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Healing of benign gastric ulcer with low-dose antacids and fiber diet.

Abstract

A randomized, double-blind, placebo-controlled trial was conducted to determine the efficacy of a low-dose aluminum-magnesium antacid regimen (Link one tablet q.i.d.) (total neutralizing capacity 120 mmol HCl/day) in combination with a high- or a low-fiber diet in ulcer healing and relief of symptoms in patients with benign gastric ulcer. After 6 wk, the ulcer healed in 28 (67%) of the 42 patients treated with antacids compared with 11 (25%) of the 44 patients treated with placebo (p less than 0.001). Antacids were also significantly more effective than placebo in the relief of symptoms. The dietary treatment did not significantly influence ulcer healing or ulcer symptoms. Constipation was more frequently seen with the low- than with the high-fiber diet (p less than 0.01). No significant side effects from antacids were recorded.

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  • Publisher Full Text
  • Authors

    , , ,

    Source

    Gastroenterology 91:1 1986 Jul pg 56-61

    MeSH

    Adult
    Aged
    Antacids
    Clinical Trials as Topic
    Diet
    Dietary Fiber
    Double-Blind Method
    Female
    Humans
    Male
    Middle Aged
    Placebos
    Random Allocation
    Stomach Ulcer

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    3011583

    Citation

    Rydning, A, et al. "Healing of Benign Gastric Ulcer With Low-dose Antacids and Fiber Diet." Gastroenterology, vol. 91, no. 1, 1986, pp. 56-61.
    Rydning A, Weberg R, Lange O, et al. Healing of benign gastric ulcer with low-dose antacids and fiber diet. Gastroenterology. 1986;91(1):56-61.
    Rydning, A., Weberg, R., Lange, O., & Berstad, A. (1986). Healing of benign gastric ulcer with low-dose antacids and fiber diet. Gastroenterology, 91(1), pp. 56-61.
    Rydning A, et al. Healing of Benign Gastric Ulcer With Low-dose Antacids and Fiber Diet. Gastroenterology. 1986;91(1):56-61. PubMed PMID: 3011583.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Healing of benign gastric ulcer with low-dose antacids and fiber diet. AU - Rydning,A, AU - Weberg,R, AU - Lange,O, AU - Berstad,A, PY - 1986/7/1/pubmed PY - 1986/7/1/medline PY - 1986/7/1/entrez SP - 56 EP - 61 JF - Gastroenterology JO - Gastroenterology VL - 91 IS - 1 N2 - A randomized, double-blind, placebo-controlled trial was conducted to determine the efficacy of a low-dose aluminum-magnesium antacid regimen (Link one tablet q.i.d.) (total neutralizing capacity 120 mmol HCl/day) in combination with a high- or a low-fiber diet in ulcer healing and relief of symptoms in patients with benign gastric ulcer. After 6 wk, the ulcer healed in 28 (67%) of the 42 patients treated with antacids compared with 11 (25%) of the 44 patients treated with placebo (p less than 0.001). Antacids were also significantly more effective than placebo in the relief of symptoms. The dietary treatment did not significantly influence ulcer healing or ulcer symptoms. Constipation was more frequently seen with the low- than with the high-fiber diet (p less than 0.01). No significant side effects from antacids were recorded. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/3011583/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/0016-5085(86)90438-5 DB - PRIME DP - Unbound Medicine ER -