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Genetic polymorphisms and folate status.
Congenit Anom (Kyoto). 2017 Sep; 57(5):142-149.CA

Abstract

Moderate hyperhomocysteinemia-induced low folate status is an independent risk factor for cardiovascular disease, dementia, and depression. Folate is an essential cofactor in the one-carbon metabolism pathway and is necessary in amino acid metabolism, purine and thymidylate synthesis, and DNA methylation. In the folate cycle and homocysteine metabolism, folate, vitamin B12, vitamin B6, and vitamin B2 are important cofactors. Many enzymes are involved in folate transport and uptake, the folate pathway, and homocysteine (Hcy) metabolism, and various polymorphisms have been documented in these enzymes. Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T. The prevalence of the MTHFR 677TT genotype varies across ethnic groups and regions, with a frequency of approximately 15% in Japanese populations. Individuals with the TT genotype have significantly higher tHcy levels and lower folate levels in serum than those with the CT and TT genotypes. However, administration of folic acid has been shown to eliminate these differences. Moreover, data have suggested that interventions based on genotype may be effective for motivating individuals to change their lifestyle and improve their nutrition status. Accordingly, in this review, we discuss the effects of MTHFR C677T polymorphisms on serum tHcy and folate levels with folic acid intervention and evaluate approaches for overcoming folic acid deficiency and related symptoms.

Authors+Show Affiliations

College of Nursing and Nutrition, School of Nutrition, Shukutoku University, Chiba City, Chiba, Japan.Department of Medical Chemistry, Kagawa Nutrition University, Sakado City, Saitama, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28598562

Citation

Hiraoka, Mami, and Yasuo Kagawa. "Genetic Polymorphisms and Folate Status." Congenital Anomalies, vol. 57, no. 5, 2017, pp. 142-149.
Hiraoka M, Kagawa Y. Genetic polymorphisms and folate status. Congenit Anom (Kyoto). 2017;57(5):142-149.
Hiraoka, M., & Kagawa, Y. (2017). Genetic polymorphisms and folate status. Congenital Anomalies, 57(5), 142-149. https://doi.org/10.1111/cga.12232
Hiraoka M, Kagawa Y. Genetic Polymorphisms and Folate Status. Congenit Anom (Kyoto). 2017;57(5):142-149. PubMed PMID: 28598562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic polymorphisms and folate status. AU - Hiraoka,Mami, AU - Kagawa,Yasuo, Y1 - 2017/07/20/ PY - 2017/02/23/received PY - 2017/05/23/revised PY - 2017/06/04/accepted PY - 2017/6/10/pubmed PY - 2018/8/31/medline PY - 2017/6/10/entrez KW - folate KW - methylenetetrahydrofolate reductase KW - personalized nutrition KW - polymorphism SP - 142 EP - 149 JF - Congenital anomalies JO - Congenit Anom (Kyoto) VL - 57 IS - 5 N2 - Moderate hyperhomocysteinemia-induced low folate status is an independent risk factor for cardiovascular disease, dementia, and depression. Folate is an essential cofactor in the one-carbon metabolism pathway and is necessary in amino acid metabolism, purine and thymidylate synthesis, and DNA methylation. In the folate cycle and homocysteine metabolism, folate, vitamin B12, vitamin B6, and vitamin B2 are important cofactors. Many enzymes are involved in folate transport and uptake, the folate pathway, and homocysteine (Hcy) metabolism, and various polymorphisms have been documented in these enzymes. Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T. The prevalence of the MTHFR 677TT genotype varies across ethnic groups and regions, with a frequency of approximately 15% in Japanese populations. Individuals with the TT genotype have significantly higher tHcy levels and lower folate levels in serum than those with the CT and TT genotypes. However, administration of folic acid has been shown to eliminate these differences. Moreover, data have suggested that interventions based on genotype may be effective for motivating individuals to change their lifestyle and improve their nutrition status. Accordingly, in this review, we discuss the effects of MTHFR C677T polymorphisms on serum tHcy and folate levels with folic acid intervention and evaluate approaches for overcoming folic acid deficiency and related symptoms. SN - 1741-4520 UR - https://www.unboundmedicine.com/medline/citation/28598562/full_citation L2 - https://doi.org/10.1111/cga.12232 DB - PRIME DP - Unbound Medicine ER -