Tags

Type your tag names separated by a space and hit enter

Associations between CT-determined visceral fat burden, hepatic steatosis, circulating white blood cell counts and neutrophil-to-lymphocyte ratio.
PLoS One. 2018; 13(11):e0207284.Plos

Abstract

Visceral adiposity is associated with cardiovascular disease, an association that may be mediated in part by inflammation. We hypothesized that regional measures of visceral adiposity would associate with commonly obtained clinical measures of immune status. We consecutively studied 3,291 subjects (mean age, 49.8±9.8 years) who underwent an annual cardiovascular risk survey. Peri-cardial (PCF) and thoracic peri-aortic adipose tissue (TAT) volumes were determined by dedicated computed tomography (CT) software (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA). Hepatic steatosis was assessed by abdominal ultrasonography. We explored cross-sectional associations between visceral fat measures and high-sensitivity C-reactive protein (hs-CRP), leukocyte counts, and the neutrophil-to-lymphocyte ration (NLR). Among 3,291 study participants, we observed positive linear associations between PCF and TAT, higher degree of hepatic steatosis and hs-CRP, various leukocyte counts, either total and its differential counts, and NLR (all trend p<0.001). Multi-variate linear and logistic regression models showed independent associations between PCF/TAT (β-Coef: 0.14/0.16, both p<0.05) and total WBC counts, with only TAT further demonstrated significant relations with neutrophil counts and NLR (both p<0.05) and independently identified abnormally high WBC and NLR (Odds ratio: 1.18 & 1.21, both p<0.05). C-statistics showed significant incremental model prediction for abnormally high WBC and NLR (both ΔAUROC<0.05) when TAT was superimposed on traditional cardiovascular risks and biochemical information. Greater visceral adiposity burden and hepatic steatosis may be associated with higher circulating leukocyte counts and markers for atherosclerosis, with more pronounced influences for peri-aortic adiposity. Our data suggested the differential biological impacts for region-specific visceral adiposity.

Links

PMC Free PDF

Authors+Show Affiliations

Sung KT
Department of Medicine, Mackay Medical College, Taipei, Taiwan. Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Kuo R
Department of Medicine, Mackay Medical College, Taipei, Taiwan. Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan.
Sun JY
Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan.
Hung TC
Department of Medicine, Mackay Medical College, Taipei, Taiwan. Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. Department of Medical Technology, Yuanpei University of Science and Technology, Hsin-Chu, Taiwan.
Chang SC
Department of Medicine, Mackay Medical College, Taipei, Taiwan. Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan.
Liu CC
Department of Medical Technology, Yuanpei University of Science and Technology, Hsin-Chu, Taiwan. Graduate Institute of Health Care Organization Administration, College of Public Health National Taiwan University, Taipei, Taiwan. Health Evaluation Center, Mackay Memorial Hospital, Taipei, Taiwan.
Yun CH
Department of Medicine, Mackay Medical College, Taipei, Taiwan. Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan.
Wu TH
Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan.
Hung CL
Department of Medicine, Mackay Medical College, Taipei, Taiwan. Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Yeh HI
Department of Medicine, Mackay Medical College, Taipei, Taiwan. Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Hou CJ
Department of Medicine, Mackay Medical College, Taipei, Taiwan. Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Cury RC
Cardiovascular MRI and CT Program, Baptist Cardiac Vascular Institute, Miami, Florida, United States of America.
Zidar DA
Division of Cardiology, Department of Internal Medicine, University Hospitals Harrington Heart & Vascular Institute, Case Western Reserve University, Cleveland, OH, United States of America.
Bezerra HG
Division of Cardiology, Department of Internal Medicine, University Hospitals Harrington Heart & Vascular Institute, Case Western Reserve University, Cleveland, OH, United States of America.
Longenecker CT
Division of Cardiology, Department of Internal Medicine, University Hospitals Harrington Heart & Vascular Institute, Case Western Reserve University, Cleveland, OH, United States of America.

MeSH

AdiposityAdultC-Reactive ProteinCardiovascular DiseasesFatty LiverFemaleHumansIntra-Abdominal FatLymphocyte CountLymphocytesMaleMiddle AgedNeutrophilsTomography, X-Ray Computed

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30458019

Citation

Sung, Kuo-Tzu, et al. "Associations Between CT-determined Visceral Fat Burden, Hepatic Steatosis, Circulating White Blood Cell Counts and Neutrophil-to-lymphocyte Ratio." PloS One, vol. 13, no. 11, 2018, pp. e0207284.
Sung KT, Kuo R, Sun JY, et al. Associations between CT-determined visceral fat burden, hepatic steatosis, circulating white blood cell counts and neutrophil-to-lymphocyte ratio. PLoS One. 2018;13(11):e0207284.
Sung, K. T., Kuo, R., Sun, J. Y., Hung, T. C., Chang, S. C., Liu, C. C., Yun, C. H., Wu, T. H., Hung, C. L., Yeh, H. I., Hou, C. J., Cury, R. C., Zidar, D. A., Bezerra, H. G., & Longenecker, C. T. (2018). Associations between CT-determined visceral fat burden, hepatic steatosis, circulating white blood cell counts and neutrophil-to-lymphocyte ratio. PloS One, 13(11), e0207284. https://doi.org/10.1371/journal.pone.0207284
Sung KT, et al. Associations Between CT-determined Visceral Fat Burden, Hepatic Steatosis, Circulating White Blood Cell Counts and Neutrophil-to-lymphocyte Ratio. PLoS One. 2018;13(11):e0207284. PubMed PMID: 30458019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between CT-determined visceral fat burden, hepatic steatosis, circulating white blood cell counts and neutrophil-to-lymphocyte ratio. AU - Sung,Kuo-Tzu, AU - Kuo,Richard, AU - Sun,Jing-Yi, AU - Hung,Ta-Chuan, AU - Chang,Shun-Chuan, AU - Liu,Chuan-Chuan, AU - Yun,Chun-Ho, AU - Wu,Tung-Hsin, AU - Hung,Chung-Lieh, AU - Yeh,Hung-I, AU - Hou,Charles Jia-Yin, AU - Cury,Ricardo C, AU - Zidar,David A, AU - Bezerra,Hiram G, AU - Longenecker,Chris T, Y1 - 2018/11/20/ PY - 2018/06/19/received PY - 2018/10/29/accepted PY - 2018/11/21/entrez PY - 2018/11/21/pubmed PY - 2019/4/17/medline SP - e0207284 EP - e0207284 JF - PloS one JO - PLoS One VL - 13 IS - 11 N2 - Visceral adiposity is associated with cardiovascular disease, an association that may be mediated in part by inflammation. We hypothesized that regional measures of visceral adiposity would associate with commonly obtained clinical measures of immune status. We consecutively studied 3,291 subjects (mean age, 49.8±9.8 years) who underwent an annual cardiovascular risk survey. Peri-cardial (PCF) and thoracic peri-aortic adipose tissue (TAT) volumes were determined by dedicated computed tomography (CT) software (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA). Hepatic steatosis was assessed by abdominal ultrasonography. We explored cross-sectional associations between visceral fat measures and high-sensitivity C-reactive protein (hs-CRP), leukocyte counts, and the neutrophil-to-lymphocyte ration (NLR). Among 3,291 study participants, we observed positive linear associations between PCF and TAT, higher degree of hepatic steatosis and hs-CRP, various leukocyte counts, either total and its differential counts, and NLR (all trend p<0.001). Multi-variate linear and logistic regression models showed independent associations between PCF/TAT (β-Coef: 0.14/0.16, both p<0.05) and total WBC counts, with only TAT further demonstrated significant relations with neutrophil counts and NLR (both p<0.05) and independently identified abnormally high WBC and NLR (Odds ratio: 1.18 & 1.21, both p<0.05). C-statistics showed significant incremental model prediction for abnormally high WBC and NLR (both ΔAUROC<0.05) when TAT was superimposed on traditional cardiovascular risks and biochemical information. Greater visceral adiposity burden and hepatic steatosis may be associated with higher circulating leukocyte counts and markers for atherosclerosis, with more pronounced influences for peri-aortic adiposity. Our data suggested the differential biological impacts for region-specific visceral adiposity. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/30458019/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓7 ↑47]

Related Citations

    More

    Others Viewed