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The sleep-deprived human brain.
Nat Rev Neurosci. 2017 Jul; 18(7):404-418.NR

Abstract

How does a lack of sleep affect our brains? In contrast to the benefits of sleep, frameworks exploring the impact of sleep loss are relatively lacking. Importantly, the effects of sleep deprivation (SD) do not simply reflect the absence of sleep and the benefits attributed to it; rather, they reflect the consequences of several additional factors, including extended wakefulness. With a focus on neuroimaging studies, we review the consequences of SD on attention and working memory, positive and negative emotion, and hippocampal learning. We explore how this evidence informs our mechanistic understanding of the known changes in cognition and emotion associated with SD, and the insights it provides regarding clinical conditions associated with sleep disruption.

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Authors+Show Affiliations

Krause AJ
Department of Psychology, University of California, Berkeley.
Simon EB
Department of Psychology, University of California, Berkeley.
Mander BA
Department of Psychology, University of California, Berkeley.
Greer SM
Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720-1650, USA.
Saletin JM
Department of Psychology, University of California, Berkeley.
Goldstein-Piekarski AN
Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720-1650, USA.
Walker MP
Department of Psychology, University of California, Berkeley. Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720-1650, USA.

MeSH

AttentionBrainCognitionEmotionsHippocampusHumansMemory, Short-TermNeuroimagingRewardSleep DeprivationWakefulness

Pub Type(s)

Journal Article
Review
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28515433

Clinical Trial Links

Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators

Citation

Krause, Adam J., et al. "The Sleep-deprived Human Brain." Nature Reviews. Neuroscience, vol. 18, no. 7, 2017, pp. 404-418.
Krause AJ, Simon EB, Mander BA, et al. The sleep-deprived human brain. Nat Rev Neurosci. 2017;18(7):404-418.
Krause, A. J., Simon, E. B., Mander, B. A., Greer, S. M., Saletin, J. M., Goldstein-Piekarski, A. N., & Walker, M. P. (2017). The sleep-deprived human brain. Nature Reviews. Neuroscience, 18(7), 404-418. https://doi.org/10.1038/nrn.2017.55
Krause AJ, et al. The Sleep-deprived Human Brain. Nat Rev Neurosci. 2017;18(7):404-418. PubMed PMID: 28515433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The sleep-deprived human brain. AU - Krause,Adam J, AU - Simon,Eti Ben, AU - Mander,Bryce A, AU - Greer,Stephanie M, AU - Saletin,Jared M, AU - Goldstein-Piekarski,Andrea N, AU - Walker,Matthew P, Y1 - 2017/05/18/ PY - 2017/5/19/pubmed PY - 2017/8/8/medline PY - 2017/5/19/entrez SP - 404 EP - 418 JF - Nature reviews. Neuroscience JO - Nat Rev Neurosci VL - 18 IS - 7 N2 - How does a lack of sleep affect our brains? In contrast to the benefits of sleep, frameworks exploring the impact of sleep loss are relatively lacking. Importantly, the effects of sleep deprivation (SD) do not simply reflect the absence of sleep and the benefits attributed to it; rather, they reflect the consequences of several additional factors, including extended wakefulness. With a focus on neuroimaging studies, we review the consequences of SD on attention and working memory, positive and negative emotion, and hippocampal learning. We explore how this evidence informs our mechanistic understanding of the known changes in cognition and emotion associated with SD, and the insights it provides regarding clinical conditions associated with sleep disruption. SN - 1471-0048 UR - https://www.unboundmedicine.com/medline/citation/28515433/The_sleep-deprived_human_brain L2 - https://doi.org/10.1038/nrn.2017.55 DB - PRIME DP - Unbound Medicine ER -
High [↓523 ↑178]

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