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Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial.
Pediatr Infect Dis J. 2018 08; 37(8):749-754.PI

Abstract

OBJECTIVES

This study aimed to evaluate the clinical efficacy and safety of vitamin D for preventing influenza A in 400 infants in a multicenter, randomized, open, controlled clinical trial.

METHODS

The infants were randomized into low-dose and high-dose vitamin D groups, and serum calcium, inorganic phosphorus and 25-hydroxyvitamin D levels were detected thrice in 4 months. Infants infected with influenza A were monitored for symptoms including fever, cough and wheezing. Pathogen levels and safety of vitamin D treatment were also evaluated.

RESULTS

Of 121 cases in total, 78 and 43 cases of influenza A infection occurred in the low-dose and high-dose vitamin D groups, respectively. There was a significant difference between the groups (χ = 14.6324, P = 0.0001). Among the cases of influenza infection, the median durations for fever, cough and wheezing were shorter in the high-dose vitamin D group than in the low-dose vitamin D group. The viral loads showed a downward trend in both groups and were significantly different between the groups at the second and third detections. Additionally, the incidences of adverse events and severe adverse events were very low and not significantly different between the 2 groups.

CONCLUSION

High-dose vitamin D (1200 IU) is suitable for the prevention of seasonal influenza as evidenced by rapid relief from symptoms, rapid decrease in viral loads and disease recovery. In addition, high-dose vitamin D is probably safe for infants.

Authors+Show Affiliations

From the Department of Pediatrics, The First People's Hospital of Yongkang, Yongkang, China.From the Department of Pediatrics, The First People's Hospital of Yongkang, Yongkang, China.Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.Department of Pediatrics, Jinhua People's Hospital, Jinhua, China.Department of Pediatrics, Jinhua People's Hospital, Jinhua, China.Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29315160

Citation

Zhou, Jian, et al. "Preventive Effects of Vitamin D On Seasonal Influenza a in Infants: a Multicenter, Randomized, Open, Controlled Clinical Trial." The Pediatric Infectious Disease Journal, vol. 37, no. 8, 2018, pp. 749-754.
Zhou J, Du J, Huang L, et al. Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial. Pediatr Infect Dis J. 2018;37(8):749-754.
Zhou, J., Du, J., Huang, L., Wang, Y., Shi, Y., & Lin, H. (2018). Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial. The Pediatric Infectious Disease Journal, 37(8), 749-754. https://doi.org/10.1097/INF.0000000000001890
Zhou J, et al. Preventive Effects of Vitamin D On Seasonal Influenza a in Infants: a Multicenter, Randomized, Open, Controlled Clinical Trial. Pediatr Infect Dis J. 2018;37(8):749-754. PubMed PMID: 29315160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial. AU - Zhou,Jian, AU - Du,Juan, AU - Huang,Leting, AU - Wang,Youcheng, AU - Shi,Yimei, AU - Lin,Hailong, PY - 2018/1/10/pubmed PY - 2019/5/10/medline PY - 2018/1/10/entrez SP - 749 EP - 754 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 37 IS - 8 N2 - OBJECTIVES: This study aimed to evaluate the clinical efficacy and safety of vitamin D for preventing influenza A in 400 infants in a multicenter, randomized, open, controlled clinical trial. METHODS: The infants were randomized into low-dose and high-dose vitamin D groups, and serum calcium, inorganic phosphorus and 25-hydroxyvitamin D levels were detected thrice in 4 months. Infants infected with influenza A were monitored for symptoms including fever, cough and wheezing. Pathogen levels and safety of vitamin D treatment were also evaluated. RESULTS: Of 121 cases in total, 78 and 43 cases of influenza A infection occurred in the low-dose and high-dose vitamin D groups, respectively. There was a significant difference between the groups (χ = 14.6324, P = 0.0001). Among the cases of influenza infection, the median durations for fever, cough and wheezing were shorter in the high-dose vitamin D group than in the low-dose vitamin D group. The viral loads showed a downward trend in both groups and were significantly different between the groups at the second and third detections. Additionally, the incidences of adverse events and severe adverse events were very low and not significantly different between the 2 groups. CONCLUSION: High-dose vitamin D (1200 IU) is suitable for the prevention of seasonal influenza as evidenced by rapid relief from symptoms, rapid decrease in viral loads and disease recovery. In addition, high-dose vitamin D is probably safe for infants. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/29315160/full_citation L2 - https://doi.org/10.1097/INF.0000000000001890 DB - PRIME DP - Unbound Medicine ER -