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Dietary Factors Associated with Plasma Thyroid Peroxidase and Thyroglobulin Antibodies.
Nutrients. 2017 Oct 28; 9(11)N

Abstract

The knowledge about dietary habits and their influence in the development of autoimmune thyroid disease is insufficient. The aim of this study was to analyse the association of dietary factors and plasma thyroid peroxidase antibodies (TPO-Ab) and/or thyroglobulin antibodies (Tg-Ab). The study enrolled 1887 participants originating from the South Croatia. Participants with elevated plasma TPO-Ab and/or Tg-Ab were defined as cases (n = 462) and those with TPO-Ab and/or Tg-Ab within referent values were defined as controls (n = 1425). Dietary intake was evaluated according to a food frequency questionnaire containing 58 food items. Principal component analysis was used to group food items into dietary groups. We used logistic regression analysis to examine dietary groups associated with positive plasma TPO-Ab and/or Tg-Ab. The results indicate that the dietary group with frequent consumption of animal fats and butter is associated with positive plasma TPO-Ab and/or Tg-Ab (p = 0.01). The dietary group with frequent consumption of vegetables as well as the dietary group with high consumption of dried fruit, nuts, and muesli are associated with negative findings of TPO-Ab and/or Tg-Ab (p = 0.048 and p = 0.02, respectively). We showed that the anti-inflammatory dietary groups are associated with the negative findings of plasma TPO-Ab and/or Tg-Ab.

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Authors+Show Affiliations

Matana A
Department of Medical Biology, School of Medicine Split, University of Split, Šoltanska 2, 21000 Split, Croatia. antonela.boljat@mefst.hr.
Torlak V
Department of Nuclear Medicine, University Hospital Split, Spinciceva 1, 21000 Split, Croatia. veselakbsplit@yahoo.com.
Brdar D
Department of Nuclear Medicine, University Hospital Split, Spinciceva 1, 21000 Split, Croatia. d.brdar.dr@gmail.com.
Popović M
Department of Medical Biology, School of Medicine Split, University of Split, Šoltanska 2, 21000 Split, Croatia. mpopovic@mefst.hr.
Lozić B
Department of Pediatrics, University Hospital Split, Spinciceva 1, 21000 Split, Croatia. blozic@kbsplit.hr.
Barbalić M
Department of Medical Biology, School of Medicine Split, University of Split, Šoltanska 2, 21000 Split, Croatia. mbarbali@mefst.hr.
Perica VB
Department of Medical Biology, School of Medicine Split, University of Split, Šoltanska 2, 21000 Split, Croatia. vesna.boraska@mefst.hr.
Punda A
Department of Nuclear Medicine, University Hospital Split, Spinciceva 1, 21000 Split, Croatia. ante.punda@mefst.hr.
Polašek O
Department of Public Health, School of Medicine Split, University of Split, Šoltanska 2 , 21000 Split, Croatia. opolasek@gmail.com.
Hayward C
MRC Human Genetics Unit, University of Edinburgh, Western General Hospital, Crewe Road, EH4 2XU Edinburgh, UK. caroline.hayward@igmm.ed.ac.uk.
Zemunik T
Department of Medical Biology, School of Medicine Split, University of Split, Šoltanska 2, 21000 Split, Croatia. tzemunik@mefst.hr.

MeSH

AdultAgedAutoantibodiesAutoantigensAutoimmune DiseasesBiomarkersCase-Control StudiesChi-Square DistributionCroatiaCross-Sectional StudiesDietFeeding BehaviorFemaleHumansIodide PeroxidaseIron-Binding ProteinsLogistic ModelsMaleMiddle AgedOdds RatioPrincipal Component AnalysisProtective FactorsRisk FactorsThyroglobulinThyroid DiseasesUp-Regulation

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29143786

Citation

Matana, Antonela, et al. "Dietary Factors Associated With Plasma Thyroid Peroxidase and Thyroglobulin Antibodies." Nutrients, vol. 9, no. 11, 2017.
Matana A, Torlak V, Brdar D, et al. Dietary Factors Associated with Plasma Thyroid Peroxidase and Thyroglobulin Antibodies. Nutrients. 2017;9(11).
Matana, A., Torlak, V., Brdar, D., Popović, M., Lozić, B., Barbalić, M., Perica, V. B., Punda, A., Polašek, O., Hayward, C., & Zemunik, T. (2017). Dietary Factors Associated with Plasma Thyroid Peroxidase and Thyroglobulin Antibodies. Nutrients, 9(11). https://doi.org/10.3390/nu9111186
Matana A, et al. Dietary Factors Associated With Plasma Thyroid Peroxidase and Thyroglobulin Antibodies. Nutrients. 2017 Oct 28;9(11) PubMed PMID: 29143786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Factors Associated with Plasma Thyroid Peroxidase and Thyroglobulin Antibodies. AU - Matana,Antonela, AU - Torlak,Vesela, AU - Brdar,Dubravka, AU - Popović,Marijana, AU - Lozić,Bernarda, AU - Barbalić,Maja, AU - Perica,Vesna Boraska, AU - Punda,Ante, AU - Polašek,Ozren, AU - Hayward,Caroline, AU - Zemunik,Tatijana, Y1 - 2017/10/28/ PY - 2017/10/12/received PY - 2017/10/20/revised PY - 2017/10/25/accepted PY - 2017/11/17/entrez PY - 2017/11/17/pubmed PY - 2018/7/10/medline KW - autoimmune thyroid diseases KW - dietary habits KW - thyroglobulin antibodies KW - thyroid peroxidase antibodies JF - Nutrients JO - Nutrients VL - 9 IS - 11 N2 - The knowledge about dietary habits and their influence in the development of autoimmune thyroid disease is insufficient. The aim of this study was to analyse the association of dietary factors and plasma thyroid peroxidase antibodies (TPO-Ab) and/or thyroglobulin antibodies (Tg-Ab). The study enrolled 1887 participants originating from the South Croatia. Participants with elevated plasma TPO-Ab and/or Tg-Ab were defined as cases (n = 462) and those with TPO-Ab and/or Tg-Ab within referent values were defined as controls (n = 1425). Dietary intake was evaluated according to a food frequency questionnaire containing 58 food items. Principal component analysis was used to group food items into dietary groups. We used logistic regression analysis to examine dietary groups associated with positive plasma TPO-Ab and/or Tg-Ab. The results indicate that the dietary group with frequent consumption of animal fats and butter is associated with positive plasma TPO-Ab and/or Tg-Ab (p = 0.01). The dietary group with frequent consumption of vegetables as well as the dietary group with high consumption of dried fruit, nuts, and muesli are associated with negative findings of TPO-Ab and/or Tg-Ab (p = 0.048 and p = 0.02, respectively). We showed that the anti-inflammatory dietary groups are associated with the negative findings of plasma TPO-Ab and/or Tg-Ab. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/29143786/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓15 ↑36]

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