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Sickle Cell Disease
StatPearls. StatPearls Publishing: Treasure Island (FL).BOOK

Abstract

Sickle cell disease (SCD) is a multisystem disorder and the most common genetic disease in the United States, affecting 1 in 500 African Americans. About 1 in 12 African Americans carry the autosomal recessive mutation, and approximately 300,000 infants are born with sickle cell anemia annually. The understanding of the phenotypic expression of the disease is still limited. However, environmental factors such as cold weather and air quality, infections, fetal hemoglobin level, and other genetic subtypes play a role in the manifestation of the disease. Clinical manifestations are variable and affect multiple systems, and generally cause lower life expectancy.[1][2][3]

Publisher

StatPearls Publishing
Treasure Island (FL)

Language

eng

PubMed ID

29494006

Citation

Sedrak A, Kondamudi NP: Sickle Cell Disease. StatPearls. StatPearls Publishing, 2021, Treasure Island (FL).
Sedrak A, Kondamudi NP. Sickle Cell Disease. StatPearls. StatPearls Publishing; 2021.
Sedrak A & Kondamudi NP. (2021). Sickle Cell Disease. In StatPearls. Treasure Island (FL): StatPearls Publishing
Sedrak A, Kondamudi NP. Sickle Cell Disease. StatPearls. Treasure Island (FL): StatPearls Publishing; 2021.
* Article titles in AMA citation format should be in sentence-case
TY - CHAP T1 - Sickle Cell Disease BT - StatPearls A1 - Sedrak,Aziza, AU - Kondamudi,Noah P., Y1 - 2021/01// PY - 2018/3/2/pubmed PY - 2018/3/2/medline PY - 2018/3/2/entrez N2 - Sickle cell disease (SCD) is a multisystem disorder and the most common genetic disease in the United States, affecting 1 in 500 African Americans. About 1 in 12 African Americans carry the autosomal recessive mutation, and approximately 300,000 infants are born with sickle cell anemia annually. The understanding of the phenotypic expression of the disease is still limited. However, environmental factors such as cold weather and air quality, infections, fetal hemoglobin level, and other genetic subtypes play a role in the manifestation of the disease. Clinical manifestations are variable and affect multiple systems, and generally cause lower life expectancy.[1][2][3] PB - StatPearls Publishing CY - Treasure Island (FL) UR - https://www.unboundmedicine.com/medline/citation/29494006/StatPearls L2 - https://www.ncbi.nlm.nih.gov/books/NBK482384 DB - PRIME DP - Unbound Medicine ER -
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