). Among those who were breastfed, however, the incidence of type 1 diabetes was independent of duration of both full breastfeeding (HR per month 0.99 [95% CI 0.97-1.01]) and any breastfeeding (0.97 [0.92-1.03]).

CONCLUSIONS

Suggestive evidence supports the contention that breastfeeding reduces the risk of type 1 diabetes. Among those who were breastfed, however, no evidence indicated that prolonging full or any breastfeeding was associated with a reduced risk of type 1 diabetes.

Links

Authors+Show Affiliations

Lund-Blix NA

Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway nicolai.andre.lund-blix@fhi.no. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.

Dydensborg Sander S

Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.

Størdal K

Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.

Nybo Andersen AM

Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Rønningen KS

Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Joner G

Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.

Skrivarhaug T

Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.

Njølstad PR

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.

Husby S

Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.

Stene LC

Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.

MeSH

AdultBreast FeedingCohort StudiesDiabetes Mellitus, Type 1DietEuropean Continental Ancestry GroupFemaleHumansIncidenceInfantMaleNutrition AssessmentProportional Hazards ModelsRegistriesRisk FactorsScandinavian and Nordic CountriesSocioeconomic FactorsSurveys and Questionnaires

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28487451

Citation

Lund-Blix, Nicolai A., et al. "Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts." Diabetes Care, vol. 40, no. 7, 2017, pp. 920-927.

Lund-Blix NA, Dydensborg Sander S, Størdal K, et al. Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts. Diabetes Care. 2017;40(7):920-927.

Lund-Blix, N. A., Dydensborg Sander, S., Størdal, K., Nybo Andersen, A. M., Rønningen, K. S., Joner, G., Skrivarhaug, T., Njølstad, P. R., Husby, S., & Stene, L. C. (2017). Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts. Diabetes Care, 40(7), 920-927. https://doi.org/10.2337/dc17-0016

Lund-Blix NA, et al. Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts. Diabetes Care. 2017;40(7):920-927. PubMed PMID: 28487451.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts. AU - Lund-Blix,Nicolai A, AU - Dydensborg Sander,Stine, AU - Størdal,Ketil, AU - Nybo Andersen,Anne-Marie, AU - Rønningen,Kjersti S, AU - Joner,Geir, AU - Skrivarhaug,Torild, AU - Njølstad,Pål R, AU - Husby,Steffen, AU - Stene,Lars C, Y1 - 2017/05/09/ PY - 2017/01/03/received PY - 2017/04/11/accepted PY - 2017/5/11/pubmed PY - 2017/12/29/medline PY - 2017/5/11/entrez SP - 920 EP - 927 JF - Diabetes care JO - Diabetes Care VL - 40 IS - 7 N2 - OBJECTIVE: Our aim was to study the relation between the duration of full and any breastfeeding and risk of type 1 diabetes. RESEARCH DESIGN AND METHODS: We included two population-based cohorts of children followed from birth (1996-2009) to 2014 (Denmark) or 2015 (Norway). We analyzed data from a total of 155,392 children participating in the Norwegian Mother and Child Cohort Study (MoBa) and the Danish National Birth Cohort (DNBC). Parents reported infant dietary practices when their child was 6 and 18 months old. The outcome was clinical type 1 diabetes, ascertained from nationwide childhood diabetes registries. Hazard ratios (HRs) were estimated using Cox regression. RESULTS: Type 1 diabetes was identified in 504 children during follow-up, and the incidence of type 1 diabetes per 100,000 person-years was 30.5 in the Norwegian cohort and 23.5 in the Danish cohort. Children who were never breastfed had a twofold increased risk of type 1 diabetes compared with those who were breastfed (HR 2.29 [95% CI 1.14-4.61] for no breastfeeding vs. any breastfeeding for ≥12 months). Among those who were breastfed, however, the incidence of type 1 diabetes was independent of duration of both full breastfeeding (HR per month 0.99 [95% CI 0.97-1.01]) and any breastfeeding (0.97 [0.92-1.03]). CONCLUSIONS: Suggestive evidence supports the contention that breastfeeding reduces the risk of type 1 diabetes. Among those who were breastfed, however, no evidence indicated that prolonging full or any breastfeeding was associated with a reduced risk of type 1 diabetes. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/28487451/full_citation L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=28487451 DB - PRIME DP - Unbound Medicine ER -

Tags

Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts.Diabetes Care. 2017 Jul; 40(7):920-927.DC