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Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.
Eur J Nutr. 2019 Dec; 58(8):3135-3146.EJ

Abstract

PURPOSE

It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline.

METHODS

The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. One-hundred healthy men with serum TT levels < 10.4 nmol/l and 25-hydroxyvitamin D [25(OH)D] levels < 75 nmol/l participated in the trial. Subjects were randomized to receive 20,000 IU of vitamin D3/week (n = 50) or placebo (n = 50) for 12 weeks. Primary outcome was TT measured using mass spectrometry. Secondary outcomes were free testosterone, free androgen index, sex hormone-binding globulin, estradiol, follicle-stimulating hormone, luteinizing hormone, metabolic characteristics, and body composition.

RESULTS

Ninety-four men [mean age and 25(OH)D: 47 (± 12) years and 56.3 (± 18.3) nmol/l, respectively] completed the study. We found no significant treatment effect on serum TT or on the remaining secondary outcome variables.

CONCLUSION

Vitamin D treatment had no effect on serum TT levels in middle-aged healthy men with low TT levels.

Links

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Authors+Show Affiliations

Lerchbaum E
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Elisabeth.lerchbaum@medunigraz.at.
Trummer C
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Theiler-Schwetz V
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Kollmann M
Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria.
Wölfler M
Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria.
Heijboer AC
Endocrine Laboratory, Department of Clinical Chemistry, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. Laboratory of Endocrinology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Pilz S
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Obermayer-Pietsch B
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.

MeSH

AdultAndrogensAustriaDietary SupplementsDouble-Blind MethodHumansMaleMiddle AgedTestosteroneVitamin DVitamins

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30460609

Citation

Lerchbaum, Elisabeth, et al. "Effects of Vitamin D Supplementation On Androgens in Men With Low Testosterone Levels: a Randomized Controlled Trial." European Journal of Nutrition, vol. 58, no. 8, 2019, pp. 3135-3146.
Lerchbaum E, Trummer C, Theiler-Schwetz V, et al. Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial. Eur J Nutr. 2019;58(8):3135-3146.
Lerchbaum, E., Trummer, C., Theiler-Schwetz, V., Kollmann, M., Wölfler, M., Heijboer, A. C., Pilz, S., & Obermayer-Pietsch, B. (2019). Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial. European Journal of Nutrition, 58(8), 3135-3146. https://doi.org/10.1007/s00394-018-1858-z
Lerchbaum E, et al. Effects of Vitamin D Supplementation On Androgens in Men With Low Testosterone Levels: a Randomized Controlled Trial. Eur J Nutr. 2019;58(8):3135-3146. PubMed PMID: 30460609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial. AU - Lerchbaum,Elisabeth, AU - Trummer,Christian, AU - Theiler-Schwetz,Verena, AU - Kollmann,Martina, AU - Wölfler,Monika, AU - Heijboer,Annemieke C, AU - Pilz,Stefan, AU - Obermayer-Pietsch,Barbara, Y1 - 2018/11/20/ PY - 2018/8/7/received PY - 2018/11/4/accepted PY - 2018/11/22/pubmed PY - 2020/4/28/medline PY - 2018/11/22/entrez PY - 2018/11/20/pmc-release KW - Androgens KW - Randomized controlled trial KW - SHBG KW - Testosterone KW - Vitamin D SP - 3135 EP - 3146 JF - European journal of nutrition JO - Eur J Nutr VL - 58 IS - 8 N2 - PURPOSE: It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline. METHODS: The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. One-hundred healthy men with serum TT levels < 10.4 nmol/l and 25-hydroxyvitamin D [25(OH)D] levels < 75 nmol/l participated in the trial. Subjects were randomized to receive 20,000 IU of vitamin D3/week (n = 50) or placebo (n = 50) for 12 weeks. Primary outcome was TT measured using mass spectrometry. Secondary outcomes were free testosterone, free androgen index, sex hormone-binding globulin, estradiol, follicle-stimulating hormone, luteinizing hormone, metabolic characteristics, and body composition. RESULTS: Ninety-four men [mean age and 25(OH)D: 47 (± 12) years and 56.3 (± 18.3) nmol/l, respectively] completed the study. We found no significant treatment effect on serum TT or on the remaining secondary outcome variables. CONCLUSION: Vitamin D treatment had no effect on serum TT levels in middle-aged healthy men with low TT levels. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/30460609 DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓19 ↑29]

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